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Topical Ointment Anredera cordifolia Leaves Ethanolic Extract-Loaded Nanochitosan Promotes Wound Healing in Hyperglycemic Rat

Biosaintifika: Journal of Biology & Biology Education · Vol. 16 No. 1 (2024) · pp. 155–165

DOI
10.15294/biosaintifika.v15i1.1842
ISSN
2338-7610, 2085-191X
Published
2024-04-20
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Wound healing in hyperglycemia patients is still a challenge in the medical field. Bioactive compounds of binahong leaf extract can support the wound healing process. Nanoencapsulation of the extract can avoid oxidation and optimize drug delivery to target tissues. This study aimed to analyze the effect of nanochitosan encapsulated binahong extract ointment (NEBE/Oint) on the percentage of wound healing, angiogenesis, collagen density, and epithelial thickness in hyperglycemic rats. This study used 80 mg/kg streptozotocin-induced hyperglycemia rats injured in the back area. Rats were divided into P0 (0,9% NaCl), P1 (10% povidone-iodine ointment (PI/Oint)), P2 (10% NEBE/Oint), P3 (20% NEBE/Oint), P4 (30% NEBE/Oint). Phytochemical screening of binahong leaves extract showed positive results for flavonoids, alkaloids, saponins, and tannins. NEBE particle size was 169 nm with a size distribution of 0.2 and a zeta potential value of -40,2 mV. The results showed NEBE ointment had a significant effect when compared with negative control on wound healing hyperglycemic rats. The conclusion is that nanochitosan drug delivery has the potential as an alternative wound treatment. The novelty of this study is the use of nanochitosan to accelerate wound healing in hyperglycemic rats. The results of this study are expected to become a reference for new wound-healing methods in the medical field.

Keywords

Collaboration network of the authors

40 authors · 131 co-authorship links · showing the 40 most connected

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  • State University of Semarang
  • Affiliation unknown
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  • Same organisation
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Kustopo BudiraharjoAffiliation unknown5
Dwinanda BudiwardaniAffiliation unknown3
Susilo SusiloAffiliation unknown2
Ian YuliantiAffiliation unknown2
Cinta Etna SyakeraAffiliation unknown2
Laode ErmanjayaAffiliation unknown2
Maisya Sifana MauraAffiliation unknown2
Muhammad Anwar DjaelaniAffiliation unknown2
Langlang HandayaniAffiliation unknown1
Teguh DarsonoAffiliation unknown1
Slamet HaryonoAffiliation unknown1
Usrek Tani UtinaAffiliation unknown1
Haydnn Caesha MaulanaAffiliation unknown1
Musa Abdul HalimAffiliation unknown1
Iklas Adi PangestuAffiliation unknown1
Nabila Rakha PutriAffiliation unknown1
Masturi MasturiState University of Semarang1
Yohannes SardjonoAffiliation unknown1
Rio Agustian Gilang FernandoAffiliation unknown1
Pratiwi DwijanantiAffiliation unknown1
Ani RusilowatiState University of Semarang1
Amelia CristinaAffiliation unknown1
Hartono HartonoAffiliation unknown1
Agnes Yustika Wulan ArumAffiliation unknown1
Ekberd KreyAffiliation unknown1
Siti HananAffiliation unknown1
Natalia Putri Eko WibowoAffiliation unknown1
Rosyida MukarromahAffiliation unknown1
Tatag Yufitra RusAffiliation unknown1
Gozali GozaliAffiliation unknown1
Bambang Jati KusumaAffiliation unknown1
Sara WibawaningAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Topical Ointment Anredera cordifolia Leaves Ethanolic Extract-Loaded Nanochitosan Promotes Wound Healing in Hyperglycemic Rat</dc:title>
	<dc:creator xml:lang="en">Alfatinnisa, Zalfa </dc:creator>
	<dc:creator xml:lang="en">Andriyan, Mohammad Wahyu </dc:creator>
	<dc:creator xml:lang="en">Saputra, Muhammad Ragil </dc:creator>
	<dc:creator xml:lang="en">Astuti, Endah Puji </dc:creator>
	<dc:creator xml:lang="en">Sunarno, Sunarno</dc:creator>
	<dc:creator xml:lang="en">Isdadiyanto, Sri </dc:creator>
	<dc:creator xml:lang="en">Subagio, Agus </dc:creator>
	<dc:creator xml:lang="en">Jaya, La Ode Irman </dc:creator>
	<dc:subject xml:lang="en">binahong (Anredera cordifolia), hyperglycemia, nanoencapsulation, wound healing</dc:subject>
	<dc:description xml:lang="en">Wound healing in hyperglycemia patients is still a challenge in the medical field. Bioactive compounds of binahong leaf extract can support the wound healing process. Nanoencapsulation of the extract can avoid oxidation and optimize drug delivery to target tissues. This study aimed to analyze the effect of nanochitosan encapsulated binahong extract ointment (NEBE/Oint) on the percentage of wound healing, angiogenesis, collagen density, and epithelial thickness in hyperglycemic rats. This study used 80 mg/kg streptozotocin-induced hyperglycemia rats injured in the back area. Rats were divided into P0 (0,9% NaCl), P1 (10% povidone-iodine ointment (PI/Oint)), P2 (10% NEBE/Oint), P3 (20% NEBE/Oint), P4 (30% NEBE/Oint). Phytochemical screening of binahong leaves extract showed positive results for flavonoids, alkaloids, saponins, and tannins. NEBE particle size was 169 nm with a size distribution of 0.2 and a zeta potential value of -40,2 mV. The results showed NEBE ointment had a significant effect when compared with negative control on wound healing hyperglycemic rats. The conclusion is that nanochitosan drug delivery has the potential as an alternative wound treatment. The novelty of this study is the use of nanochitosan to accelerate wound healing in hyperglycemic rats. The results of this study are expected to become a reference for new wound-healing methods in the medical field.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2024-04-20</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/1842</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v15i1.1842</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 16 No. 1 (2024): April 2024; 155-165</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v16i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/1842/177</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>