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Antihyperlipidemic Activity of Tamarind (Tamarindus indica) Extract on the Lipid Profile of Albino Rats

Biosaintifika: Journal of Biology & Biology Education · Vol. 16 No. 1 (2024) · pp. 191–197

DOI
10.15294/biosaintifika.v15i1.7579
ISSN
2338-7610, 2085-191X
Published
2024-04-20
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Tamarind are widely used as antioxidants, anti-diabetes, anti-hyperlipidemia, and anti-cholesterolemia. The aim of this research is to analyze the anti-hyperlipidemic activity of extracts of tamarind fruit pulp, seeds and leaves on the lipid profile of rats. Experimental research was designed with 20 male rats divided Control (C), Tamarind leaves (TL), Tamarind fruit pulp (TF), and Tamarind seeds (TS) extracts, each 500 mg/kg of body weight. All of the groups were given standard feed and induced with lard at 3 ml/rat/day for 14 days. On day 15, the rats were continued to be induced with lard and were given extracts according to each group for 2 weeks. The data obtained such as rats’ body weight, level of cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), triglycerides (TG) and Malondialdehyde (MDA) were analyzed using anova (P<0.05) and the Duncan Multiple Range Test (DMRT). The results showed that each extract had a significant effect on cholesterol, HDL and MDA levels but not on body weight, LDL and triglycerides. Levels of MDA in the group with the extract were significantly lower than the control. Tamarind pulp, seeds and leaf extracts show antihyperlipidemic activity by reducing cholesterol and HDL levels. This can be the basis for using parts of the tamarind plant as a supplement for the community to maintain fat levels.

Keywords

Collaboration network of the authors

40 authors · 100 co-authorship links · showing the 40 most connected

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  • State University of Semarang
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Aditya MariantiAffiliation unknown9
Ari YuniastutiState University of Semarang8
Retno Sri IswariState University of Semarang6
Lisdiana LisdianaAffiliation unknown4
Siti Harnina BintariAffiliation unknown3
LisdianaAffiliation unknown3
Nugrahaningsih WHAffiliation unknown3
Wiwi IsnaeniState University of Semarang3
Priyantini WidiyaningrumAffiliation unknown2
Ani RusilowatiState University of Semarang2
Didik Huswo UtomoAffiliation unknown2
Enni Suwarsi RahayuState University of Semarang2
Lili Astuti IsnaeniAffiliation unknown2
Kartika WidiyaningrumAffiliation unknown2
Bagus Hammam FalahAffiliation unknown2
Pramesti DewiAffiliation unknown2
Yanuarita TursinawatiAffiliation unknown1
Prima Gita IslamiAffiliation unknown1
Dinar Diyah AstutiAffiliation unknown1
Prima Gita Islami IslamiAffiliation unknown1
K Syifa FauziyahAffiliation unknown1
Tristania Magdalena DumatubunAffiliation unknown1
Thianika Shalsabillah ArmandokoAffiliation unknown1
Eva Ulfiatus ShofiaAffiliation unknown1
Nabila Meilani DewiAffiliation unknown1
Arneta EvaniaAffiliation unknown1
Anggun Try SetyaningsihAffiliation unknown1
Nana Kariada MartutiAffiliation unknown1
Retno PurwantiAffiliation unknown1
- UmarudinAffiliation unknown1
Arif HidayatAffiliation unknown1
Rheza Alfy YuliantoAffiliation unknown1
Yuliana AstrianaAffiliation unknown1
SITI QOMARIAHAffiliation unknown1
Muhammad Rofiq NezarAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Antihyperlipidemic Activity of Tamarind (Tamarindus indica) Extract on the Lipid Profile of Albino Rats</dc:title>
	<dc:creator xml:lang="en">Christijanti, Wulan </dc:creator>
	<dc:creator xml:lang="en">Susanti, R. </dc:creator>
	<dc:creator xml:lang="en">Rakainsa, Senda Kartika </dc:creator>
	<dc:creator xml:lang="en">Widyaningrum, Kartika </dc:creator>
	<dc:creator xml:lang="en">Mohamed, Mohd Salim Bin </dc:creator>
	<dc:subject xml:lang="en">anti-hyperlipidemia; lipid profile; malondialdehyde; tamarind</dc:subject>
	<dc:description xml:lang="en">Tamarind are widely used as antioxidants, anti-diabetes, anti-hyperlipidemia, and anti-cholesterolemia. The aim of this research is to analyze the anti-hyperlipidemic activity of extracts of tamarind fruit pulp, seeds and leaves on the lipid profile of rats.
Experimental research was designed with 20 male rats divided   Control (C), Tamarind leaves (TL), Tamarind fruit pulp (TF), and Tamarind seeds (TS) extracts, each 500 mg/kg of body weight. All of the groups were given standard feed and induced with lard at 3 ml/rat/day for 14 days. On day 15, the rats were continued to be induced with lard and were given extracts according to each group for 2 weeks. The data obtained such as rats’ body weight, level of cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), triglycerides (TG) and Malondialdehyde (MDA)  were analyzed using anova (P&amp;lt;0.05) and the Duncan Multiple Range Test (DMRT). The results showed that each extract had a significant effect on cholesterol, HDL and MDA levels but not on body weight, LDL and triglycerides. Levels of MDA in the group with the extract were significantly lower than the control. Tamarind pulp, seeds and leaf extracts show antihyperlipidemic activity by reducing cholesterol and HDL levels.
This can be the basis for using parts of the tamarind plant as a supplement for the community to maintain fat levels.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2024-04-20</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/7579</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v15i1.7579</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 16 No. 1 (2024): April 2024; 191-197</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v16i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/7579/850</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>