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Formulasi Sediaan Krim Anti Jerawat Ekstrak Etanol Biji Pepaya Muda (Carica papaya L.) Serta Uji Aktivitasnya Terhadap Bakteri Pseudomonas aeruginosaATCC 27825 dan Staphylococcus aureusATCC 25923 (Anti Acne Cream Formulation for Young Papaya Seed (Carica papaya L.) Ethanol Extract and Activity Test Against Pseudomonas aeruginosa ATCC 27825 and Staphylococcus aureus ATCC 25923)

MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) · Vol. 7 No. 1 (2020)

DOI
10.46496/medula.v7i1.11493
ISSN
2443-0218, 2339-1006
Published
2020-04-26
Publisher
Halu Oleo University
Language
eng

Abstract

Background: Young papaya seeds (Carica papaya L.) contained terpenoids, alkaloids karpain and flavonoids that have been examined has antibacterial activity. Purpose: This study aims to obtain anti-acne cream from extract of young papaya seeds (Carica papaya L.) that possess antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27825. Methods: Extract of young papaya seeds (Carica papaya L.) was obtained by maceration process using ethanol 96% and the antibacterial activity of extract conducted by well diffusion method. then the extract formulated into anti acne cream dosage and then tested to characteristic properties including pH test, dispersive power test, organoleptic test, homogeneity test, viscosity test and irritation test. Result: The results showed anti acne creams of extract young papaya seeds (Carica papaya L.) produced qualified standard and did not cause irritation. Conclusion: Anti acne cream containing extract concentration of 10% can inhibited bacteria of S. aureus ATCC 25923 with inhibition zone of 17,5 mm and P. aeruginosa ATCC 27825 with inhibition zone of 19,3 mm.Keyword: seeds of papaya (Carica papaya L.), anti acne creamLatar Belakang: Biji pepaya muda (Carica papaya L) mengandung terpenoid, alkaloid karpain dan flavonoid, yang telah diteliti memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk memperoleh sediaan krim anti jerawat dari ekstrak biji pepaya muda (Carica papaya L) yang memiliki aktivitas anti bakteri terhadap bakteri Staphylococcus aureus ATCC 25923 dan Pseudomonas aureginosa ATCC 27825. Metode: Ekstrak biji pepaya muda (Carica papaya L) diperoleh melalui proses maserasi menggunakan pelarut etanol 96%, serta uji aktivitas antibakteri ekstrak dilakukan dengan metode sumuran. Ekstrak selanjutnya diformulasikan menjadi sediaan krim anti jerawat dan dilakukan uji karakterisasi meliputi uji pH, uji daya sebar, uji organoleptik, uji homogenitas, uji viskositas dan uji iritasi. Hasil: Hasil pengamatan menunjukkan sediaan krim anti jerawat ekstrak biji pepaya muda (Carica papaya L) yang dihasilkan memenuhi syarat standar nilai pH, daya sebar dan viskositas. Hasil uji iritasi memperlihatkan formula krim tidak menimbulkan iritasi. Simpulan: Sediaan krim anti jerawat dengan konsentrasi ekstrak 10% dapat menghambat bakteri S.aureus ATCC 25923 dengan hambatan sebesar 17,5 mm dan P. aeruginosa ATCC 27825 dengan hambatan sebesar 19,3 mm.Kata Kunci: biji pepaya muda (Carica papaya L), krim anti jerawat

Collaboration network of the authors

40 authors · 153 co-authorship links · 1 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Halu Oleo
  • Hasanuddin University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
P ParawansahUniversitas Halu Oleo2
Sunandar IhsanUniversitas Halu Oleo2
Asriullah JabbarUniversitas Halu Oleo2
Ria Agus IkoUniversitas Halu Oleo2
Saida SaidaUniversitas Halu Oleo1
Amiruddin EsoUniversitas Halu Oleo1
Nurul Afifah YusranUniversitas Halu Oleo1
Wa Ode Chesaria F.AUniversitas Halu Oleo1
Indriyati IndriyatiUniversitas Halu Oleo1
Nuzul Aulia Fajarwati BUniversitas Halu Oleo1
Puteri Febriyanthi RachmanUniversitas Halu Oleo1
A ArismawatiUniversitas Halu Oleo1
Risky Sesa RiniAffiliation unknown1
Henny KasmawatiUniversitas Halu Oleo1
Mesi LeoritaUniversitas Halu Oleo1
Sahrul SabarudinUniversitas Halu Oleo1
Rusliati DamuUniversitas Halu Oleo1
Aswan SudimanUniversitas Halu Oleo1
Asmaidah JamsirUniversitas Halu Oleo1
Wa Ode HasniarUniversitas Halu Oleo1
Wanda SeptiyanaUniversitas Halu Oleo1
Siti MardianiUniversitas Halu Oleo1
Eno Retno ArianiUniversitas Halu Oleo1
Warda Ayu NingsihAffiliation unknown1
Mutmainna MutmainnaUniversitas Halu Oleo1
Yenti PurnamasariUniversitas Halu Oleo1
Lista Yul ZamrulUniversitas Halu Oleo1
Hartati HartatiAffiliation unknown1
Wahyuni WahyuniHasanuddin University1
Zakiyatul MahmudahAffiliation unknown1
La Ode Muhammad FitrawanUniversitas Halu Oleo1
S SabarudinUniversitas Halu Oleo1
Muhammad ArbaUniversitas Halu Oleo1
Wa Ode Sitti NurrokhmadhaniAffiliation unknown1
Fery Indradewi ArmadanyUniversitas Halu Oleo1
Aulif PratiwiUniversitas Halu Oleo1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/medula/oai, first harvested 31 Oct 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Formulasi Sediaan Krim Anti Jerawat Ekstrak Etanol Biji Pepaya Muda (Carica papaya L.) Serta Uji Aktivitasnya Terhadap Bakteri Pseudomonas aeruginosaATCC 27825 dan Staphylococcus aureusATCC 25923  (Anti Acne Cream Formulation for Young Papaya Seed (Carica papaya L.) Ethanol Extract and Activity Test Against Pseudomonas aeruginosa ATCC 27825 and Staphylococcus aureus ATCC 25923)</dc:title>
	<dc:creator>Nuralifah, Nuralifah</dc:creator>
	<dc:creator>Indradewi, Feri</dc:creator>
	<dc:creator>Parawansah, Parawansah</dc:creator>
	<dc:creator>Nasrun, Satriana</dc:creator>
	<dc:description xml:lang="en-US">Background: Young papaya seeds (Carica papaya L.) contained terpenoids, alkaloids karpain and flavonoids that have been examined has antibacterial activity. Purpose: This study aims to obtain anti-acne cream from extract of young papaya seeds (Carica papaya L.) that possess antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27825. Methods: Extract of young papaya seeds (Carica papaya L.) was obtained by maceration process using ethanol 96% and the antibacterial activity of extract conducted by well diffusion method. then the extract formulated into anti acne cream dosage and then tested to characteristic properties including pH test, dispersive power test, organoleptic test, homogeneity test, viscosity test and irritation test. Result: The results showed anti acne creams of extract young papaya seeds (Carica papaya L.) produced qualified standard and did not cause irritation. Conclusion: Anti acne cream containing extract concentration of 10% can inhibited bacteria of S. aureus ATCC 25923 with inhibition zone of 17,5 mm and P. aeruginosa ATCC 27825 with inhibition zone of 19,3 mm.Keyword: seeds of papaya (Carica papaya L.), anti acne creamLatar Belakang: Biji pepaya muda (Carica papaya L) mengandung terpenoid, alkaloid karpain dan flavonoid, yang telah diteliti memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk memperoleh sediaan krim anti jerawat dari ekstrak biji pepaya muda (Carica papaya L) yang memiliki aktivitas anti bakteri terhadap bakteri Staphylococcus aureus ATCC 25923 dan Pseudomonas aureginosa ATCC 27825. Metode: Ekstrak biji pepaya muda (Carica papaya L) diperoleh melalui proses maserasi menggunakan pelarut etanol 96%, serta uji aktivitas antibakteri ekstrak dilakukan dengan metode sumuran. Ekstrak selanjutnya diformulasikan menjadi sediaan krim anti jerawat dan dilakukan uji karakterisasi meliputi uji pH, uji daya sebar, uji organoleptik, uji homogenitas, uji viskositas dan uji iritasi. Hasil: Hasil pengamatan menunjukkan sediaan krim anti jerawat ekstrak biji pepaya muda (Carica papaya L) yang dihasilkan memenuhi syarat standar nilai pH, daya sebar dan viskositas. Hasil uji iritasi memperlihatkan formula krim tidak menimbulkan iritasi. Simpulan: Sediaan krim anti jerawat dengan konsentrasi ekstrak 10% dapat menghambat bakteri S.aureus ATCC 25923 dengan hambatan sebesar 17,5 mm dan P. aeruginosa ATCC 27825 dengan hambatan sebesar 19,3 mm.Kata Kunci: biji pepaya muda (Carica papaya L), krim anti jerawat</dc:description>
	<dc:publisher xml:lang="en-US">Halu Oleo University</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2020-04-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/medula/article/view/11493</dc:identifier>
	<dc:identifier>10.46496/medula.v7i1.11493</dc:identifier>
	<dc:source xml:lang="en-US">MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO); Vol 7, No 1 (2019)</dc:source>
	<dc:source>2443-0218</dc:source>
	<dc:source>2339-1006</dc:source>
	<dc:source>10.46496/medula.v7i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/medula/article/view/11493/8054</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 MEDULA</dc:rights>
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