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First Record of Anguillid Herpesvirus 1 Linked to a Mass Mortality Event in Shortfin Eel (Anguilla bicolor) in Indonesia

Jurnal Medik Veteriner · Vol. 8 No. 1 (2025) · pp. 134–143

DOI
10.20473/jmv.vol8.iss1.2025.134-143
ISSN
2581-012X, 2615-7497
Published
2025-04-01
Publisher
Universitas Airlangga
Language
eng
License
creativecommons.org/licenses/by-nc-sa/4.0

Abstract

Anguillid herpesvirus 1 (AngHV-1), a member of the Alloherpesviridae family, is known to cause high mortality in both wild and farmed eels. Notably, no cases of AngHV-1 infection in Indonesia until June 2023, when a significant mortality rate exceeding 75% among cultured glass eels was documented in Bogor, Indonesia. This study investigated the outbreak by collecting 30 diseased fish from multiple cultured tanks to examine clinical symptoms, histopathological changes, and viral presence through PCR targeting the viral DNA polymerase gene. Hemorrhagic lesions in the abdomen and anal regions were the primary clinical symptoms. Histopathological examination revealed hyperplasia, fusion, and epithelial lifting of the gill secondary lamellae. PCR, using 394 bp primer specific for AngHV-1, confirmed 100% infection among the collected samples, indicating rapid viral transmission within the rearing environment. Phylogenetic analysis of partial DNA polymerase amino acid sequences showed that Indonesian AngHV-1 isolate is genetically diverse and shares similarities with strains from China, Taiwan, Canada, and several European countries, suggesting the emergence of a novel strain. This study highlights the urgent need for enhanced biosecurity measures to curb AngHV-1 spread in the Indonesian eel aquaculture sector.

Keywords

Collaboration network of the authors

40 authors · 217 co-authorship links · 35 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • National Research and Innovation Agency
  • IPB University
  • Sriwijaya University
  • Badan Pengkajian dan Penerapan Teknologi
  • Universitas Dayanu Ikhsanuddin
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Yohanes Pamungkas BawonoNational Research and Innovation Agency12
Muhamad Kholik FirmansyahNational Research and Innovation Agency12
AlimuddinAffiliation unknown2
Komar SumantadinataIPB University2
Agus Oman SudrajatIPB University2
Utut WidyastutiIPB University1
Mochamad SyaifudinSriwijaya University1
RUSTIDJAAffiliation unknown1
Irvan FaizalBadan Pengkajian dan Penerapan Teknologi1
Gemi TriastutikIPB University1
Slamet SubyaktoIPB University1
M. SASMITO JATIIPB University1
Irzal EffendiIPB University1
Suko IsmiNational Research and Innovation Agency1
Belinda AstariIPB University1
Yani HadiroseyaniIPB University1
Eddy SupriyonoIPB University1
Budiyanti BudiyantiUniversitas Dayanu Ikhsanuddin1
Ridwan AffandiAffiliation unknown1
Yanti SinagaAffiliation unknown1
Mala NurilmalaIPB University1
Agoes Mardiono JacoebIPB University1
Ronny Irawan WahjuIPB University1
Rizsa Mustika PertiwiIPB University1
Mohammad Mukhlis KamalIPB University1
Yanti SinagaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JMV/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">First Record of Anguillid Herpesvirus 1 Linked to a Mass Mortality Event in Shortfin Eel (Anguilla bicolor) in Indonesia</dc:title>
	<dc:creator>Romadhona, Ekky Ilham</dc:creator>
	<dc:creator>Widantara, Handang</dc:creator>
	<dc:creator>Aslia, Aslia</dc:creator>
	<dc:creator>Megawati, Novi</dc:creator>
	<dc:creator>Ardiansyah, Arif Rahmat</dc:creator>
	<dc:creator>Larassagita, Annisa Fitri</dc:creator>
	<dc:creator>Dewi, Kiki Mariya</dc:creator>
	<dc:creator>Farman, Aditia</dc:creator>
	<dc:creator>Chaidir, Iding</dc:creator>
	<dc:creator>Sujatmiko, Wisnu</dc:creator>
	<dc:creator>Yaniharto, Dedy</dc:creator>
	<dc:creator>Budiardi, Tatag</dc:creator>
	<dc:creator>Aliah, Ratu Siti</dc:creator>
	<dc:creator>Sutanti, Sutanti</dc:creator>
	<dc:subject xml:lang="en-US">Anguillid herpesvirus 1</dc:subject>
	<dc:subject xml:lang="en-US">Molecular detection</dc:subject>
	<dc:subject xml:lang="en-US">Indonesia</dc:subject>
	<dc:subject xml:lang="en-US">Phylogenetic</dc:subject>
	<dc:subject xml:lang="en-US">Histology</dc:subject>
	<dc:description xml:lang="en-US">Anguillid herpesvirus 1 (AngHV-1), a member of the Alloherpesviridae family, is known to cause high mortality in both wild and farmed eels. Notably, no cases of AngHV-1 infection in Indonesia until June 2023, when a significant mortality rate exceeding 75% among cultured glass eels was documented in Bogor, Indonesia. This study investigated the outbreak by collecting 30 diseased fish from multiple cultured tanks to examine clinical symptoms, histopathological changes, and viral presence through PCR targeting the viral DNA polymerase gene. Hemorrhagic lesions in the abdomen and anal regions were the primary clinical symptoms. Histopathological examination revealed hyperplasia, fusion, and epithelial lifting of the gill secondary lamellae. PCR, using 394 bp primer specific for AngHV-1, confirmed 100% infection among the collected samples, indicating rapid viral transmission within the rearing environment. Phylogenetic analysis of partial DNA polymerase amino acid sequences showed that Indonesian AngHV-1 isolate is genetically diverse and shares similarities with strains from China, Taiwan, Canada, and several European countries, suggesting the emergence of a novel strain. This study highlights the urgent need for enhanced biosecurity measures to curb AngHV-1 spread in the Indonesian eel aquaculture sector.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2025-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JMV/article/view/62191</dc:identifier>
	<dc:identifier>10.20473/jmv.vol8.iss1.2025.134-143</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Medik Veteriner; Vol. 8 No. 1 (2025): April; 134-143</dc:source>
	<dc:source>2581-012X</dc:source>
	<dc:source>2615-7497</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/62191/32231</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Ekky Ilham Romadhona, Handang Widantara, Aslia Aslia, Novi Megawati, Arif Rahmat Ardiansyah, Annisa Fitri Larassagita, Kiki Mariya Dewi, Aditia Farman, Iding Chaidir, Wisnu Sujatmiko, Dedy Yaniharto, Tatag Budiardi, Ratu Siti Aliah, Sutanti Sutanti</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
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