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IL-1β Expression of Patients with Chronic Rhinosinusitis is negatively correlated with Lund-Mackay score

Nusantara Medical Science Journal · Vol. ume (2022) · pp. 74–82

DOI
10.20956/nmsj.v6i2.18765
ISSN
2597-7288, 2460-9757
Published
2022-01-03
Publisher
Faculty of Medicine, Hasanuddin University.
Language
en
License
creativecommons.org/licenses/by/4.0

Abstract

Introduction: IL-1β is one of the proinflammatory cytokines which is commonly found in various diseases, including Chronic Rhinosinusitis (CRS). It has been widely targeted as a therapeutic approach for inflammatory diseases. However, study of IL-1β expression and its correlation with CT-Scan grading scores in CRS is still scarce. Objective: To investigate IL-1β expression based on immunohistochemical examination and analyse its correlation with Lund-Mackay score in CRS with and without polyps. Method: This analytic observational study was done on 50 patients: 25 subjects in the CRS with Nasal Polyps (CRSwNP) group and 25 subjects in the CRS without Nasal Polyps (CRSsNP) group. The uncinate process was taken for immunohistochemical examination of IL-1β. Lund-Mackay score was calculated based on CT-Scan of the paranasal sinus. Result: IL-1β expression in CRSsNP (mean=36.38) was significantly higher than that in the CRSwNP (mean=14.62) with p<0.001. Lund-Mackay score in CRSwNP was higher (mean=35.22) compared to CRSnNP group (mean=15.78) with p<0.001. There was a moderate negative correlation (-0.403) between IL-1β expression and Lund-Mackay score (p<0.05). Conclusion: There was a moderate negative correlation between IL-1β expression and Lund-Mackay score. The IL-1β and the Lund-Mackay score in CRSwNP were lower and higher, respectively, than in CRSsNP

Collaboration network of the authors

40 authors · 146 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Nurhaedar JafarAffiliation unknown5
Citrakesumasari .Affiliation unknown3
Veni HadjuAffiliation unknown3
Safrullah AmirAffiliation unknown2
Abdul KadirUniversitas Halu Oleo2
Muhammad Fajar PerkasaAffiliation unknown2
Sabrina YasinAffiliation unknown1
Citra KesumasariAffiliation unknown1
Anna KhuzaimahAffiliation unknown1
Harlinah HarlinahAffiliation unknown1
Nur Amaliah rahmadaniAffiliation unknown1
Djunaedi M DachlanAffiliation unknown1
ezha widnatusifahAffiliation unknown1
sabaria battungAffiliation unknown1
Marini AmaliaAffiliation unknown1
Aminuddin SyamAffiliation unknown1
Devintha ViraniAffiliation unknown1
DWI YUNIATY ISMAILAffiliation unknown1
Hardianti .Affiliation unknown1
Marini Amalia MansurAffiliation unknown1
Sabaria MantiAffiliation unknown1
Saifuddin SirajuddinAffiliation unknown1
HarianiAffiliation unknown1
Marini Amaliah MansurAffiliation unknown1
Risnah BAffiliation unknown1
Healthy HidayantyAffiliation unknown1
Kurnia RabbiAffiliation unknown1
Rahayu IndriasariAffiliation unknown1
Michael SatriaAffiliation unknown1
Peter KaboAffiliation unknown1
Akhtar F. MuzakkirAffiliation unknown1
Muzakkir AmirAffiliation unknown1
Khalid SalehAffiliation unknown1
Aussie Fitriani GhaznawieAffiliation unknown1
Frizt A. TandeanAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">IL-1β Expression of Patients with Chronic Rhinosinusitis is negatively correlated with Lund-Mackay score</dc:title>
	<dc:creator xml:lang="en">Turupadang, Lidya</dc:creator>
	<dc:creator xml:lang="en">Perkasa, Muhammad Fadjar</dc:creator>
	<dc:creator xml:lang="en">Punagi, Abdul Qadar</dc:creator>
	<dc:creator xml:lang="en">Zakiah, Azmi Mi'rah</dc:creator>
	<dc:creator xml:lang="en">Bahar, Burhanuddin</dc:creator>
	<dc:description xml:lang="en">
Introduction: IL-1β is one of the proinflammatory cytokines which is commonly found in various diseases, including Chronic Rhinosinusitis (CRS). It has been widely targeted as a therapeutic approach for inflammatory diseases. However, study of IL-1β expression and its correlation with CT-Scan grading scores in CRS is still scarce. Objective: To investigate IL-1β expression based on immunohistochemical examination and analyse its correlation with Lund-Mackay score in CRS with and without polyps. Method: This analytic observational study was done on 50 patients: 25 subjects in the CRS with Nasal Polyps (CRSwNP) group and 25 subjects in the CRS without Nasal Polyps (CRSsNP) group. The uncinate process was taken for immunohistochemical examination of IL-1β. Lund-Mackay score was calculated based on CT-Scan of the paranasal sinus. Result: IL-1β expression in CRSsNP (mean=36.38) was significantly higher than that in the CRSwNP (mean=14.62) with p&amp;lt;0.001. Lund-Mackay score in CRSwNP was higher (mean=35.22) compared to CRSnNP group (mean=15.78) with p&amp;lt;0.001. There was a moderate negative correlation (-0.403) between IL-1β expression and Lund-Mackay score (p&amp;lt;0.05). Conclusion: There was a moderate negative correlation between IL-1β expression and Lund-Mackay score. The IL-1β and the Lund-Mackay score in CRSwNP were lower and higher, respectively, than in CRSsNP
</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2022-01-03</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/18765</dc:identifier>
	<dc:identifier>10.20956/nmsj.v6i2.18765</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 6 Issue 2, July - December 2021; 74-82</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.v6i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/18765/7674</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Nusantara Medical Science Journal</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>