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The Combination Diagnostic Test for Tuberculosis Screening in HIV Patients in Referral Hospitals in Indonesia

Public Health of Indonesia · Vol. 11 No. 3 (2025) · pp. 172–180

DOI
10.36685/phi.v11i3.1094
ISSN
2477-1570, 2528-1542
Published
2025-08-30
Publisher
YCAB Publisher
Language
eng
License
creativecommons.org/licenses/by-nc/4.0

Abstract

Background: Screening tests are needed to help screen suspected Tuberculosis (TB) pulmonary with HIV positive. With the limitation of specificity of the screening test and the need for combination with laboratory tools to increase that, a combination with standard examination is still needed, especially for limited healthcare facilities. Objective: This study aimed to determine Pulmonary TB screening tests with Human Immunodeficiency Syndrome (HIV) positive. Method: This observational study with a cross-sectional design was conducted in four government hospitals. Study subjects were inpatients and outpatients who met study inclusion criteria (> 14 years of age, HIV positive based on HIV test results, had clinical symptoms of episodic history of fever, and volunteered to take part in the study). Total subjects were 193 people, with episodic history of fever from 85%. Still, only the complete combination has a specificity of> 70%. The combination of “Night Sweat + Enlargement of Lymph Nodes + Left Rhonchi + Infiltrates in the Upper Lobe” and then “Enlargement of Lymph Nodes + Left Rhonchi + Infiltrates in the Upper Lobe” can be an alternative for screening Pulmonary TB-HIV positive with history of fever. Conclusion: Pulmonary TB screening in HIV patients with a history of fever can be used by completely combining clinical manifestation, physical examination, and X-ray. the variables "Night Sweat, Enlarged Lymph Nodes, left rhonchi breath sounds and pulmonary upper lobe infiltrates" in a gradual manner. Keywords: Diagnostic Combination Test; HIV-Tb Coinfection; Tuberculosis Screening; Clinical Manifestations in TB-HIV; Pulmonary TB in HIV Patients

Keywords

Collaboration network of the authors

40 authors · 222 co-authorship links · showing the 40 most connected

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Co-authorOrganisationJoint articles
Instiaty InstiatyAffiliation unknown2
Purwantyastuti AscobatAffiliation unknown2
Angelina SianeAffiliation unknown1
William WilliamAffiliation unknown1
Erlina BurhanAffiliation unknown1
Rita RogayahAffiliation unknown1
Agus Dwi SusantoAffiliation unknown1
Ibrahim Nur Insan Putra DharmawanAffiliation unknown1
Markus MeyerAffiliation unknown1
ROBIATUL ADAWIYAHAffiliation unknown1
Rudyanto SedonoAffiliation unknown1
Erni Juwita NelwanAffiliation unknown1
Mulya Rahma KaryantiAffiliation unknown1
Anna RozaliyaniAffiliation unknown1
Findra SetianingrumAffiliation unknown1
Yulia Rosa SaharmanAffiliation unknown1
Dita AditianingsihAffiliation unknown1
Adityo SusiloAffiliation unknown1
Mardiastuti WahidAffiliation unknown1
Siti PratiekauriAffiliation unknown1
Fathiyah IsbaniahAffiliation unknown1
Vera IrawanyAffiliation unknown1
Debbie LatupeirissaAffiliation unknown1
Nina Dwi PutriAffiliation unknown1
Winda SofvinaAffiliation unknown1
Mulyati TugiranAffiliation unknown1
Sultana MH FaradzAffiliation unknown1
Muhammad Hussein GasemAffiliation unknown1
Adang BachtiarAffiliation unknown1
Jaslis IlyasAffiliation unknown1
Harimat HendrawanAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://stikbar.org/ycabpublisher/index.php/PHI/oai, first harvested 10 Nov 2026, last seen 10 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Combination Diagnostic Test for Tuberculosis Screening in HIV Patients in Referral Hospitals in Indonesia</dc:title>
	<dc:creator>Murtiani, Farida</dc:creator>
	<dc:creator>Rosamarlina, Rosamarlina</dc:creator>
	<dc:creator>Purnama, Asep </dc:creator>
	<dc:creator>Farhanah, Nur </dc:creator>
	<dc:creator> Utama, Made Susila</dc:creator>
	<dc:creator> Agustin, Heidy</dc:creator>
	<dc:creator>Sarif, Armaji Kamaludi </dc:creator>
	<dc:creator>Widiantari, Aninda Dinar</dc:creator>
	<dc:creator>Hasugian, Armedy Ronny</dc:creator>
	<dc:subject xml:lang="en-US">Diagnostic</dc:subject>
	<dc:subject xml:lang="en-US">HIV</dc:subject>
	<dc:subject xml:lang="en-US">Screening</dc:subject>
	<dc:subject xml:lang="en-US">Tuberculosis</dc:subject>
	<dc:description xml:lang="en-US">Background: Screening tests are needed to help screen suspected Tuberculosis (TB) pulmonary with HIV positive. With the limitation of specificity of the screening test and the need for combination with laboratory tools to increase that, a combination with standard examination is still needed, especially for limited healthcare facilities.
Objective: This study aimed to determine Pulmonary TB screening tests with Human Immunodeficiency Syndrome (HIV) positive.
Method: This observational study with a cross-sectional design was conducted in four government hospitals. Study subjects were inpatients and outpatients who met study inclusion criteria (&amp;gt; 14 years of age, HIV positive based on HIV test results, had clinical symptoms of episodic history of fever, and volunteered to take part in the study). Total subjects were 193 people, with episodic history of fever from &amp;lt;24 hours to 120 hours.
Result: This study assessed a subject's clinical manifestation, physical examination and X-ray test. The “Night Sweat”, Infiltrates in the Upper Lobe”, “Enlargement of Lymph Nodes and “Left Rhonchi” and their combination have a sensitivity of&amp;gt;85%. Still, only the complete combination has a specificity of&amp;gt; 70%. The combination of “Night Sweat + Enlargement of Lymph Nodes + Left Rhonchi + Infiltrates in the Upper Lobe” and then “Enlargement of Lymph Nodes + Left Rhonchi + Infiltrates in the Upper Lobe” can be an alternative for screening Pulmonary TB-HIV positive with history of fever.
Conclusion: Pulmonary TB screening in HIV patients with a history of fever can be used by completely combining clinical manifestation, physical examination, and X-ray. the variables "Night Sweat, Enlarged Lymph Nodes, left rhonchi breath sounds and pulmonary upper lobe infiltrates" in a gradual manner.
Keywords: Diagnostic Combination Test; HIV-Tb Coinfection; Tuberculosis Screening; Clinical Manifestations in TB-HIV; Pulmonary TB in HIV Patients</dc:description>
	<dc:publisher xml:lang="en-US">YCAB Publisher</dc:publisher>
	<dc:date>2025-08-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://stikbar.org/ycabpublisher/index.php/PHI/article/view/1094</dc:identifier>
	<dc:identifier>10.36685/phi.v11i3.1094</dc:identifier>
	<dc:source xml:lang="en-US">Public Health of Indonesia; Vol. 11 No. 3 (2025): July - September; 172 - 180</dc:source>
	<dc:source>2477-1570</dc:source>
	<dc:source>2528-1542</dc:source>
	<dc:source>10.36685/phi.v11i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://stikbar.org/ycabpublisher/index.php/PHI/article/view/1094/603</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Farida Murtiani, Rosamarlina Rosamarlina, Asep  Purnama, Nur  Farhanah, Made Susila  Utama, Heidy  Agustin, Armaji Kamaludi  Sarif, Aninda Dinar Widiantari, Armedy Ronny Hasugian</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>