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(Ointment Formulation from N-Hexane Extract of Majapahit Leaves (Crescentia cujete l.) and its Antibacterial Activity Evaluation against Pseudomonas aeruginosa)

MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) · Vol. 6 No. 3 (2019)

DOI
10.46496/medula.v6i3.9646
ISSN
2443-0218, 2339-1006
Published
2019-11-28
Publisher
Halu Oleo University
Language
eng

Abstract

ABSTRACT Background: Majapahit leaves (Crescentia cujete L.) are known to contain biochemical compounds namely tannins, terpenoids, alkaloids, and saponins which are effective as antimicrobials. Objective(s): This study aimed to formulate ointment from n-hexane extract of majapahit leaves and to known its antimicrobial activity against P. aeruginosa. Methods: ointment ingredients are vaselin, cera alba, liquid paraffin, and menthol and 2% of Majapahit leaves n-hexane extract. Ointment stability test included organoleptic, homogeneity, viscosity, pH, and irritation tests. Evaluation of stability of ointment was obtained by using cycling test method. The irritation test was carried out by open patch test on 6 panellists. Diffusion method is used to obtain antimicrobial activity. Results: The antimicrobial activity (diameter inhibition zone) of the ointment against Pseudomonas aeruginosa bacteria was 11 mm and the positive control was 13 mm. The formula showed no change on texture, colour, aroma, viscosity, homogeneity, but there was slight increase in viscosity and pH. The ointment showed non-irritating for panellists thus the ointment formulation is safe for topical use. Conclusion: 2% n-hexane extract of Majapahit leaves can be formulated into ointment with good stability with strong antibacterial activity and non-irritating. Keywords: antibacterial activity, majapahit leaves, N-hexane extract, ointment, Pseudomonas aeruginosa

Collaboration network of the authors

22 authors · 52 co-authorship links · 2 across different organisations

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  • Universitas Halu Oleo
  • Tadulako University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Herlina HerlinaUniversitas Halu Oleo1
Sri WahyuniUniversitas Halu Oleo1
Wa Ode Sitti MusninaTadulako University1
Ulfa WildaUniversitas Halu Oleo1
Ari SartinahUniversitas Halu Oleo1
Suryani SuryaniUniversitas Halu Oleo1
Nur illiyin AkibAffiliation unknown1
Andi Nafisah Tendri AdjengUniversitas Halu Oleo1
Halimahtussaddiyah RitongaUniversitas Halu Oleo1
Rahiswari Pramudita LakasaUniversitas Halu Oleo1
NUR ILLIYYIN AKIBUniversitas Halu Oleo1
Mariani TriwatamiUniversitas Halu Oleo1
Nur Arsianti AzizahUniversitas Halu Oleo1
Dwi Endah DesrianiUniversitas Halu Oleo1
Ririn WahyuniUniversitas Halu Oleo1
P ParawansahUniversitas Halu Oleo1
Nuralifah NuralifahUniversitas Halu Oleo1
Aulif PratiwiUniversitas Halu Oleo1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/medula/oai, first harvested 1 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">(Ointment Formulation from N-Hexane Extract of Majapahit Leaves (Crescentia cujete l.) and its Antibacterial Activity Evaluation against Pseudomonas aeruginosa)</dc:title>
	<dc:creator>Armadany, Fery I</dc:creator>
	<dc:creator>Putri, Andi E.P.</dc:creator>
	<dc:creator>Sasmin, Erlina D.</dc:creator>
	<dc:creator>Mallarangeng, Mallarangeng Andi N.T.A.</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACT Background:  Majapahit leaves (Crescentia cujete L.) are known to contain biochemical compounds namely tannins, terpenoids, alkaloids, and saponins which are effective as antimicrobials. Objective(s): This study aimed to formulate ointment from n-hexane extract of majapahit leaves and to known its antimicrobial activity against P. aeruginosa. Methods: ointment ingredients are vaselin, cera alba, liquid paraffin, and menthol and 2% of Majapahit leaves n-hexane extract. Ointment stability test included organoleptic, homogeneity, viscosity, pH, and irritation tests. Evaluation of stability of ointment was obtained by using cycling test method. The irritation test was carried out by open patch test on 6 panellists. Diffusion method is used to obtain antimicrobial activity. Results: The antimicrobial   activity    (diameter   inhibition   zone)   of    the    ointment    against Pseudomonas aeruginosa bacteria was 11 mm and the positive control was 13 mm. The formula showed no change on texture, colour, aroma, viscosity, homogeneity, but there was slight increase in viscosity and pH. The ointment showed non-irritating for panellists thus the ointment formulation is safe for topical use. Conclusion: 2% n-hexane extract of Majapahit leaves can be formulated into ointment with good stability with strong antibacterial activity and non-irritating. Keywords:  antibacterial  activity,  majapahit  leaves,  N-hexane  extract,  ointment,  Pseudomonas aeruginosa</dc:description>
	<dc:publisher xml:lang="en-US">Halu Oleo University</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2019-11-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/medula/article/view/9646</dc:identifier>
	<dc:identifier>10.46496/medula.v6i3.9646</dc:identifier>
	<dc:source xml:lang="en-US">MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO); Vol 6, No 3 (2019): Edisi Suplemen</dc:source>
	<dc:source>2443-0218</dc:source>
	<dc:source>2339-1006</dc:source>
	<dc:source>10.46496/medula.v6i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/medula/article/view/9646/6844</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 MEDULA</dc:rights>
</oai_dc:dc>