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Study of Physical Characteristic and Equivalence between Generic and Branded Name of Phenylbutazone Tablet

Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan · Vol. 3 No. 2 (2017)

DOI
10.33772/pharmauho.v3i2.3537
ISSN
2715-4181
Published
2017-09-16
Publisher
Fakultas Farmasi Universitas Halu Oleo
Language
eng

Abstract

Physical characterization and equivalence testing of generic and branded names of phenylbutazone tablets have been done. The information about quality of generic drugs is expected to increase the use of generic drugs by health practitioners and public. Dissolution test carried out by in vitro had correlation with bioequivalence by in vivo test. Sample of dissolution testing were generic (G) and branded (A and B) names of 200 mg phenylbutazone tablets. Physical characteristic test performed by uniformity weight test, hardness and disintegration time. Dissolution test were conducted by using basket and spectrophotometry ultra violet method in 200-400 nm wavelength. The result of uniformity weight of generic drug and branded drug was 352,02 mg and 352,82 mg, the hardness of generic was 9,58 kgf and branded was 9,50 kgf, and disintegration test result of generic was 16,1 minutes and branded was 3 minutes. The result of dissolution testing were dissolution profile and dissolved concentration at 30 minutes that compared to qualify of USP XXXII. Relative bioavailability testing of generic to A brand was 101.580 and generic to B brand was 105.275. Based on statistical test, there was no significant different or pharmaceutical equivalent. The generic tablets were equivalent to A and B branded names tablets with similar factors 82.120 and 74.271.Keywords: Equivalence, Dissolution, Salbutamol tablet; generic name, branded name

Collaboration network of the authors

40 authors · 103 co-authorship links · 2 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Halu Oleo
  • Hasanuddin University
  • Bandung Islamic University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Fery Indradewi ArmadanyAffiliation unknown3
Sandra Aulia MardikasariAffiliation unknown3
Suryani SuryaniUniversitas Halu Oleo2
Tasnim TasnimAffiliation unknown2
Imran - ImranAffiliation unknown2
Sugireng SugirengAffiliation unknown2
Muhammad Handoyo SahumenaUniversitas Halu Oleo2
Rifa'atul MahmudahAffiliation unknown2
H HalikAffiliation unknown2
R RamlahAffiliation unknown2
Endeng JuswitaAffiliation unknown2
Nurramadhani Armada SidaUniversitas Halu Oleo1
Sunandar IhsanUniversitas Halu Oleo1
Yamin YaminUniversitas Halu Oleo1
Arfan ArfanUniversitas Halu Oleo1
Novi NoviAffiliation unknown1
Ayu Sasta FiyanaAffiliation unknown1
Rini HamsidiAffiliation unknown1
Wahyuni WahyuniHasanuddin University1
N NovitasariUniversitas Halu Oleo1
R RahmasariUniversitas Halu Oleo1
Wa FiaUniversitas Halu Oleo1
Sitti AdawiaUniversitas Halu Oleo1
Dhidi Dharmadi HasanuddinUniversitas Halu Oleo1
Achmad FudholiAffiliation unknown1
Abdul RohmanBandung Islamic University1
Munirwan ZaniUniversitas Halu Oleo1
Rosmawaty RosmawatyUniversitas Halu Oleo1
Halimahtussaddiyah R Halimahtussaddiyah RAffiliation unknown1
Niken PrawestiAffiliation unknown1
SRI REJEKIUniversitas Halu Oleo1
La Ode HuliAffiliation unknown1
Laode Muhamad Hazairin NadiaAffiliation unknown1
La Ode Abdul Rajab NadiaAffiliation unknown1
Ririn AndrianiUniversitas Halu Oleo1
Muh Handoyo SahumenaUniversitas Halu Oleo1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/pharmauho/oai, first harvested 30 Oct 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Study of Physical Characteristic and Equivalence between Generic and Branded Name of Phenylbutazone Tablet</dc:title>
	<dc:creator>Akib, Nur Illiyyin</dc:creator>
	<dc:creator>Husnaeni, Husnaeni</dc:creator>
	<dc:creator>Zubaydah, Wa Ode Sitti</dc:creator>
	<dc:creator>Mallarangeng, Andi Nafisah Tendri Adjeng</dc:creator>
	<dc:description xml:lang="en-US">Physical characterization and equivalence testing of generic and branded names of phenylbutazone tablets have been done. The information about quality of generic drugs is expected to increase the use of generic drugs by health practitioners and public. Dissolution test carried out by in vitro had correlation with bioequivalence by in vivo test. Sample of dissolution testing were generic (G) and branded (A and B) names of 200 mg phenylbutazone tablets. Physical characteristic test performed by uniformity weight test, hardness and disintegration time. Dissolution test were conducted by using basket and spectrophotometry ultra violet method in 200-400 nm wavelength. The result of uniformity weight of generic drug and branded drug was 352,02 mg and 352,82 mg, the hardness of generic was 9,58 kgf and branded was 9,50 kgf, and disintegration test result of generic was 16,1 minutes and branded was 3 minutes. The result of dissolution testing were dissolution profile and dissolved concentration at 30 minutes that compared to qualify of USP XXXII. Relative bioavailability testing of generic to A brand was 101.580 and generic to B brand was 105.275. Based on statistical test, there was no significant different or pharmaceutical equivalent. The generic tablets were equivalent to A and B branded names tablets with similar factors 82.120 and 74.271.Keywords: Equivalence, Dissolution, Salbutamol tablet; generic name, branded name</dc:description>
	<dc:publisher xml:lang="en-US">Fakultas Farmasi Universitas Halu Oleo</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2017-09-16</dc:date>
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	<dc:identifier>https://ojs.uho.ac.id/index.php/pharmauho/article/view/3537</dc:identifier>
	<dc:identifier>10.33772/pharmauho.v3i2.3537</dc:identifier>
	<dc:source xml:lang="en-US">Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan; Vol 3, No 2 (2017): Pharmauho</dc:source>
	<dc:source>2715-4181</dc:source>
	<dc:source>10.33772/pharmauho.v3i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/pharmauho/article/view/3537/2672</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Pharmauho</dc:rights>
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