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Follicular Development of Aged Rats Ovarian Injected Human Umbilical Cord Mesenchymal Stem Cells

Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) · Vol. UME No. 1 (2020)

ISSN
2615-2835, 2614-0187
Published
2020-02-16
Publisher
Hasanuddin University
Language
en

Abstract

Female reproductive system showing the fastest signs of aging. The ovarian aging characterized by a decrease in follicular development. Stem cells are undifferentiated cells and can form a variety of different cells as the foundation of tissues and organs. Previous studies reported that Bone Marrow Mesenchymal Stem Cells (BM-MSCs) transplantation can restore follicular development in damaged ovarian rats. This study aimed to analyze the number of follicular development in aged rats and to analyze the capability of human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) to improving follicular development in aged rats. This study used 3 mature rats (4 months old), and 9 nine aged rats (22-24 months old), Spraque Dawley (SD) strain. They were divided into four groups. The first and the second group was mature rats and aged rats without injection. The third and the fourth group was aged rats injected hUC-MSCs dose 106 cells/kgBW and hUC-MSCs dose 107 cells/kgBW. The injection carried out 4 times at 3-month intervals. The parameters observed were follicular development and homing image of hUC-MSCs in ovarian tissue. The results showed that the number of follicular developments in aged rats 22-24 months decreased significantly compared to mature rats 4 months old. Injection of hUC-MSCs at dose 106 cells/kgBW and 107 cells/kgBW did not increase follicular development in aged rats. hUC-MSCs did not found in ovarian tissue. It could be concluded that aged rats 22-24 months old no longer productive indicated from the number of follicular developments and corpus luteum decreased. The injection of hUC-MSCs intravenously did not indicate an improvement of follicular development in aged rats 22-24 months old.

Keywords

Collaboration network of the authors

40 authors · 144 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • IPB University
  • Hasanuddin University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Harry MurtiAffiliation unknown6
Berry JuliandiAffiliation unknown5
Srihadi AgungpriyonoAffiliation unknown4
Muhammad RizalUniversitas Halu Oleo3
HERDISAffiliation unknown3
Mohamad Agus SetiadiAffiliation unknown3
Mokhamad FahrudinAffiliation unknown3
Hera MaheshwariAffiliation unknown3
Wasmen ManaluAffiliation unknown3
Niken UlupiIPB University2
Agik SuprayogiAffiliation unknown2
Desrayni HanadhitaAffiliation unknown2
ITA DJUWITAAffiliation unknown2
Takdir SailiAffiliation unknown2
. YulnawatiAffiliation unknown2
Vista BudiariatiAffiliation unknown2
Dwi BudionoAffiliation unknown2
Rizal RizalUniversitas Halu Oleo2
Annisa AmaliaAffiliation unknown2
Dwi Davidson RihibihaAffiliation unknown2
Wahyu WidowatiAffiliation unknown2
Ervi AfifahAffiliation unknown2
Sutiman Bambang SumitroAffiliation unknown2
Irma Herawati SupartoAffiliation unknown2
La JumadinAffiliation unknown1
NUR ISNAINI ULFAUniversitas Halu Oleo1
Savitri NovelinaAffiliation unknown1
Muhammad Ardiansyah NurdinHasanuddin University1
Huda Salahuddin DarusmanAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jrvi/oai, first harvested 3 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Follicular Development of Aged Rats Ovarian Injected Human Umbilical Cord Mesenchymal Stem Cells</dc:title>
	<dc:creator xml:lang="en">Dianti, Resti Rahma</dc:creator>
	<dc:creator xml:lang="en">Fitrianto, Alif Iman</dc:creator>
	<dc:creator xml:lang="en">Utami, Adkhilni</dc:creator>
	<dc:creator xml:lang="en">Astini, Wining</dc:creator>
	<dc:creator xml:lang="en">Dwijayanti, Adisti</dc:creator>
	<dc:creator xml:lang="en">Suyatna, Frans Dhyanagiri</dc:creator>
	<dc:creator xml:lang="en">Yaprianto, Kelvin</dc:creator>
	<dc:creator xml:lang="en">Bachtiar, Indra</dc:creator>
	<dc:creator xml:lang="en">Satyaningtijas, Aryani Sismin</dc:creator>
	<dc:creator xml:lang="en">Winarto, Adi</dc:creator>
	<dc:creator xml:lang="en">Boediono, Arief</dc:creator>
	<dc:subject xml:lang="en">ageing</dc:subject>
	<dc:subject xml:lang="en">estrogen</dc:subject>
	<dc:subject xml:lang="en">follicles</dc:subject>
	<dc:subject xml:lang="en">ovary</dc:subject>
	<dc:subject xml:lang="en">stem cells</dc:subject>
	<dc:description xml:lang="en">Female reproductive system showing the fastest signs of aging. The ovarian aging characterized by a decrease in follicular development. Stem cells are undifferentiated cells and can form a variety of different cells as the foundation of tissues and organs. Previous studies reported that Bone Marrow Mesenchymal Stem Cells (BM-MSCs) transplantation can restore follicular development in damaged ovarian rats. This study aimed to analyze the number of follicular development in aged rats and to analyze the capability of human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) to improving follicular development in aged rats. This study used 3 mature rats (4 months old), and 9 nine aged rats (22-24 months old), Spraque Dawley (SD) strain. They were divided into four groups. The first and the second group was mature rats and aged rats without injection. The third and the fourth group was aged rats injected hUC-MSCs dose 106 cells/kgBW and hUC-MSCs dose 107 cells/kgBW. The injection carried out 4 times at 3-month intervals. The parameters observed were follicular development and homing image of hUC-MSCs in ovarian tissue. The results showed that the number of follicular developments in aged rats 22-24 months decreased significantly compared to mature rats 4 months old. Injection of hUC-MSCs at dose 106 cells/kgBW and 107 cells/kgBW did not increase follicular development in aged rats. hUC-MSCs did not found in ovarian tissue. It could be concluded that aged rats 22-24 months old no longer productive indicated from the number of follicular developments and corpus luteum decreased. The injection of hUC-MSCs intravenously did not indicate an improvement of follicular development in aged rats 22-24 months old.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2020-02-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jrvi/article/view/6889</dc:identifier>
	<dc:source xml:lang="en">Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research); VOLUME 4 No. 1, JANUARY 2020</dc:source>
	<dc:source>2615-2835</dc:source>
	<dc:source>2614-0187</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jrvi/article/view/6889/4801</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research)</dc:rights>
</oai_dc:dc>