Melola Discovery

← Melola Discovery

Journal SINTA 1

Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines

VALENSI · Vol. ume No. 2 (2020) · pp. 133–139

DOI
10.15408/jkv.v6i2.15976
ISSN
2548-3013, 2460-6065
Published
2020-12-01
Publisher
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Language
eng

Abstract

Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.

Keywords

Collaboration network of the authors

40 authors · 271 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • University of Malaya
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Nurlelasari NurlelasariAffiliation unknown39
Kindi FarabiAffiliation unknown37
Desi HarnetiAffiliation unknown37
Rani MaharaniAffiliation unknown31
Al Arofatus NainiAffiliation unknown29
Ace Tatang HidayatAffiliation unknown21
Darwati DarwatiAffiliation unknown15
Mohamad Nurul AzmiAffiliation unknown15
Erina HilmayantiAffiliation unknown12
Tati HerlinaAffiliation unknown7
Ricson Pemimpin HutagaolAffiliation unknown7
Harizon HarizonAffiliation unknown7
Wahyu SafriansyahAffiliation unknown6
Hadi KuncoroAffiliation unknown6
Khalijah AwangUniversity of Malaya6
Risyandi AnwarAffiliation unknown6
Sandra Amalia RiyadiAffiliation unknown6
Euis JulaehaAffiliation unknown5
Tjandrawati MozefAffiliation unknown5
Gian PrimahanaAffiliation unknown5
Dudi RunadiAffiliation unknown5
Purnama PurnamaAffiliation unknown5
Akhmad DarmawanAffiliation unknown5
Fajar Fauzi AbdullahAffiliation unknown4
Ronny LesmanaAffiliation unknown4
Agus SafariAffiliation unknown4
Muhammad HanafiAffiliation unknown4
Laode RijaiAffiliation unknown3
Susianti SusiantiAffiliation unknown2
Raihan Fathurrahman HasbillaAffiliation unknown2
Marissa AngelinaAffiliation unknown2
Sofna Dewita Sari BanjarnahorAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, first harvested 10 Nov 2026, last seen 10 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines</dc:title>
	<dc:creator xml:lang="en">Mayanti, Tri</dc:creator>
	<dc:creator xml:lang="en">Amir, Nur Insani</dc:creator>
	<dc:creator xml:lang="en">Katja, Dewa Gede</dc:creator>
	<dc:creator xml:lang="en">Fajriah, Sofa</dc:creator>
	<dc:creator xml:lang="en">Darmawan, Ahmad</dc:creator>
	<dc:creator xml:lang="en">Supratman, Unang</dc:creator>
	<dc:creator xml:lang="en">Awang, Khlaijah</dc:creator>
	<dc:creator xml:lang="en">Shiono, Yoshihito</dc:creator>
	<dc:subject xml:lang="en">cytotoxic activity</dc:subject>
	<dc:subject xml:lang="en">Dysoxylum nutans</dc:subject>
	<dc:subject xml:lang="en">MCF-7 breast cancer cells</dc:subject>
	<dc:subject xml:lang="en">Meliaceae</dc:subject>
	<dc:subject xml:lang="en">stigmastane-type steroids</dc:subject>
	<dc:description xml:lang="en">Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2020-12-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/15976</dc:identifier>
	<dc:identifier>10.15408/jkv.v6i2.15976</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI Volume 6, No. 2, November 2020; 133-139</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/15976/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Tri Mayanti</dc:rights>
</oai_dc:dc>