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Potensi Senyawa Bioaktif dari Bajakah Spatholobus littoralis Hassk. Sebagai Antikanker terhadap Sel MCF-7 secara In Vitro

Jurnal Ilmu Alam dan Lingkungan · Vol. 16 No. 2 (2025)

DOI
10.70561/jal.v16i2.46542
ISSN
2549-8819, 2086-4604
Published
2025-08-27
Publisher
Universitas Hasanuddin
Language
en

Abstract

Bajakah (Spatholobus littoralis Hassk.) is a plant from the Angiospermae group, belonging to the Leguminosae family, that grows in Kalimantan. This plant contains secondary metabolites with potential anticancer activity. Cancer is characterized by uncontrolled cell proliferation beyond normal mechanisms, leading to abnormal tissue growth and invasion. It is one of the leading causes of death worldwide, including breast cancer. In 2022, approximately 2.3 million women were diagnosed with breast cancer, with 670,000 deaths recorded globally, while around 1.63 million women were still living with the disease by the end of the year. This study aimed to evaluate the anticancer activity of Bajakah Spatholobus littoralis Hassk. against MCF-7 breast cancer cells using the MTS assay. The results showed that Bajakah extract exhibited low toxicity toward the MCF-7 cell line, with an IC50 value of 1,098.77 ppm. Therefore, it can be concluded that Bajakah Spatholobus littoralis Hassk., tested with the MTS method, is not cytotoxic to breast cancer cells. Further studies are recommended to investigate its potential effects on other cancer cell types

Collaboration network of the authors

34 authors · 67 co-authorship links

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Gadjah Mada
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Fitriyani FitriyaniAffiliation unknown1
Warno WarnoAffiliation unknown1
Eva JohannesAffiliation unknown1
SulfahriAffiliation unknown1
Deasy Ovi HarsachatriAffiliation unknown1
Willy Anthony IqnatiusAffiliation unknown1
Yolanda AdistinAffiliation unknown1
Farida Nur AiniAffiliation unknown1
Muh. SholehAffiliation unknown1
Nanang IndardiAffiliation unknown1
Vacktian Diva GumalaAffiliation unknown1
Fitri Amalia ShintasiwiAffiliation unknown1
Ferani MulianingsihAffiliation unknown1
Shafarina SariAffiliation unknown1
Aprillia FindayaniAffiliation unknown1
Nanda Julian UtamaAffiliation unknown1
Dimas Nur RahmanAffiliation unknown1
Fajar HidayatullahAffiliation unknown1
Elsa Durotul FaridahAffiliation unknown1
Febriarti Setiya Putri FebriAffiliation unknown1
Istianah MahfudAffiliation unknown1
Nazilatul MunafiahAffiliation unknown1
Ruli AndriyantoAffiliation unknown1
Arif RahmanUniversitas Gadjah Mada1
Jamaluddin JamaluddinAffiliation unknown1
Ahmad SanusiAffiliation unknown1
Yusuf SomawinataAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jai2/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Potensi Senyawa Bioaktif dari Bajakah Spatholobus littoralis Hassk. Sebagai Antikanker terhadap Sel MCF-7 secara In Vitro </dc:title>
	<dc:creator xml:lang="en">Habibi, Alif Rahman</dc:creator>
	<dc:creator xml:lang="en">Arfan, Alya Rahmaditya</dc:creator>
	<dc:creator xml:lang="en">Anwar, Khoirul</dc:creator>
	<dc:creator xml:lang="en">Azizah, Anggia</dc:creator>
	<dc:creator xml:lang="en">Fathia, Mona</dc:creator>
	<dc:creator xml:lang="en">Winanda, Witri</dc:creator>
	<dc:creator xml:lang="en">Berlyansyah, Azizul</dc:creator>
	<dc:description xml:lang="en">Bajakah (Spatholobus littoralis Hassk.) is a plant from the Angiospermae group, belonging to the Leguminosae family, that grows in Kalimantan. This plant contains secondary metabolites with potential anticancer activity. Cancer is characterized by uncontrolled cell proliferation beyond normal mechanisms, leading to abnormal tissue growth and invasion. It is one of the leading causes of death worldwide, including breast cancer. In 2022, approximately 2.3 million women were diagnosed with breast cancer, with 670,000 deaths recorded globally, while around 1.63 million women were still living with the disease by the end of the year. This study aimed to evaluate the anticancer activity of Bajakah Spatholobus littoralis Hassk. against MCF-7 breast cancer cells using the MTS assay. The results showed that Bajakah extract exhibited low toxicity toward the MCF-7 cell line, with an IC50 value of 1,098.77 ppm. Therefore, it can be concluded that Bajakah Spatholobus littoralis Hassk., tested with the MTS method, is not cytotoxic to breast cancer cells. Further studies are recommended to investigate its potential effects on other cancer cell types</dc:description>
	<dc:publisher xml:lang="en">Universitas Hasanuddin</dc:publisher>
	<dc:date>2025-08-27</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jai2/article/view/46542</dc:identifier>
	<dc:identifier>10.70561/jal.v16i2.46542</dc:identifier>
	<dc:source xml:lang="en">Jurnal Ilmu Alam dan Lingkungan; Vol. 16 No. 2 (2025): Jurnal Ilmu Alam dan Lingkungan</dc:source>
	<dc:source>2549-8819</dc:source>
	<dc:source>2086-4604</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jai2/article/view/46542/13293</dc:relation>
</oai_dc:dc>