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Prevalence and Risk Factors and Efforts to Reduce Dengue Fever and Dengue Hemorrhagic Fever Infections at PKU Muhammadiyah Gamping Hospital, Yogyakarta

Media Kesehatan Masyarakat Indonesia · Vol. 21 No. 4 (2025) · pp. 370–378

DOI
10.65844/mkmi.v21i4.47066
ISSN
2356-4067, 0216-2482
Published
2025-12-31
Publisher
Faculty of Public Health, Hasanuddin University, Makassar
Language
en
License
creativecommons.org/licenses/by-nc-sa/4.0/

Abstract

The incidence of Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF) has increased sharply in recent decades, making these infections endemic in several parts of the world. The purpose of this study was to analyze the prevalence, risk factors, and efforts to reduce DF and DHF infections at PKU Muhammadiyah Gamping Hospital, Yogyakarta. This study employed an observational cross-sectional design. The study sample consisted of patients diagnosed with DF or DHF at general hospitals in Yogyakarta between January 2019 and December 2023 who met the inclusion and exclusion criteria. Patients with a DF or DHF diagnosis but incomplete data were excluded. Sampling was conducted using a consecutive sampling method, retrieving information from patient data recorded in medical records. The research obtained ethical approval from the PKU Muhammadiyah Gamping Hospital Ethics Committee under permit number 054/KEP-PKU/II/2024. A p-value of 0.005 indicates a correlation between the incidence of DF DHF and liver illness. The value of OR is 4.660. A p-value of 0.006 indicates a correlation between the occurrence of DF DHF and corticosteroid therapy. This study found that the incidence of Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF) was correlated with diabetes, hypertension, kidney disease, and asthma/chronic lung disease, which were protective factors. However, liver disease and a history of corticosteroid therapy were identified as significant risk factors. These findings suggest that impaired liver function and long-term corticosteroid use may impair the immune response, increasing susceptibility to dengue infection and its severe manifestations. Therefore, clinical management and prevention strategies should prioritize monitoring of patients with liver impairment or those undergoing corticosteroid therapy, especially in dengue-endemic areas.

Keywords

Collaboration network of the authors

15 authors · 29 co-authorship links · 5 across different organisations

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Muhammadiyah University of Yogyakarta
  • University of Cyberjaya
  • University of Indonesia
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
K. KuntamanAffiliation unknown1
WJ. PudjirahardjoAffiliation unknown1
Prima WidayaniAffiliation unknown1
Tri Wulandari KesetyaningsihAffiliation unknown1
Warih Andan PuspitosariAffiliation unknown1
Kellyana KellyanaAffiliation unknown1
Amal Chalik SjaafAffiliation unknown1
Adang BachtiarAffiliation unknown1
Merita AriniAffiliation unknown1
Anhari AchadiUniversity of Indonesia1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/mkmi/oai, first harvested 5 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Prevalence and Risk Factors and Efforts to Reduce Dengue Fever and Dengue Hemorrhagic Fever Infections at PKU Muhammadiyah Gamping Hospital, Yogyakarta</dc:title>
	<dc:creator xml:lang="en">Kusbaryanto, Kusbaryanto</dc:creator>
	<dc:creator xml:lang="en">bin Abdurrahman , Abdurrasyid</dc:creator>
	<dc:creator xml:lang="en">Listiowati , Ekorini</dc:creator>
	<dc:creator xml:lang="en">Alam Romadhon , Yusuf</dc:creator>
	<dc:creator xml:lang="en">Rosyida , Aisyah</dc:creator>
	<dc:subject xml:lang="en">Prevalence</dc:subject>
	<dc:subject xml:lang="en">Risk Factors</dc:subject>
	<dc:subject xml:lang="en">Dengue Fever</dc:subject>
	<dc:subject xml:lang="en">Dengue Hemorrhagic Fever</dc:subject>
	<dc:subject xml:lang="en">Hospital</dc:subject>
	<dc:description xml:lang="en">The incidence of Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF) has increased sharply in recent decades, making these infections endemic in several parts of the world. The purpose of this study was to analyze the prevalence, risk factors, and efforts to reduce DF and DHF infections at PKU Muhammadiyah Gamping Hospital, Yogyakarta. This study employed an observational cross-sectional design. The study sample consisted of patients diagnosed with DF or DHF at general hospitals in Yogyakarta between January 2019 and December 2023 who met the inclusion and exclusion criteria. Patients with a DF or DHF diagnosis but incomplete data were excluded. Sampling was conducted using a consecutive sampling method, retrieving information from patient data recorded in medical records. The research obtained ethical approval from the PKU Muhammadiyah Gamping Hospital Ethics Committee under permit number 054/KEP-PKU/II/2024. A p-value of 0.005 indicates a correlation between the incidence of DF DHF and liver illness. The value of OR is 4.660. A p-value of 0.006 indicates a correlation between the occurrence of DF DHF and corticosteroid therapy. This study found that the incidence of Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF) was correlated with diabetes, hypertension, kidney disease, and asthma/chronic lung disease, which were protective factors. However, liver disease and a history of corticosteroid therapy were identified as significant risk factors. These findings suggest that impaired liver function and long-term corticosteroid use may impair the immune response, increasing susceptibility to dengue infection and its severe manifestations. Therefore, clinical management and prevention strategies should prioritize monitoring of patients with liver impairment or those undergoing corticosteroid therapy, especially in dengue-endemic areas.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Public Health, Hasanuddin University, Makassar</dc:publisher>
	<dc:date>2025-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/mkmi/article/view/47066</dc:identifier>
	<dc:identifier>10.65844/mkmi.v21i4.47066</dc:identifier>
	<dc:source xml:lang="en">Media Kesehatan Masyarakat Indonesia; Vol. 21 No. 4: DECEMBER 2025; 370-378</dc:source>
	<dc:source>2356-4067</dc:source>
	<dc:source>0216-2482</dc:source>
	<dc:source>10.30597/mkmi.v21i4</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/mkmi/article/view/47066/14092</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 by author</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc-sa/4.0/</dc:rights>
</oai_dc:dc>