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The Effect of Tamarind Fruit Nanoparticles (Tamarindus indica) on the Sperm Quality of Hyperglycemic Rats

Life Science · Vol. 14 No. 2 (2025) · pp. 69–77

DOI
10.15294/unnesjlifesci.v14.i2.24064
ISSN
2528-5009, 2252-6277
Published
2025-11-30
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Hyperglycemia is an increase in glucose levels in the blood. This condition can trigger glucose autooxidation which can produce free radicals. Free radicals can cause damage to male reproductive organs and quality. Tamarind fruit has a high flavonoid which has the potential as an antioxidant. This study aims to analyze the effect of tamarind fruit nanoparticles on spermatozoa quality in hyperglycemic rats. This study is experimental with Post-Test Control Group Design. A sample of 15 male Wistar rats were induced by alloxan and then divided into three groups, namely the control group, tamarind fruit nanoparticles with a dose of 30 mg/KgBB (NP1) and 60 mg/KgBB (NP2) for 28 days. Sperm quality was observed with parameters of concentration, motility and viability. The data were analyzed using One Way ANOVA and LSD. The results of the Anova test showed that tamarind nanoparticle treatment could significantly improve sperm quality (P<0.05). The LSD test showed that the concentration, motility and viability of sperm in group (K) were significantly different from groups NP1 and NP2. The highest to lowest average sperm concentration in sequence was in groups NP2 (49.60x106±6.06x106), NP1 (41.60x106±7.40x106) and K (20.80x106±7.56x106). The highest to lowest average percentage of sperm motility in sequence was in groups NP2 (82.20±9.75), NP1 (74.00±4.74), K (47.20±10.66). The highest to lowest average percentage of sperm viability in sequence was in the NP2 group (76.80±4.49), NP1 (72.20±7.12), K (31.60±7.89). The conclusion of this study is that tamarind nanoparticles have an effect on improving sperm quality in hyperglycemic rats.

Keywords

Collaboration network of the authors

40 authors · 85 co-authorship links · showing the 40 most connected

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  • State University of Semarang
  • Universitas Indraprasta PGRI
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Ari YuniastutiState University of Semarang9
Aditya MariantiAffiliation unknown6
Lisdiana LisdianaAffiliation unknown6
Didik Huswo UtomoAffiliation unknown3
Retno Sri IswariState University of Semarang2
LisdianaAffiliation unknown2
Siti Harnina BintariAffiliation unknown2
Kartika WidiyaningrumAffiliation unknown2
Endah PeniatiState University of Semarang2
Yanuarita TursinawatiAffiliation unknown1
Prima Gita IslamiAffiliation unknown1
Dinar Diyah AstutiAffiliation unknown1
Prima Gita Islami IslamiAffiliation unknown1
Eva Ulfiatus ShofiaAffiliation unknown1
Revinta Nur Aulia RochlyAffiliation unknown1
Anggun Try SetyaningsihAffiliation unknown1
Nana Kariada MartutiAffiliation unknown1
Retno PurwantiAffiliation unknown1
- UmarudinAffiliation unknown1
Arif HidayatAffiliation unknown1
Wiwi IsnaeniState University of Semarang1
Rheza Alfy YuliantoAffiliation unknown1
Priyantini WidiyaningrumAffiliation unknown1
Yuliana AstrianaAffiliation unknown1
SITI QOMARIAHAffiliation unknown1
Ning SetiatiAffiliation unknown1
Muhammad Rofiq NezarAffiliation unknown1
Margareta RahayuningsihAffiliation unknown1
Denny Herbianto BahtiarAffiliation unknown1
Fatchun NaimAffiliation unknown1
Risma Romaulina SimarmataAffiliation unknown1
Siti Rofiatus Sa’adahAffiliation unknown1
Sri UtamiUniversitas Indraprasta PGRI1
Yenni Tyas Wulandari K. EAffiliation unknown1
Isti FadahAffiliation unknown1
Addina Nur LuthfianiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/UnnesJLifeSci/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">The Effect of Tamarind Fruit Nanoparticles (Tamarindus indica) on the Sperm Quality of Hyperglycemic Rats</dc:title>
	<dc:creator xml:lang="en">Bagus Hammam Falah</dc:creator>
	<dc:creator xml:lang="en">Wulan Christijanti</dc:creator>
	<dc:creator xml:lang="en">Nugrahaningsih WH</dc:creator>
	<dc:creator xml:lang="en">R. Susanti</dc:creator>
	<dc:subject xml:lang="en">Hyperglicemia</dc:subject>
	<dc:subject xml:lang="en">Nanoparticles</dc:subject>
	<dc:subject xml:lang="en">Tamarind Fruit</dc:subject>
	<dc:subject xml:lang="en">Sperm Quality</dc:subject>
	<dc:description xml:lang="en">Hyperglycemia is an increase in glucose levels in the blood. This condition can trigger glucose autooxidation which can produce free radicals. Free radicals can cause damage to male reproductive organs and quality. Tamarind fruit has a high flavonoid which has the potential as an antioxidant. This study aims to analyze the effect of tamarind fruit nanoparticles on spermatozoa quality in hyperglycemic rats. This study is experimental with Post-Test Control Group Design. A sample of 15 male Wistar rats were induced by alloxan and then divided into three groups, namely the control group, tamarind fruit nanoparticles with a dose of 30 mg/KgBB (NP1) and 60 mg/KgBB (NP2) for 28 days. Sperm quality was observed with parameters of concentration, motility and viability. The data were analyzed using One Way ANOVA and LSD. The results of the Anova test showed that tamarind nanoparticle treatment could significantly improve sperm quality (P&amp;lt;0.05). The LSD test showed that the concentration, motility and viability of sperm in group (K) were significantly different from groups NP1 and NP2. The highest to lowest average sperm concentration in sequence was in groups NP2 (49.60x106±6.06x106), NP1 (41.60x106±7.40x106) and K (20.80x106±7.56x106). The highest to lowest average percentage of sperm motility in sequence was in groups NP2 (82.20±9.75), NP1 (74.00±4.74), K (47.20±10.66). The highest to lowest average percentage of sperm viability in sequence was in the NP2 group (76.80±4.49), NP1 (72.20±7.12), K (31.60±7.89). The conclusion of this study is that tamarind nanoparticles have an effect on improving sperm quality in hyperglycemic rats.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/UnnesJLifeSci/article/view/24064</dc:identifier>
	<dc:identifier>10.15294/unnesjlifesci.v14.i2.24064</dc:identifier>
	<dc:source xml:lang="en">Life Science; Vol. 14 No. 2 (2025): November 2025; 69-77</dc:source>
	<dc:source>2528-5009</dc:source>
	<dc:source>2252-6277</dc:source>
	<dc:source>10.15294/unnesjlifesci.v14.i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/UnnesJLifeSci/article/view/24064/7280</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Life Science</dc:rights>
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