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Analysis of Risk Factor Hypoalbuminemia on the Incidence of Hyponatremia in Children with Nephrotic Syndrome

MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) · Vol. 9 No. 2 (2022) · pp. 89–94

DOI
10.46496/medula.v9i2.25294
ISSN
2443-0218, 2339-1006
Published
2022-05-25
Publisher
Halu Oleo University
Language
eng

Abstract

Background: Nephrotic syndrome is a clinical condition characterized by massive proteinuria, hypoalbuminemia, edema and may be accompanied by hypercholesterolemia. Proteinuria in childhood nephrotic syndrome is mainly in the form of albuminuria. In nephrotic syndrome, electrolyte balance disorders can occur in the form of hyponatremia which can cause complications from asymptomatic clinical manifestations to death. Currently, there are not many studies on hyponatremia in nephrotic syndrome. Objective: To determined hypoalbumin as a risk factor for hyponatremia in children with nephrotic syndrome. Methods: This research was an analytic observational study using a case control design. The subjects consisted of 80 children diagnosed with nephrotic syndrome at the Children's Health Installation at the Dr. Sardjito in Yogyakarta. The data collected included serum albumin levels and sodium levels. Statistical test using Odds Ratio (OR)..Results: The results showed that hypoalbumin (p = 0.000; OR 13,5; 95% CI 3,395 – 53,68) was a risk factor for the incidence of hyponatremia in children with nephrotic syndrome at the Children's Health Unit, Dr. Sardjito General Hospital in Yogyakarta. Conclusion: Hypoalbumin is a risk factor for hyponatremia in children with nephrotic syndrome

Collaboration network of the authors

5 authors · 6 co-authorship links · 2 across different organisations

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  • Universitas Halu Oleo
  • Institut Agama Islam Negeri Kendari
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
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Co-authorOrganisationJoint articles
Raja Al Fath Widya IswaraUniversitas Halu Oleo1
Murni Safitri MUniversitas Halu Oleo1
Rahmawati RahmawatiInstitut Agama Islam Negeri Kendari1
Andi Noor Kholidha SyarifinUniversitas Halu Oleo1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/medula/oai, first harvested 31 Oct 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Analysis of Risk Factor Hypoalbuminemia on the Incidence of Hyponatremia in Children with Nephrotic Syndrome</dc:title>
	<dc:creator>Asfiah Udu, Waode Sitti</dc:creator>
	<dc:description xml:lang="en-US">Background: Nephrotic syndrome is a clinical condition characterized by massive proteinuria, hypoalbuminemia, edema and may be accompanied by hypercholesterolemia. Proteinuria in childhood nephrotic syndrome is mainly in the form of albuminuria. In nephrotic syndrome, electrolyte balance disorders can occur in the form of hyponatremia which can cause complications from asymptomatic clinical manifestations to death. Currently, there are not many studies on hyponatremia in nephrotic syndrome. Objective: To determined hypoalbumin as a risk factor for hyponatremia in children with nephrotic syndrome. Methods: This research was an analytic observational study using a case control design. The subjects consisted of 80 children diagnosed with nephrotic syndrome at the Children's Health Installation at the Dr. Sardjito in Yogyakarta. The data collected included serum albumin levels and sodium levels. Statistical test using Odds Ratio (OR). .Results: The results showed that hypoalbumin (p = 0.000 ; OR 13,5; 95% CI 3,395 – 53,68) was a risk factor for the incidence of hyponatremia in children with nephrotic syndrome at the Children's Health Unit, Dr. Sardjito General Hospital in Yogyakarta. Conclusion: Hypoalbumin is a risk factor for hyponatremia in children with nephrotic syndrome </dc:description>
	<dc:publisher xml:lang="en-US">Halu Oleo University</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2022-05-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
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	<dc:identifier>https://ojs.uho.ac.id/index.php/medula/article/view/25294</dc:identifier>
	<dc:identifier>10.46496/medula.v9i2.25294</dc:identifier>
	<dc:source xml:lang="en-US">MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO); Vol 9, No 2 (2022); 89-94</dc:source>
	<dc:source>2443-0218</dc:source>
	<dc:source>2339-1006</dc:source>
	<dc:source>10.46496/medula.v9i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/medula/article/view/25294/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 MEDULA</dc:rights>
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