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The Association of IGFBP7 Gene Polymorphism on Lamb Meat Quality in Javanese Thin-Tailed Sheep

Tropical Animal Science Journal · Vol. 47 No. 4 (2024) · pp. 448–455

DOI
10.5398/tasj.2024.47.4.448
ISSN
2615-790X, 2615-787X
Published
2024-12-09
Publisher
Faculty of Animal Science, IPB University
Language
eng

Abstract

The insulin-like growth factor binding-protein 7 (IGFBP7) gene is one of the potential genes related to meat quality. The objective of the current study was to evaluate polymorphism of the IGFBP7 gene (g.72351183A>C) and its association with meat quality traits in the Javanese thin-tailed (JTT) sheep. A comprehensive analysis was conducted on 88 JTT male sheep to examine their fatty acid composition, carcass characteristics, carcass retail cuts, and the physical properties of lamb meat. The polymorphism was detected using the PCR-RFLP technique. The association between the IGFBP7 gene polymorphism and the observed variables of meat quality was evaluated using one-way analysis of variance (ANOVA). The study results indicated that the IGFBP7 gene was polymorphic in JTT sheep population, with the allele distribution conforming to Hardy-Weinberg equilibrium. The AA genotype was found to be predominant. The IGFBP7 gene variants were associated (p<0.05) with erucic acid, linoleic acid, eicosapentaenoic acid, and total polyunsaturated fatty acid (PUFA). Sheep possesing the CC genotype exhibited the highest levels of linoleic acid, eicosapentaenoic acid, and total PUFA in comparison to those with AA and AC genotypes. However, the IGFBP7 gene polymorphism was not associated with carcass characteristics, carcass retail cuts, and physical properties of meat. These findings suggest that the IGFBP7 gene is a promising candidate marker for improving fatty acid composition in JTT sheep.

Keywords

Collaboration network of the authors

40 authors · 137 co-authorship links · showing the 40 most connected

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  • IPB University
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Geraldi NovianAffiliation unknown11
S. MurtiniAffiliation unknown11
Mochamad Yamin SaputraAffiliation unknown10
R.R. NoorAffiliation unknown8
Jakaria JakariaIPB University8
N. UlupiAffiliation unknown7
A AnggraeniAffiliation unknown6
I InounuAffiliation unknown5
D. LestariAffiliation unknown5
A FarajallahAffiliation unknown4
I. I. AriefAffiliation unknown4
M YaminAffiliation unknown4
R.I ArifiantiniAffiliation unknown4
Mona Fiametta FebriantyAffiliation unknown3
I SupriatnaAffiliation unknown3
F SaputraAffiliation unknown3
. JakariaAffiliation unknown3
R.H. MulyonoAffiliation unknown3
T SartikaAffiliation unknown3
D D SolihinAffiliation unknown3
M. RusdinAffiliation unknown3
M. F. UlumAffiliation unknown3
I KhaerunnisaAffiliation unknown3
Alen RismayadiAffiliation unknown2
Mustika FitriAffiliation unknown2
E AndreasAffiliation unknown2
L. PraharaniAffiliation unknown2
SubandriyoAffiliation unknown2
Eko HandiwirawanAffiliation unknown2
E.D GunardiAffiliation unknown2
A.B.L. IshakAffiliation unknown2
Anneke AnggraeniAffiliation unknown2
Cece SumantriIPB University2
L. HendraningsihAffiliation unknown1
J. AhmadiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.ipb.ac.id/index.php/tasj/oai, first harvested 10 Nov 2026, last seen 10 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">The Association of IGFBP7 Gene Polymorphism on Lamb Meat Quality in Javanese Thin-Tailed Sheep</dc:title>
	<dc:creator xml:lang="en">Komarudin</dc:creator>
	<dc:creator xml:lang="en">Listyarini, K.</dc:creator>
	<dc:creator xml:lang="en">Budiman, C.</dc:creator>
	<dc:creator xml:lang="en">Sumantri, C.</dc:creator>
	<dc:creator xml:lang="en">Gunawan, A.</dc:creator>
	<dc:subject xml:lang="en">IGFBP7 gene</dc:subject>
	<dc:subject xml:lang="en">Javanese thin-tailed sheep</dc:subject>
	<dc:subject xml:lang="en">lamb meat quality</dc:subject>
	<dc:description xml:lang="en">The insulin-like growth factor binding-protein 7 (IGFBP7) gene is one of the potential genes related to meat quality. The objective of the current study was to evaluate polymorphism of the IGFBP7 gene (g.72351183A&amp;gt;C) and its association with meat quality traits in the Javanese thin-tailed (JTT) sheep. A comprehensive analysis was conducted on 88 JTT male sheep to examine their fatty acid composition, carcass characteristics, carcass retail cuts, and the physical properties of lamb meat. The polymorphism was detected using the PCR-RFLP technique. The association between the IGFBP7 gene polymorphism and the observed variables of meat quality was evaluated using one-way analysis of variance (ANOVA). The study results indicated that the IGFBP7 gene was polymorphic in JTT sheep population, with the allele distribution conforming to Hardy-Weinberg equilibrium. The AA genotype was found to be predominant. The IGFBP7 gene variants were associated (p&amp;lt;0.05) with erucic acid, linoleic acid, eicosapentaenoic acid, and total polyunsaturated fatty acid (PUFA). Sheep possesing the CC genotype exhibited the highest levels of linoleic acid, eicosapentaenoic acid, and total PUFA in comparison to those with AA and AC genotypes. However, the IGFBP7 gene polymorphism was not associated with carcass characteristics, carcass retail cuts, and physical properties of meat. These findings suggest that the IGFBP7 gene is a promising candidate marker for improving fatty acid composition in JTT sheep.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Animal Science, IPB University</dc:publisher>
	<dc:date>2024-12-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ipb.ac.id/tasj/article/view/57574</dc:identifier>
	<dc:identifier>10.5398/tasj.2024.47.4.448</dc:identifier>
	<dc:source xml:lang="en">Tropical Animal Science Journal; Vol. 47 No. 4 (2024): Tropical Animal Science Journal; 448-455</dc:source>
	<dc:source>2615-790X</dc:source>
	<dc:source>2615-787X</dc:source>
	<dc:source>10.5398/tasj.2024.47.4</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ipb.ac.id/tasj/article/view/57574/29560</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Tropical Animal Science Journal</dc:rights>
</oai_dc:dc>