Melola Discovery

← Melola Discovery

Journal SINTA 1

Antihyperlipidemic Activity of Ethanol Extract Mindi’s Leaves (Melia azedarach Linn.) in Male Wistar Rats Induced Propiltiouracil

Science and Technology Indonesia · Vol. 4 No. 1 (2019) · pp. 24–30

DOI
10.26554/sti.2019.4.1.24-30
ISSN
2580-4391, 2580-4405
Published
2019-01-27
Publisher
Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya
Language
eng

Abstract

Mindi’s leaves (Melia azedarach Linn.) is an Indonesian medicinal plant that used as traditional medicine. Mindi leaves contains some secondary metabolites which have potency to decreased total cholesterol and LDL level. The study purposed to know antihyperlipidemic effect of ethanol extract of mindi’s leaves (Melia azedarach Linn.) seen from total cholesterol, and LDL in male albino rats. Male wistar albino rats were divided into 5 groups, negative control group (sodium CMC 0.5%), positive control group (simvastatin 0.193 mg/200 gBW), group I (ethanol extract mindi’s leaves with dosage 300 mg/200 gBW), group II (ethanol extract mindi’s leaves with dosage 600 mg/200 gBW), and group III (ethanol extract mindi’s leaves with dosage 1200 mg/200 gBW). The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract was given for the next 15 days. Average cholesterol level, LDL, and body weight after induction was 90.28 mg/dL, 31.09 mg/dL, and 222.32 g. The result showed ethanol extract mindi’s leaves could decreased total cholesterol level and LDL level with % decreased in total cholesterol (%PDTC) and % decreased in LDL (%PDLDL) of group I is 37.78% and 35.57%, group II is 45.99% and 40.39%, and for group III is 56.29% and 52.42%. The result showed that ethanol extract of mindi’s leaves has antihyperlipidemic activity and significantly different from negative control (p>0.05). Based on the percentage relation of decreased total cholesterol and LDL levels to dose, then the effective dose 50 (ED50) value of ethanol extract mindi’s leave is 869 mg/200 gBW for total cholesterol and for LDL reduction level is 1086.84 mg/200 gBW

Keywords

Collaboration network of the authors

40 authors · 91 co-authorship links · 7 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Halu Oleo
  • Universitas Serambi Mekkah
  • State University of Makassar
  • Sebelas Maret University
  • University of Technology Malaysia
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Dian AswitaAffiliation unknown2
Evi AprianaAffiliation unknown2
Surahman SurahmanAffiliation unknown2
La Ode NafiuUniversitas Halu Oleo1
Muhammad Amrullah PagalaUniversitas Halu Oleo1
Fery Indradewi ArmadanyUniversitas Halu Oleo1
Sri WahyuniUniversitas Halu Oleo1
Juhaepa JuhaepaUniversitas Halu Oleo1
Ratna SupiyahUniversitas Halu Oleo1
Surdin SurdinUniversitas Halu Oleo1
Dian AswitaUniversitas Serambi Mekkah1
Ikramullah ZeinUniversitas Serambi Mekkah1
Abubakar AbubakarAffiliation unknown1
Muhammad AzzarkasyiAffiliation unknown1
Sri IsnowatiAffiliation unknown1
Maison MaisonAffiliation unknown1
Aprizal LukmanAffiliation unknown1
Sitti Rahma YunusState University of Makassar1
Rizal RizalUniversitas Halu Oleo1
MOHD FAIZ MOHD YAAKOBAffiliation unknown1
Yuliantini - YuliantiniSebelas Maret University1
Andriyanto AndriyantoAffiliation unknown1
Huber Yaspin TandiAffiliation unknown1
Lumuan LumuanAffiliation unknown1
Marites Del Prado AntonioAffiliation unknown1
Yusuf YusufUniversitas Halu Oleo1
Amran RasliUniversity of Technology Malaysia1
Arif FirmansyahAffiliation unknown1
Raveenthiran VivekanantharasaAffiliation unknown1
Ayu Cahyani AmiruddinAffiliation unknown1
Muyasaroh MuyasarohAffiliation unknown1
Bakhrum BakhrumAffiliation unknown1
Zaimuddin ZaimuddinAffiliation unknown1
Husaini HusainiAffiliation unknown1
Sri IsmawatiAffiliation unknown1
Safaruddin HarefaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://sciencetechindonesia.com/index.php/jsti/oai, first harvested 10 Nov 2026, last seen 10 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Antihyperlipidemic Activity of Ethanol Extract Mindi’s Leaves  (Melia azedarach Linn.) in Male Wistar Rats Induced Propiltiouracil</dc:title>
	<dc:creator>Herlina, Herlina</dc:creator>
	<dc:creator>Untari, Budi</dc:creator>
	<dc:creator>Solihah, Indah</dc:creator>
	<dc:creator>Santia, Merie</dc:creator>
	<dc:subject xml:lang="en-US">Melia azedarach Linn., antihyperlipidemia, total cholesterol, low density lipoprotein (LDL)</dc:subject>
	<dc:description xml:lang="en-US">Mindi’s leaves (Melia azedarach Linn.) is an Indonesian medicinal plant that used as traditional medicine. Mindi leaves contains some secondary metabolites which have potency to decreased total cholesterol and LDL level. The study purposed to know antihyperlipidemic effect of ethanol extract of mindi’s leaves (Melia azedarach Linn.) seen from total cholesterol, and LDL in male albino rats. Male wistar albino rats were divided into 5 groups, negative control group (sodium CMC 0.5%), positive control group (simvastatin 0.193 mg/200 gBW), group I (ethanol extract mindi’s leaves with dosage 300 mg/200 gBW), group II (ethanol extract mindi’s leaves with dosage 600 mg/200 gBW), and group III (ethanol extract mindi’s leaves with dosage 1200 mg/200 gBW). The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract was given for the next 15 days. Average cholesterol level, LDL, and body weight after induction was 90.28 mg/dL, 31.09 mg/dL, and 222.32 g. The result showed ethanol extract mindi’s leaves could decreased total cholesterol level and LDL level with % decreased in total cholesterol (%PDTC) and % decreased in LDL (%PDLDL) of group I is 37.78% and 35.57%, group II is 45.99% and 40.39%, and for group III is 56.29% and 52.42%. The result showed that ethanol extract of mindi’s leaves has antihyperlipidemic activity and significantly different from negative control (p&amp;gt;0.05). Based on the percentage relation of decreased total cholesterol and LDL levels to dose, then the effective dose 50 (ED50) value of ethanol extract mindi’s leave is 869 mg/200 gBW for total cholesterol and for LDL reduction level is 1086.84 mg/200 gBW</dc:description>
	<dc:publisher xml:lang="en-US">Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya</dc:publisher>
	<dc:date>2019-01-27</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://sciencetechindonesia.com/index.php/jsti/article/view/156</dc:identifier>
	<dc:identifier>10.26554/sti.2019.4.1.24-30</dc:identifier>
	<dc:source xml:lang="en-US">Science and Technology Indonesia; Vol. 4 No. 1 (2019): January; 24-30</dc:source>
	<dc:source>2580-4391</dc:source>
	<dc:source>2580-4405</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://sciencetechindonesia.com/index.php/jsti/article/view/156/100</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Herlina Herlina, Budi Untari, Indah Solihah, Merie Santia</dc:rights>
</oai_dc:dc>