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Comparison of matrix metalloproteinase-9 and E-cadherin expression in early- and late-onset preeclampsia

Universa Medicina · Vol. 40 No. 3 (2021) · pp. 200–206

DOI
10.18051/UnivMed.2021.v40.200-206
ISSN
2407-2230, 1907-3062
Published
2021-09-23
Publisher
Faculty of Medicine, Universitas Trisakti
Language
eng
License
creativecommons.org/licenses/by-nc-sa/4.0

Abstract

BACKGROUNDPreeclampsia (PE) is one of the most common pregnancy complications worldwide. Turnover of villous trophoblast is affected by impaired placental perfusion in preeclampsia. Among the various factors that influence pro and antiangiogenic factors in trophoblast invasion of PE are E-cadherin and matrix metalloproteinase-9 (MMP-9). The current classification scheme differentiates PE into two variants early-onset (EO) and late-onset (LO) PE. The aim of this study was to compare MMP-9 and E-cadherin expression between early- (EO) and late-onset (LO) PE. METHODSThis study used a cross-sectional design involving 26 women with gestational age <34 weeks (EO) and 38 women with gestational age ≥34 weeks (LO) from PE patients. Placentas born to preeclamptic mothers were taken in the form of small pieces of the maternal side to measure the levels of MMP-9 and E-cadherin by the ELISA method. Statistical analysis was assessed using the Mann Whitney and independent t-test with a significant p value <0.05. RESULTSSemiquantitative proteinuria levels were significantly higher in EO-PE group compared to LO-PE group (p=0.000). Mean E-cadherin levels were significant lower in the EO-PE group (125.94 ± 54.22 pg/mg) compared to LO-PE group (157.95 ± 54.12 pg/mg) (p=0.024). However, there was no significance difference in median MMP-9 levels between EO-PE group and LO-PE group (p=0.376). CONCLUSIONThis study demonstrate that E-cadherin had lower levels in preeclampsia patients who gave birth <34 weeks. This study indicated that lower levels of e-cadherin can lead to early delivery in preeclampsia patients.

Keywords

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40 authors · 139 co-authorship links

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Co-authorOrganisationJoint articles
Kuntjoro HarimurtiAffiliation unknown2
Sri WuryantiAffiliation unknown1
Susworo SusworoAffiliation unknown1
Fiastuti WitjaksonoAffiliation unknown1
Dyah PurnamasariAffiliation unknown1
Siti SetiatiAffiliation unknown1
Tirza Z TaminAffiliation unknown1
Alida R HarahapAffiliation unknown1
Noto DwimartutieAffiliation unknown1
I Dewa Putu PramantaraAffiliation unknown1
Syahidatul WafaAffiliation unknown1
Evy YunihastutiAffiliation unknown1
Dante Saksono HarbuwonoAffiliation unknown1
Cleopas Martin RumendeAffiliation unknown1
Dicky Levenus TahaparyAffiliation unknown1
Farid KurniawanAffiliation unknown1
Ketut SuastikaAffiliation unknown1
Rona KartikaAffiliation unknown1
Tika PradnjaparamitaAffiliation unknown1
Reni ParamitaAffiliation unknown1
Hastuti Handayani S PurbaAffiliation unknown1
Febriana Catur IswantiAffiliation unknown1
Wawan MulyawanAffiliation unknown1
Abdul Halim SadikinAffiliation unknown1
Sri Widia Azraki JusmanAffiliation unknown1
April Hari WardhanaAffiliation unknown1
Dyah Haryuningtyas SawitriAffiliation unknown1
Nursalam NursalamAffiliation unknown1
Ririn ProbowatiAffiliation unknown1
Septi Fitrah NingtyasAffiliation unknown1
Mamik RatnawatiAffiliation unknown1
Afi yantiAffiliation unknown1
Gayatri GayatriAffiliation unknown1
Taniawati SupaliAffiliation unknown1
Suriyani TanAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, first harvested 10 Nov 2026, last seen 10 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Comparison of matrix metalloproteinase-9 and E-cadherin expression in early- and late-onset preeclampsia</dc:title>
	<dc:creator xml:lang="en">Samara, Tjam Diana </dc:creator>
	<dc:creator xml:lang="en">Wibowo, Heri </dc:creator>
	<dc:creator xml:lang="en">Liem, Isabella Kurnia </dc:creator>
	<dc:creator xml:lang="en">Prijanti, Ani Retno </dc:creator>
	<dc:creator xml:lang="en">Andrijono, Andrijono</dc:creator>
	<dc:subject xml:lang="en">MMP-9</dc:subject>
	<dc:subject xml:lang="en">E-cadherin</dc:subject>
	<dc:subject xml:lang="en">early-onset preeclampsia</dc:subject>
	<dc:subject xml:lang="en">late-onset preeclampsia</dc:subject>
	<dc:description xml:lang="en">BACKGROUNDPreeclampsia (PE) is one of the most common pregnancy complications worldwide. Turnover of villous trophoblast is affected by impaired placental perfusion in preeclampsia. Among the various factors that influence pro and antiangiogenic factors in trophoblast invasion of PE are E-cadherin and matrix metalloproteinase-9 (MMP-9). The current classification scheme differentiates PE into two variants early-onset (EO) and late-onset (LO) PE. The aim of this study was to compare MMP-9 and E-cadherin expression between early- (EO) and late-onset (LO) PE.
METHODSThis study used a cross-sectional design involving 26 women with gestational age &amp;lt;34 weeks (EO) and 38 women with gestational age ≥34 weeks (LO) from PE patients. Placentas born to preeclamptic mothers were taken in the form of small pieces of the maternal side to measure the levels of MMP-9 and E-cadherin by the ELISA method. Statistical analysis was assessed using the Mann Whitney and independent t-test with a significant p value &amp;lt;0.05.
RESULTSSemiquantitative proteinuria levels were significantly higher in EO-PE group compared to LO-PE group (p=0.000). Mean E-cadherin levels were significant lower in the EO-PE group (125.94 ± 54.22 pg/mg) compared to LO-PE group (157.95 ± 54.12 pg/mg) (p=0.024). However, there was no significance difference in median MMP-9 levels between EO-PE group and LO-PE group (p=0.376).
CONCLUSIONThis study demonstrate that E-cadherin had lower levels in preeclampsia patients who gave birth &amp;lt;34 weeks. This study indicated that lower levels of e-cadherin can lead to early delivery in preeclampsia patients.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2021-09-23</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/1181</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2021.v40.200-206</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 40 No. 3 (2021); 200-206</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:source>10.18051/UnivMed.2021.v40.i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/1181/678</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Tjam Diana  Samara, Heri  Wibowo, Isabella Kurnia  Liem, Ani Retno  Prijanti, Andrijono Andrijono</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>