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STUDY OF COMPOUNDS FROM EXTRACT OF Melochia umbellata (Houtt.) Stapf var. Degrabrata K. (PALIASA) LEAVES THAT HAS POTENTIAL AS ANTIBACTERIAL

Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) · Vol. ume No. 1 (2015) · pp. 1–9

DOI
10.70561/ica.v8i1.2472
ISSN
2655-6049, 2085-014X
Published
2015-06-01
Publisher
Hasanuddin University
Language
en

Abstract

Determination of antibacterial activity of each extract of M. umbellata (Houtt.) Stapf var. K. degrabrata leaves has been conducted against three strains bacteria Escherichia coli, Staphylococcus aureus, and Shigella dysenteriae by using amoxicillin as a positive control and DMSO as a negative control. Agar diffusion method has been used with MHA medium (Muller Hinton Agar) on variation concentrations of each extract were 2500 ppm, 5000 ppm, 10,000 ppm, and 20,000 ppm N-hexane extract was the most active extract against S. aureus with zone of inhibitions were 10.50 mm, 10.80 mm, 11.00 mm and 11.45 mm, respectively. The most active extract against S. dysenteriae was ethyl acetate extracts with zone of inhibitions were 9.36 mm, 11.55 mm, 11.58 mm and 17.70 mm, respectively. Isolated compound from n-hexane extract was first compound as white powder with a melting point of 75-77 °C which was identified as 1-Tetracosanol and second compound was obtained in the form of a yellow paste which was identified as steroid compound that had long conjugated substituent. These compounds were elucidated based on the data of IR, UV-Vis, 1H-NMR, and 13C-NMR.

Keywords

Collaboration network of the authors

40 authors · 140 co-authorship links · showing the 40 most connected

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  • Sriwijaya University
  • Hasanuddin University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Seniwati DaliAffiliation unknown8
Ahyar AhmadAffiliation unknown6
Zainal AzwarAffiliation unknown4
Paulina TabaHasanuddin University4
ABDUL KARIMAffiliation unknown4
Siti NurmainiSriwijaya University3
Bambang TutukoSriwijaya University3
Ade Iriani SapitriSriwijaya University3
Muhammad Naufal RachmatullahSriwijaya University3
Annisa DarmawahyuniSriwijaya University3
Erwin AnshariAffiliation unknown3
Muhammad ZakirHasanuddin University3
Anggun IslamiSriwijaya University2
Wd Rizky AwaliahAffiliation unknown2
Muawanah MuawanahAffiliation unknown2
Indah RayaAffiliation unknown2
La KoloAffiliation unknown2
Sartika DanialAffiliation unknown2
Imam FakhruddinAffiliation unknown2
Zulfan ZulfanAffiliation unknown2
Djabal Nur BasirHasanuddin University2
St FauziahAffiliation unknown2
Syaharuddin KasimAffiliation unknown2
Yusafir HalaAffiliation unknown2
Desi SukentiAffiliation unknown2
Syahraini TambakAffiliation unknown2
Harningsih KarimAffiliation unknown2
Maswati BaharuddinAffiliation unknown2
Hanapi UsmanAffiliation unknown2
Nunuk Hariani SoekamtoAffiliation unknown2
Akhiar Wista ArumSriwijaya University1
Ghita AthalinaAffiliation unknown1
Muhammad Alpim Alfa RolisAffiliation unknown1
Almin AlminAffiliation unknown1
Muhammad AchidaAffiliation unknown1
Laode Muhammad BuyungAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ica/oai, first harvested 5 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">STUDY OF COMPOUNDS FROM EXTRACT OF Melochia umbellata (Houtt.) Stapf var. Degrabrata K. (PALIASA) LEAVES THAT HAS POTENTIAL AS ANTIBACTERIAL</dc:title>
	<dc:creator xml:lang="en">Wullur, Selfi</dc:creator>
	<dc:creator xml:lang="en">Firdaus, Firdaus</dc:creator>
	<dc:creator xml:lang="en">Natsir, Hasnah</dc:creator>
	<dc:creator xml:lang="en">Hariani Soekamto, Nunuk</dc:creator>
	<dc:subject xml:lang="en">1-Tetracosanol</dc:subject>
	<dc:subject xml:lang="en">antibacterial</dc:subject>
	<dc:subject xml:lang="en">phytochemical</dc:subject>
	<dc:subject xml:lang="en">Melochia umbellata</dc:subject>
	<dc:subject xml:lang="en">steroid</dc:subject>
	<dc:description xml:lang="en">Determination of antibacterial activity of each extract of M. umbellata (Houtt.) Stapf var. K. degrabrata leaves has been conducted against three strains bacteria Escherichia coli, Staphylococcus aureus, and Shigella dysenteriae by using amoxicillin as a positive control and DMSO as a negative control. Agar diffusion method has been used with MHA medium (Muller Hinton Agar) on variation concentrations of each extract were 2500 ppm, 5000 ppm, 10,000 ppm, and 20,000 ppm N-hexane extract was the most active extract against S. aureus with zone of inhibitions were 10.50 mm, 10.80 mm, 11.00 mm and 11.45 mm, respectively. The most active extract against S. dysenteriae was ethyl acetate extracts with zone of inhibitions were 9.36 mm, 11.55 mm, 11.58 mm and 17.70 mm, respectively. Isolated compound from n-hexane extract was first compound as white powder with a melting point of 75-77 °C which was identified as 1-Tetracosanol and second compound was obtained in the form of a yellow paste which was identified as steroid compound that had long conjugated substituent. These compounds were elucidated based on the data of IR, UV-Vis, 1H-NMR, and 13C-NMR.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2015-06-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ica/article/view/2472</dc:identifier>
	<dc:identifier>10.70561/ica.v8i1.2472</dc:identifier>
	<dc:source xml:lang="en">Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta); Volume 8 No 1 - June 2015; 1-9</dc:source>
	<dc:source>2655-6049</dc:source>
	<dc:source>2085-014X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ica/article/view/2472/1340</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2017 Indonesia Chimica Acta</dc:rights>
</oai_dc:dc>