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Studi In Silico Senyawa Bioaktif Daun Sendok (Plantago Major) Sebagai Antidibetes

Indonesian Journal of Mathematics and Natural Sciences · Vol. 49 No. 1 (2026) · pp. 29–41

DOI
10.15294/jm.v49i1.22000
ISSN
2774-7832
Published
2026-10-05
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Diabetes Mellitus is a disease caused by decreased pancreatic function to produce insulin or insensitivity of insulin receptors. This research aims to analyse the bioactive compounds in spoon leaves as antidiabetics and the mechanism of action in silico. Bioactive compounds were collected using Dr. Duke's Phytochemical and Ethnobotanical Databases. Compound unification was done through PubChem. Way2Drug PASS Online was used to analyse biological activities related to antidiabetic. SEA and Swiss Target Prediction databases to determine the target protein. Molecular docking was performed using Pyrx application and visualized with Biovia Discovery Studio. A total of 8 spoon leaf bioactive compounds targets alpha glucosidase, alpha amylase, and GLP-1 proteins that regulate the occurrence of diabetes with a Pa>0.5 value. Based on the docking results luteolin, plantagoside, nepetin and scutellarin are alpha glucosidase inhibitors with binding affinity values of -7.5, -8.7, -8.2 and -8.3 kcal/mol. Catalpol and neochlorgenic acid are alpha amylase inhibitors with binding affinity of -7.1 and -7, 3 kcal/mol. Aucubin and fumaric acid are GLP-1 acceptors with binding affinity values of -7.3 and -4.6 kcal/mol. Visualization of docking that nepetin and neochlorgenic acid compounds, have similar interactions and amino acid residues with control drugs so that they can be used as antidiabetic drug candidates.

Keywords

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Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JM/oai, first harvested 5 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Studi In Silico Senyawa Bioaktif Daun Sendok (Plantago Major) Sebagai Antidibetes</dc:title>
	<dc:creator xml:lang="en">Susanti, R</dc:creator>
	<dc:creator xml:lang="en">Astuti , Dinar Diyah</dc:creator>
	<dc:subject xml:lang="en">Antidiabetic</dc:subject>
	<dc:subject xml:lang="en">in silico</dc:subject>
	<dc:subject xml:lang="en">Plantago major</dc:subject>
	<dc:subject xml:lang="en">bioactive compound </dc:subject>
	<dc:description xml:lang="en">Diabetes Mellitus is a disease caused by decreased pancreatic function to produce insulin or insensitivity of insulin receptors. This research aims to analyse the bioactive compounds in spoon leaves as antidiabetics and the mechanism of action in silico. Bioactive compounds were collected using Dr. Duke's Phytochemical and Ethnobotanical Databases. Compound unification was done through PubChem. Way2Drug PASS Online was used to analyse biological activities related to antidiabetic. SEA and Swiss Target Prediction databases to determine the target protein. Molecular docking was performed using Pyrx application and visualized with Biovia Discovery Studio. A total of 8 spoon leaf bioactive compounds targets alpha glucosidase, alpha amylase, and GLP-1 proteins that regulate the occurrence of diabetes with a Pa&amp;gt;0.5 value. Based on the docking results luteolin, plantagoside, nepetin and scutellarin are alpha glucosidase inhibitors with binding affinity values of -7.5, -8.7, -8.2 and -8.3 kcal/mol. Catalpol and neochlorgenic acid are alpha amylase inhibitors with binding affinity of -7.1 and -7, 3 kcal/mol. Aucubin and fumaric acid are GLP-1 acceptors with binding affinity values of -7.3 and -4.6 kcal/mol. Visualization of docking that nepetin and neochlorgenic acid compounds, have similar interactions and amino acid residues with control drugs so that they can be used as antidiabetic drug candidates.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2026-10-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JM/article/view/22000</dc:identifier>
	<dc:identifier>10.15294/jm.v49i1.22000</dc:identifier>
	<dc:source xml:lang="en">Indonesian Journal of Mathematics and Natural Sciences; Vol. 49 No. 1 (2026): Volume 49 Nomor 1 April 2026; 29-41</dc:source>
	<dc:source>2774-7832</dc:source>
	<dc:source>10.15294/jm.v49i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JM/article/view/22000/11663</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Indonesian Journal of Mathematics and Natural Sciences</dc:rights>
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