PENENTUAN KADAR HAMBAT MINIMUM EKSTRAK ETANOL RIMPANG Etlingera alba (Blume) A. D. Poulsen TERHADAP BAKTERI PENYEBAB DIARE Cronobacter muytjensii DAN PENGEMBANGANNYA DALAM SEDIAAN GRANUL

Fristiohady, Adryan; Andriani, Rina; Ramadhani, Rizky Barkah; wahyuni, Wahyuni; Muzuni, Muzuni; Bafadal, Mentarry; Sani, Asrul; Aspadiah, Vica; Sari, Puspita; Sahidin, Sahidin

doi:10.33772/jstp.v5i5.15099

Journal

PENENTUAN KADAR HAMBAT MINIMUM EKSTRAK ETANOL RIMPANG Etlingera alba (Blume) A. D. Poulsen TERHADAP BAKTERI PENYEBAB DIARE Cronobacter muytjensii DAN PENGEMBANGANNYA DALAM SEDIAAN GRANUL

Jurnal Sains dan Teknologi Pangan · Vol. 5 No. 5 (2020)

DOI: 10.33772/jstp.v5i5.15099
ISSN: 2527-6271
Published: 2020-11-16
Publisher: JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO
Language: eng

Abstract

ABSTRACT This study aimed to determine the potential inhibition of ethanol extract of Etlingera alba rhizome against the Cronobacter muytjensiis bacteria and its development in a granule dosage form. Measurement of Minimum Inhibitory Concentration (MIC) using the Broth Microdilution method while granule formulation used the wet granulation method. The results of this study indicate a concentration of 32μg/mL in C. muytjensii as an inhibition of bacterial growth by looking at the absorbance value that was close to 0 and confirmed by spectrophotometric results to see the turbidity of each concentration. This study used 12 extract concentrations, namely 2, 4, 8, 16, 32, 64, 128, 256, 512, 102, and 4096 μg/mL. The granule formulation used 5% gelatin as a binder, Explotab® 4%, 1% magnesium stearate, aerosil PH 101 4%, and lactose ad. 100%. Tablets of ethanol extract of E. alba rhizome qualified for evaluation of weight uniformity and size uniformity evaluation tests.Keywords:Etlingera alba, MIC, granulABSTRAKPenelitian ini bertujuan untuk mengetahui potensi penghambatan ekstrak etanol rimpang Etlingera alba terhadap bakteriCronobacter muytjensiiserta pengembangannya dalam bentuk sediaan granul. Pengukuran Minimum Inhibitory Concentration (MIC) dengan metode Broth Microdilutiondan formulasi granul menggunakan metode granulasi basah.Hasil penelitian ini menunjukkan konsentrasi 32μg/mL pada C. muytjensii sebagai penghambatan pertumbuhan bakteri dengan melihat nilai absorbansi yang mendekati 0 dan dikonfirmasi dengan hasil spektrofotometri untuk melihat turbiditas masing-masing konsentrasi.Penelitian ini menggunakan 12 konsentrasi ekstrak yaitu 2, 4, 8, 16, 32, 64, 128, 256, 512, 102 dan 4096 μg/mL. Formulasi granul menggunakan bahan gelatin 5% sebagai pengikat, Explotab® 4%, magnesium stearat 1%, aerosil PH 101 4% dan laktosa ad. 100%. Tablet ekstrak etanol rimpangE. alba telah memenuhi uji evaluasi berupa keseragaman bobot dan uji evaluasi keseragaman ukuranKata kunci: Etlingera alba, MIC, granul

Collaboration network of the authors

40 authors · 135 co-authorship links · showing the 40 most connected

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Universitas Halu Oleo
Affiliation unknown

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Co-author	Organisation	Joint articles
Muhammad Hajrul Malaka	Affiliation unknown	8
Fadhliyah Malik	Affiliation unknown	7
M. Ridwan	Affiliation unknown	5
Rini Hamsidi	Affiliation unknown	5
Usman Arsyad	Affiliation unknown	4
Helmi Suryani Nasution	Affiliation unknown	4
Mustamin Anggo	Universitas Halu Oleo	3
La Ode Reskiaddin	Affiliation unknown	3
Sri Astuti Siregar	Affiliation unknown	3
Ismi Nurwaqiah Ibnu	Affiliation unknown	3
guspianto guspianto	Affiliation unknown	3
Solihin Sayuti	Affiliation unknown	3
Muhammad Rifqi Azhary	Affiliation unknown	3
Suryani Suryani	Universitas Halu Oleo	3
Dirvamena Boer	Universitas Halu Oleo	3
Ruslin Ruslin	Universitas Halu Oleo	3
Henny Kasmawati	Universitas Halu Oleo	3
Mukhsar Mukhsar	Affiliation unknown	3
Ida Usman	Affiliation unknown	3
Analuddin Analuddin	Universitas Halu Oleo	2
Suriana Suriana	Affiliation unknown	2
Jahidin Jahidin	Affiliation unknown	2
Hafiludin Samparadja	Affiliation unknown	2
Warhamni Warhamni	Affiliation unknown	2
Andang Suryana Soma	Affiliation unknown	2
Lia Nurdini	Affiliation unknown	2
Sri Ambardini	Universitas Halu Oleo	2
Jamili Jamili	Affiliation unknown	2
Sunandar Ihsan	Universitas Halu Oleo	2
SRI WAHYUNI	Affiliation unknown	2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/jstp/oai, first harvested 31 Oct 2026, last seen 31 Oct 2026.

Original metadata (oai_dc)

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	<dc:title xml:lang="en-US">PENENTUAN KADAR HAMBAT MINIMUM EKSTRAK ETANOL RIMPANG Etlingera alba (Blume) A. D. Poulsen TERHADAP BAKTERI PENYEBAB DIARE Cronobacter muytjensii DAN PENGEMBANGANNYA DALAM SEDIAAN GRANUL</dc:title>
	<dc:creator>Fristiohady, Adryan</dc:creator>
	<dc:creator>Andriani, Rina</dc:creator>
	<dc:creator>Ramadhani, Rizky Barkah</dc:creator>
	<dc:creator>wahyuni, Wahyuni</dc:creator>
	<dc:creator>Muzuni, Muzuni</dc:creator>
	<dc:creator>Bafadal, Mentarry</dc:creator>
	<dc:creator>Sani, Asrul</dc:creator>
	<dc:creator>Aspadiah, Vica</dc:creator>
	<dc:creator>Sari, Puspita</dc:creator>
	<dc:creator>Sahidin, Sahidin</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACT This study aimed to determine the potential inhibition of ethanol extract of Etlingera alba rhizome against the Cronobacter muytjensiis bacteria and its development in a granule dosage form. Measurement of Minimum Inhibitory Concentration (MIC) using the Broth Microdilution method while granule formulation used the wet granulation method. The results of this study indicate a concentration of 32μg/mL in C. muytjensii as an inhibition of bacterial growth by looking at the absorbance value that was close to 0 and confirmed by spectrophotometric results to see the turbidity of each concentration. This study used 12 extract concentrations, namely 2, 4, 8, 16, 32, 64, 128, 256, 512, 102, and 4096 μg/mL. The granule formulation used 5% gelatin as a binder, Explotab® 4%, 1% magnesium stearate, aerosil PH 101 4%, and lactose ad. 100%. Tablets of ethanol extract of E. alba rhizome qualified for evaluation of weight uniformity and size uniformity evaluation tests.Keywords:Etlingera alba, MIC, granulABSTRAKPenelitian ini bertujuan untuk mengetahui potensi penghambatan ekstrak etanol rimpang Etlingera alba terhadap bakteriCronobacter muytjensiiserta pengembangannya dalam bentuk sediaan granul. Pengukuran Minimum Inhibitory Concentration (MIC) dengan metode Broth Microdilutiondan formulasi granul menggunakan metode granulasi basah.Hasil penelitian ini menunjukkan konsentrasi 32μg/mL pada C. muytjensii sebagai penghambatan pertumbuhan bakteri dengan melihat nilai absorbansi yang mendekati 0 dan dikonfirmasi dengan hasil spektrofotometri untuk melihat turbiditas masing-masing konsentrasi.Penelitian ini menggunakan 12 konsentrasi ekstrak yaitu 2, 4, 8, 16, 32, 64, 128, 256, 512, 102 dan 4096 μg/mL. Formulasi granul menggunakan bahan gelatin 5% sebagai pengikat, Explotab® 4%, magnesium stearat 1%, aerosil PH 101 4% dan laktosa ad. 100%. Tablet ekstrak etanol rimpangE. alba telah memenuhi uji evaluasi berupa keseragaman bobot dan uji evaluasi keseragaman ukuranKata kunci: Etlingera alba, MIC, granul</dc:description>
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	<dc:date>2020-11-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
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	<dc:identifier>https://ojs.uho.ac.id/index.php/jstp/article/view/15099</dc:identifier>
	<dc:identifier>10.33772/jstp.v5i5.15099</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Sains dan Teknologi Pangan; Vol 5, No 5 (2020): Jurnal Sains dan Teknologi Pangan</dc:source>
	<dc:source>2527-6271</dc:source>
	<dc:source>10.33772/jstp.v5i5</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/jstp/article/view/15099/10292</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Jurnal Sains dan Teknologi Pangan</dc:rights>
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