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Skin Brightening Effects of Ascorbic Acid with ACTISOLV™ Integration: A Longitudinal Analysis Using Repeated Measures ANOVA

Jurnal Matematika, Statistika dan Komputasi · Vol. 22 No. 2 (2026) · pp. 395–406

DOI
10.20956/j.v22i2.47838
ISSN
2614-8811, 1858-1382
Published
2026-01-10
Publisher
Department of Mathematics, Hasanuddin University
Language
en
License
creativecommons.org/licenses/by/4.0

Abstract

Ascorbic Acid is a well-established active ingredient recognized for its efficacy in skin brightening and its antioxidant properties. However, its low chemical stability in cosmetic formulations remains a significant limitation. In response to this challenge, the patent-pending ACTISOLV™ formulation technology has been developed to enhance the stability of Ascorbic Acid, improving its resistance to oxidation and effectiveness in inhibiting melanin production. This study contributes to the advancement of sustainable cosmetic science through the development of more stable, eco-friendly, and sustainable skincare products. This study aimed to evaluate the longitudinal effects of a cream containing 20% Ascorbic Acid formulated with ACTISOLV™ on skin brightness. This study used longitudinal experimental data analyzed by Repeated Measures ANOVA. The results demonstrated a statistically significant increase in skin brightness over time (p-value = 0.000 < 0.05). Posthoc analysis revealed that skin brightness at weeks 6 and 12 differed significantly from baseline. However, no significant difference was found between the control and treatment groups and no significant interaction was observed between time and treatment group. These findings suggest that the observed improvement in skin brightness occurred similarly in both groups, indicating no additional effect attributable to the test formulation.

Keywords

Collaboration network of the authors

40 authors · 126 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Airlangga
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Suliyanto SuliyantoUniversitas Airlangga4
Anisah Nabilah GhasaniUniversitas Airlangga3
Nur ChamidahUniversitas Airlangga2
Ardi KurniawanUniversitas Airlangga2
Elly AnaUniversitas Airlangga2
Najwa Khoir AldawiyahUniversitas Airlangga2
Berliani LarasatiUniversitas Airlangga1
Qumadha Zaenal AbidinAffiliation unknown1
Juan Krisfigo PrasetyoUniversitas Airlangga1
Alma Khalisa RahmaUniversitas Airlangga1
Steven SoewignjoUniversitas Airlangga1
Ni Wayan Widya Septia SariUniversitas Airlangga1
Andini Putri MedianiUniversitas Airlangga1
M. Aqil Zaidan KamilUniversitas Airlangga1
Rosidun Nindyo PratiwiUniversitas Airlangga1
Nathania FauziahUniversitas Airlangga1
Bimo Okta SyahputraUniversitas Airlangga1
Ahmad Wahyu FirmandaUniversitas Airlangga1
Galuh Cahya NugrahaUniversitas Airlangga1
Billy Christandy SuyonoUniversitas Airlangga1
Idrus SyahzaqiUniversitas Airlangga1
Muhammad Rosyid Ridho Az ZuhroUniversitas Airlangga1
Sediono SedionoUniversitas Airlangga1
Tentri Ryan RahmanitaUniversitas Airlangga1
Kimberly Maserati SiagianUniversitas Airlangga1
Nadinta Kasih AmaliaUniversitas Airlangga1
Nadya Lovita Hana TrisaUniversitas Airlangga1
Gabriella Agnes BudijonoUniversitas Airlangga1
Rere Fetri DamanikUniversitas Airlangga1
Azizah Atsariyyah ZhafiraUniversitas Airlangga1
Azzah Nazhifa Wina RamadhaniAffiliation unknown1
Aulia RamadhantiAffiliation unknown1
M. Nabil SaputraUniversitas Airlangga1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmsk/oai, first harvested 5 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Skin Brightening Effects of Ascorbic Acid with ACTISOLV™ Integration: A Longitudinal Analysis Using Repeated Measures ANOVA</dc:title>
	<dc:creator xml:lang="en">Amelia, Dita</dc:creator>
	<dc:creator xml:lang="en">Suliyanto, Suliyanto</dc:creator>
	<dc:creator xml:lang="en">Mahadesyawardani, Arinda</dc:creator>
	<dc:creator xml:lang="en">Azizah, Nur</dc:creator>
	<dc:creator xml:lang="en">Ariyawan, Jovansha</dc:creator>
	<dc:creator xml:lang="en">Adiputra, R. Arya Januarta</dc:creator>
	<dc:creator xml:lang="en">Adyatma, Irsyad Yoga</dc:creator>
	<dc:subject xml:lang="en">Ascorbic Acid</dc:subject>
	<dc:subject xml:lang="en">Longitudinal Data</dc:subject>
	<dc:subject xml:lang="en">Repeated Measures ANOVA</dc:subject>
	<dc:subject xml:lang="en">Skin Brightening</dc:subject>
	<dc:description xml:lang="en">Ascorbic Acid is a well-established active ingredient recognized for its efficacy in skin brightening and its antioxidant properties. However, its low chemical stability in cosmetic formulations remains a significant limitation. In response to this challenge, the patent-pending ACTISOLV™ formulation technology has been developed to enhance the stability of Ascorbic Acid, improving its resistance to oxidation and effectiveness in inhibiting melanin production. This study contributes to the advancement of sustainable cosmetic science through the development of more stable, eco-friendly, and sustainable skincare products. This study aimed to evaluate the longitudinal effects of a cream containing 20% Ascorbic Acid formulated with ACTISOLV™ on skin brightness. This study used longitudinal experimental data analyzed by Repeated Measures ANOVA. The results demonstrated a statistically significant increase in skin brightness over time (p-value = 0.000 &amp;lt; 0.05). Posthoc analysis revealed that skin brightness at weeks 6 and 12 differed significantly from baseline. However, no significant difference was found between the control and treatment groups and no significant interaction was observed between time and treatment group. These findings suggest that the observed improvement in skin brightness occurred similarly in both groups, indicating no additional effect attributable to the test formulation.</dc:description>
	<dc:publisher xml:lang="en">Department of Mathematics, Hasanuddin University</dc:publisher>
	<dc:date>2026-01-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmsk/article/view/47838</dc:identifier>
	<dc:identifier>10.20956/j.v22i2.47838</dc:identifier>
	<dc:source xml:lang="en">Jurnal Matematika, Statistika dan Komputasi; Vol. 22 No. 2 (2026): JANUARY 2026; 395-406</dc:source>
	<dc:source>2614-8811</dc:source>
	<dc:source>1858-1382</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmsk/article/view/47838/13992</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Jurnal Matematika, Statistika dan Komputasi</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>