Journal
Mosaic of Drosophila Behavior Due to Bisphenol-A Exposure: From Hyperactivity to Aversion
Biosaintifika: Journal of Biology & Biology Education · Vol. 17 No. 3 (2025) · pp. 488–501
- ISSN
- 2338-7610, 2085-191X
- Published
- 2025-11-18
- Publisher
- Universitas Negeri Semarang
- Language
- eng
Abstract
Bisphenol-A (BPA) is classified as an endocrine-disrupting chemical that is widely found in everyday food. However, various studies have reported inconsistent results regarding the effects of this exposure on behavior. This study aimed to evaluate how dose, genetic background, and duration of exposure interact to shape behavioral responses in Drosophila melanogaster exposed to BPA. Three strains (Wild-type, white-eye, and black-body) were cultured on a medium containing 0, 0.25, and 0.5 mg/mL BPA for two generations. Before exposure (G0), after the first generation of exposure (G1), and after the second generation of exposure (G2), three behaviors were measured: larval crawling speed, number of larval contractions, and larval exploration distance. Repeated-measures ANOVA revealed a non-monotonic pattern in behavioral responses. Each behavior exhibited distinct sensitivities to treatment factors, and complex interactions were observed between genetic factors, dose, and time (generation). Furthermore, the effects of BPA are not general but rather specific to the type of behavior observed. Generational effects are evident in some behavioral data. In addition, fly strain plays a role in determining the effect of exposure on behavioral responses.
Keywords
Collaboration network of the authors
40 authors · 114 co-authorship links · 20 across different organisations · showing the 40 most connected
Hover or tap a name to highlight its co-authors. Double-click to open the author's page.
- State University of Malang
- University of Mataram
- Universiti Brunei Darussalam
- Universitas Islam Negeri Maulana Malik Ibrahim
- Fiji National University
- Yogyakarta State University
- Universitas Muslim Buton
- Other organisations
- Affiliation unknown
- Different organisations
- Same organisation
- Affiliation unknown
- Thicker line = more joint articles · bigger circle = more articles
Show as table
| Co-author | Organisation | Joint articles |
|---|---|---|
| Asep Bayu Dani Nandiyanto | Affiliation unknown | 3 |
| Susriyati Mahanal | State University of Malang | 2 |
| Risti Ragadhita | Affiliation unknown | 2 |
| Muhammad Asy’ari | University of Mataram | 2 |
| Agus Mukti Wibowo | State University of Malang | 1 |
| Sugeng Utaya | State University of Malang | 1 |
| W. Wahjoedi | State University of Malang | 1 |
| Saiful Amin | Universitas Islam Negeri Maulana Malik Ibrahim | 1 |
| Ravinesh Rohit Prasad | Fiji National University | 1 |
| Herdiyana Fitriani | University of Mataram | 1 |
| İnsih Wilujeng | Yogyakarta State University | 1 |
| Ni Nyoman Sri Putu Verawati | University of Mataram | 1 |
| Saiful Prayogi | Affiliation unknown | 1 |
| Hikmawati Hikmawati | Universitas Muslim Buton | 1 |
| Dwi candra setiawan | Affiliation unknown | 1 |
| A D Corebima | Affiliation unknown | 1 |
| Ibrahim Bafadal | Affiliation unknown | 1 |
| Achmad Supriyanto | Affiliation unknown | 1 |
| Syamsul Hadi | Affiliation unknown | 1 |
| Sudaryono Sudaryono | Affiliation unknown | 1 |
| Mujiyono Wiryotinoyo | Affiliation unknown | 1 |
| Syarifatul Mubarak | Universitas Islam Negeri Mataram | 1 |
| Mujakir Mujakir | Affiliation unknown | 1 |
| Alfina Mizriaty | Affiliation unknown | 1 |
| Erna Piantari | Indonesia University of Education | 1 |
| Aisha Nadhira Syazwany | Affiliation unknown | 1 |
| Karina Nur Syarafah | Affiliation unknown | 1 |
| Themy Sabri Syuhada | Affiliation unknown | 1 |
| Obie Farobie | Affiliation unknown | 1 |
| Joni Sitorus | Affiliation unknown | 1 |
| Paramitha Cahyani | Affiliation unknown | 1 |
Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.