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Effect of Physical Exercise on Insulin Sensitivity and the Modifiable Cardiovascular Risk Factors of Patients with T2DM: A Systematic Review

Jurnal Ners · Vol. 15 No. 1Sp (2020) · pp. 518–530

DOI
10.20473/jn.v15i1Sp.20521
ISSN
2502-5791, 1858-3598
Published
2020-07-07
Publisher
Universitas Airlangga
Language
eng

Abstract

Introduction: This study was undertaken to verify effect of regular exercise training on insulin sensitivity and the modifiable cardiovascular risk factors, and to determine if there was any effect from the different regular exercises. Methods: A database search using PRISMA examined articles from Scopus, ScienceDirect and ProQuest. The inclusion criteria were that the article used a randomized controlled trial within the last 10 years, that the respondents were people with type 2 diabetes mellitus and that only physical exercise was the intervention involved. In total, 1,303 articles were screened and 16 articles were included that fit the criteria of inclusion in this systematic review. Results: Based on the review of the 15 articles, the findings show that regular exercise training has some benefits related to glycemic control. It can reduce insulin resistance, plasma insulin, fasting blood glucose, postpandrial blood glucose and hbA1c.. Moreover, physical exercise has other benefits for people with type 2 diabetes mellitus, such as an increased peak oxygen consumption (VO2 peak) and decreased c-reactive protein (CRP) level. Conclusion: Regular exercise training has benefits for people with type 2 diabetes mellitus and it can allow them to achieve of optimal glycemic control by improving insulin resistance and decreasing the cardiovascular risk factors. Physical exercise such as combined exercises (aerobic and resistance exercise) or a single exercise such as aerobic exercise can be recommended to improve insulin sensitivity and the modifiable cardiovascular risk factors in patients with T2DM.

Keywords

Collaboration network of the authors

40 authors · 128 co-authorship links · 1 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Airlangga
  • Universitas Kadiri
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Nursalam NursalamAffiliation unknown9
Tintin SukartiniAffiliation unknown5
Joni HaryantoUniversitas Airlangga4
Rifky Octavia PradiptaAffiliation unknown3
Esti YunitasariAffiliation unknown3
Anis FauziahAffiliation unknown2
Inta SusantiAffiliation unknown2
Setyoadi SetyoadiAffiliation unknown2
Ilya KrisnanaUniversitas Airlangga2
Devangga Darma KaringgaUniversitas Kadiri2
Angeline BushyAffiliation unknown2
Erna Dwi WahyuniAffiliation unknown2
Eka Putri AditamaUniversitas Airlangga1
Lingga Curnia DewiUniversitas Airlangga1
Vira AmeliaAffiliation unknown1
Trihaningsih Puji AstutiAffiliation unknown1
Pipit FerianiAffiliation unknown1
Rini ErnawatiAffiliation unknown1
Reny Mareta SariAffiliation unknown1
Niken Agus TianingrumAffiliation unknown1
Nurus SafaahAffiliation unknown1
Wahyu Agustin Eka LestariAffiliation unknown1
Neisya Pratiwindya SudarsiwiAffiliation unknown1
Nurul Hikmatul QowiAffiliation unknown1
Tri Johan Agus YuswantoAffiliation unknown1
Novianti LailiahAffiliation unknown1
Made Mahaguna PutraAffiliation unknown1
Sismulyanto SismulyantoAffiliation unknown1
Aditha Angga PratamaAffiliation unknown1
I Made Moh. Yanuar SaifudinAffiliation unknown1
Rika SarfikaAffiliation unknown1
Fitri MailaniAffiliation unknown1
Putri Indah PermataAffiliation unknown1
Nindy Eka WijayaAffiliation unknown1
Andi Safutra SurayaAffiliation unknown1
Nununk Dwi Nur KhairunnissaAffiliation unknown1
Yong Shian GohAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://e-journal.unair.ac.id/index.php/JNERS/oai, first harvested 9 Nov 2026, last seen 9 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Effect of Physical Exercise on Insulin Sensitivity and the Modifiable Cardiovascular Risk Factors of Patients with T2DM: A Systematic Review</dc:title>
	<dc:creator>Sukma Samudera, Wahyu</dc:creator>
	<dc:creator>Efendi, Ferry</dc:creator>
	<dc:creator>Indarwati, Retno</dc:creator>
	<dc:subject xml:lang="en-US">regular physical training</dc:subject>
	<dc:subject xml:lang="en-US">insulin resistance</dc:subject>
	<dc:subject xml:lang="en-US">cardiovascular risk factors</dc:subject>
	<dc:subject xml:lang="en-US">type 2 diabetes mellitus.</dc:subject>
	<dc:description xml:lang="en-US">Introduction:  This study was undertaken to verify effect of regular exercise training on insulin sensitivity and the modifiable cardiovascular risk factors, and to determine if there was any effect from the different regular exercises. Methods: A database search using PRISMA examined articles from Scopus, ScienceDirect and ProQuest. The inclusion criteria were that the article used a randomized controlled trial within the last 10 years, that the respondents were people with type 2 diabetes mellitus and that only physical exercise was the intervention involved. In total, 1,303 articles were screened and 16 articles were included that fit the criteria of inclusion in this systematic review. Results: Based on the review of the 15 articles, the findings show that regular exercise training has some benefits related to glycemic control. It can reduce insulin resistance, plasma insulin, fasting blood glucose, postpandrial blood glucose and hbA1c. . Moreover, physical exercise has other benefits for people with type 2 diabetes mellitus, such as an increased peak oxygen consumption (VO2 peak) and decreased c-reactive protein (CRP) level. Conclusion: Regular exercise training has benefits for people with type 2 diabetes mellitus and it can allow them to achieve of optimal glycemic control by improving insulin resistance and decreasing the cardiovascular risk factors. Physical exercise such as combined exercises (aerobic and resistance exercise) or a single exercise such as aerobic exercise can be recommended to improve insulin sensitivity and the modifiable cardiovascular risk factors in patients with T2DM.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2020-07-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JNERS/article/view/20521</dc:identifier>
	<dc:identifier>10.20473/jn.v15i1Sp.20521</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Ners; Vol. 15 No. 1Sp (2020): Special Issue; 518-530</dc:source>
	<dc:source>2502-5791</dc:source>
	<dc:source>1858-3598</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JNERS/article/view/20521/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Jurnal Ners</dc:rights>
</oai_dc:dc>