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IIn Silico Testing On The Activity Of Flavonol In Sterculia foetida Leaf As Natural Anti Hyperlipidemia Compounds

International Journal of Applied Biology · Vol. 6 No. 1 (2022) · pp. 144–148

ISSN
2580-2119, 2580-2410
Published
2022-07-07
Publisher
Hasanuddin University
Language
en

Abstract

This study aims to measure the biological activity of flavonols in the leaves of Sterculia foetida as an antihyperlipidemic drug. The chemical structure of flavonols contained in the leaves of Sterculia foetida was taken from the literature. The target protein used was 3-hydroxy 3-methylglutaryl coenzyme A reductase and the control was simvastatin. Water molecules have been removed with PyMol v2.5.2 Software. Docking between the target protein and flavonols was performed using PyRx-Python Prescription 0.8 Software. The results showed that flavonol compounds have greater potential for antihyperlipidemia compared to control compounds. The equivalent affinity of 3-hydroxy 3-methylglutaryl coenzyme A reductase for flavonols is -8.3, and the affinity of 3-hydroxy-3-methylglutaryl coenzyme A reductase for simvastatin is -7.9. Flavonol toxicity studies have shown that flavonols are not potentially carcinogenic and did not cause mutations. The absorption of flavonols in water was higher than that of the control compound.

Keywords

Collaboration network of the authors

35 authors · 99 co-authorship links

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  • Hasanuddin University
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Arif SantosoAffiliation unknown3
Irfan IdrisAffiliation unknown3
NindrahayuAffiliation unknown2
Ami FebrizaAffiliation unknown2
Andi Irwan MulukAffiliation unknown2
Rosdiana NatsirAffiliation unknown1
Desi Dwirosalia SuparmanAffiliation unknown1
Aryadi ArsyadAffiliation unknown1
Muhammad husni CangaraAffiliation unknown1
Ilhamjaya PatellongiAffiliation unknown1
Yulia Yusrini DjabirAffiliation unknown1
Sasmita SasmitaAffiliation unknown1
Andi Rahmaniar Suciani PujiningrumAffiliation unknown1
Ferly Christian PuahadiAffiliation unknown1
Erfan SutonoAffiliation unknown1
Andi Asda AstiahAffiliation unknown1
Syahrijuita SyahrijuitaAffiliation unknown1
Suryani As'adAffiliation unknown1
Aminuddin AminuddinAffiliation unknown1
Desya Faradila IsmiAffiliation unknown1
AminuddinAffiliation unknown1
Inggrid -Affiliation unknown1
Nurpudji A TaslimAffiliation unknown1
Padlianah PadlianahAffiliation unknown1
Mutmainah ArifAffiliation unknown1
M. Husni CangaraAffiliation unknown1
Yuyun WidaningsihHasanuddin University1
Liong Boy KurniawanAffiliation unknown1
Winda MulyaminAffiliation unknown1
Endy AdnanAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ijoab/oai, first harvested 3 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">IIn Silico Testing On The Activity Of Flavonol In Sterculia foetida Leaf As Natural Anti Hyperlipidemia Compounds</dc:title>
	<dc:creator xml:lang="en">Syam, Nindrahayu</dc:creator>
	<dc:creator xml:lang="en">Ariyandy, Andi</dc:creator>
	<dc:creator xml:lang="en">Yustisia, Ika</dc:creator>
	<dc:creator xml:lang="en">Sulfahri</dc:creator>
	<dc:creator xml:lang="en">Yusfina</dc:creator>
	<dc:subject xml:lang="en">antihyperlipidemia, Sterculia foetida, flavonols, 3-hydroxy-3-methylglutaryl coenzyme A reductase</dc:subject>
	<dc:subject xml:lang="en">This paper have been presented at the 1st ICoB 2021 on December 11, 2021 and got LoA</dc:subject>
	<dc:description xml:lang="en">This study aims to measure the biological activity of flavonols in the leaves of &amp;nbsp;Sterculia foetida as an antihyperlipidemic drug. The chemical structure of flavonols contained in the leaves of Sterculia foetida was taken from the literature. The target protein used was 3-hydroxy 3-methylglutaryl coenzyme A reductase and &amp;nbsp;the control was simvastatin. Water &amp;nbsp;molecules have been removed with PyMol &amp;nbsp;v2.5.2 Software. Docking between the target protein and flavonols was performed using PyRx-Python Prescription 0.8 Software. The results showed that flavonol compounds have greater potential for antihyperlipidemia compared to control compounds. The equivalent affinity of 3-hydroxy 3-methylglutaryl coenzyme A reductase for flavonols is -8.3, and the affinity of 3-hydroxy-3-methylglutaryl coenzyme A reductase for simvastatin is -7.9. Flavonol toxicity studies have shown that flavonols are not potentially carcinogenic and did not cause mutations. The absorption of flavonols in water was higher than that of the control compound.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2022-07-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ijoab/article/view/19918</dc:identifier>
	<dc:source xml:lang="en">International Journal of Applied Biology; Vol. 6 No. 1 (2022): International Journal of Applied Biology; 144-148</dc:source>
	<dc:source>2580-2119</dc:source>
	<dc:source>2580-2410</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ijoab/article/view/19918/8410</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 International Journal of Applied Biology</dc:rights>
</oai_dc:dc>