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Sunscreen Activity Test on Iler Leaf Ethanol Extract Cream (Coleus Scutellarioides (L) Benth) In Vivo

Journal of Science and Technology Research for Pharmacy · Vol. 3 No. 2 (2025) · pp. 28–37

DOI
10.15294/jstrp.v3i2.9665
ISSN
2776-0685
Published
2025-07-10
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Indonesia is one of the countries known as a tropical climate country with a high intensity of sun exposure. The sun's UV rays have health benefits. However, UV rays also have negative effects on skin health. Therefore, additional protection against solar UV rays is needed, namely by using sunscreen preparations derived from Iler Leaves (Coleus scutellarioides (L) Benth) which contain flavonoid and phenolic compounds. The purpose of this study was to determine the most optimal ethanol extract cream formula of iler leaf (Coleus scutellarioides (L) Benth) after preparation evaluation and determine the sunscreen activity of iler leaf ethanol extract cream (Coleus scutellarioides (L) Benth) in vivo. This research is a real pure experiment or also called True Experimental Research and uses The post test Only Control Group Design method. The results obtained from the evaluation of the ethanol extract of iler leaf cream preparation formula are with a cream formula consisting of 1.5% iler leaf extract, 18% stearic acid, 2% TEA, 2% cetyl alcohol, 8% glycerin, 0.2% metal paraben, 0.02% propyl paraben and aquadest. And after in vivo testing on white rats, it was found that the ethanol extract cream preparation of iler leaves had sunscreen activity as evidenced by the erythema effect that appeared after exposure under sunlight. So it can be concluded that the most optimum cream formula is a formula containing 18% stearic acid and 2% TEA. And the iler leaf ethanol extract cream has sunscreen activity after in vivo testing.

Keywords

Collaboration network of the authors

15 authors · 20 co-authorship links

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  • State University of Semarang
  • Affiliation unknown
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  • Same organisation
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Co-authorOrganisationJoint articles
AmeliyanaAffiliation unknown1
Prisma Detty NuryanaAffiliation unknown1
Nurul Fajar AgustinaAffiliation unknown1
Erika WuryaningsihAffiliation unknown1
Muhammad Shidqi Naufal AthallaAffiliation unknown1
Ernessa Indah Rotua SIRAITAffiliation unknown1
Rahma Annisa IzzaniaAffiliation unknown1
Sigit PriatmokoState University of Semarang1
Senda Kartika RakainsaAffiliation unknown1
Dhatu Sekar LarasatiAffiliation unknown1
Neli Syahida Ni’maAffiliation unknown1
Sitarina WidyariniAffiliation unknown1
Nanang FakhrudinAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JSTRP/oai, first harvested 5 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Sunscreen Activity Test on Iler Leaf Ethanol Extract Cream (Coleus Scutellarioides (L) Benth) In Vivo</dc:title>
	<dc:creator xml:lang="en">Zalzabila Adelya Putri, Zalza</dc:creator>
	<dc:creator xml:lang="en">Widhihastuti, Endah </dc:creator>
	<dc:subject xml:lang="en">Sunscreen</dc:subject>
	<dc:subject xml:lang="en"> in vivo</dc:subject>
	<dc:subject xml:lang="en">Iler leaf</dc:subject>
	<dc:subject xml:lang="en">Coleus scutellarioides (L) Benth</dc:subject>
	<dc:description xml:lang="en">Indonesia is one of the countries known as a tropical climate country with a high intensity of sun exposure. The sun's UV rays have health benefits. However, UV rays also have negative effects on skin health. Therefore, additional protection against solar UV rays is needed, namely by using sunscreen preparations derived from Iler Leaves (Coleus scutellarioides (L) Benth) which contain flavonoid and phenolic compounds. The purpose of this study was to determine the most optimal ethanol extract cream formula of iler leaf (Coleus scutellarioides (L) Benth) after preparation evaluation and determine the sunscreen activity of iler leaf ethanol extract cream (Coleus scutellarioides (L) Benth) in vivo. This research is a real pure experiment or also called True Experimental Research and uses The post test Only Control Group Design method. The results obtained from the evaluation of the ethanol extract of iler leaf cream preparation formula are with a cream formula consisting of 1.5% iler leaf extract, 18% stearic acid, 2% TEA, 2% cetyl alcohol, 8% glycerin, 0.2% metal paraben, 0.02% propyl paraben and aquadest. And after in vivo testing on white rats, it was found that the ethanol extract cream preparation of iler leaves had sunscreen activity as evidenced by the erythema effect that appeared after exposure under sunlight. So it can be concluded that the most optimum cream formula is a formula containing 18% stearic acid and 2% TEA. And the iler leaf ethanol extract cream has sunscreen activity after in vivo testing.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-07-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JSTRP/article/view/9665</dc:identifier>
	<dc:identifier>10.15294/jstrp.v3i2.9665</dc:identifier>
	<dc:source xml:lang="en">Journal of Science and Technology Research for Pharmacy; Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy; 28-37</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JSTRP/article/view/9665/4335</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>