Comparison of the Subchronic Anti-Inflammatory Activity of the Ethanol and Ethyl Acetate Extracts of Breadfruit Leaves (Artocarpus altilis) on CFA-Induced Mice

Widhihastuti, Endah; Ni'ma, Neli Syahida; Widyarini, Sitarina; Fakhrudin, Nanang

doi:10.15294/ijcs.v10i1.46870

Journal

Comparison of the Subchronic Anti-Inflammatory Activity of the Ethanol and Ethyl Acetate Extracts of Breadfruit Leaves (Artocarpus altilis) on CFA-Induced Mice

Indonesian Journal of Chemical Science · Vol. 10 No. 1 (2021) · pp. 35–40

DOI: 10.15294/ijcs.v10i1.46870
ISSN: 2502-6844, 2252-6951
Published: 2021-05-17
Publisher: Universitas Negeri Semarang
Language: eng

Abstract

Chronic inflammation of the joints can cause rheumatoid arthritis (RA). Breadfruit (Artocarpus altilis) is known to have anti-inflammatory activity. Previous studies showed that ethanol and ethyl acetate extracts of breadfruit leaves have anti-inflammatory activity in an acute anti-inflammatory model. This study aimed to determine the sub chronic anti-inflammatory activity of the ethanol and ethyl acetate extracts in CFA-induced mice. Balp/c mice (15) were divided into 5 groups: normal group, solvent-treated group, diclofenac sodium-treated group (dose 3 mg/kgBW), ethyl acetate extract-treated group (500 mg/kgBW dose), and ethanol extract-treated group (500 mg/kgBW dose). The extracts were given orally every day for 28 days. The body weight and edema volume were measured on the day of 1, 7, 14, 21, and 28 after CFA induction. This study showed that the ethanol and ethyl acetate extracts were able to inhibit inflammatory process by reducing the edema in mice. Ethyl acetate extract exhibited a stronger anti-inflammatory activity compared to the ethanol extract. Although the body weight of the mice treated with the ethanol extract was higher than that of the ethyl acetate extract, both extracts did not cause a significant change in body weight compared to the normal group. The results of this study indicated that the ethanol and ethyl acetate extracts of breadfruit leaves both demonstrated a sub chronic anti-inflammatory activity in mice.

Collaboration network of the authors

23 authors · 35 co-authorship links

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State University of Semarang
Affiliation unknown

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Co-author	Organisation	Joint articles
Muhammad Athfal Nuransyah	Affiliation unknown	1
Zalza Zalzabila Adelya Putri	Affiliation unknown	1
Ameliyana	Affiliation unknown	1
Prisma Detty Nuryana	Affiliation unknown	1
Nurul Fajar Agustina	Affiliation unknown	1
Erika Wuryaningsih	Affiliation unknown	1
Dzulrifaad Ubaidillah Al Afza	Affiliation unknown	1
Muhammad Shidqi Naufal Athalla	Affiliation unknown	1
Ernessa Indah Rotua SIRAIT	Affiliation unknown	1
Annisa Aulia Savitri	Affiliation unknown	1
Willy Tirza Eden	Affiliation unknown	1
Samuel Budi Wardhana Kusuma	Affiliation unknown	1
Rahma Annisa Izzania	Affiliation unknown	1
Sigit Priatmoko	State University of Semarang	1
Senda Kartika Rakainsa	Affiliation unknown	1
Dhatu Sekar Larasati	Affiliation unknown	1
Nanik Wijayati	State University of Semarang	1
Sudarmin	State University of Semarang	1
Sri Anggini Wahyuningsih	Affiliation unknown	1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/ijcs/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.

Original metadata (oai_dc)

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	<dc:title xml:lang="en-US">Comparison of the Subchronic Anti-Inflammatory Activity of the Ethanol and Ethyl Acetate Extracts of Breadfruit Leaves (Artocarpus altilis) on CFA-Induced Mice</dc:title>
	<dc:creator>Widhihastuti, Endah</dc:creator>
	<dc:creator>Ni'ma, Neli Syahida</dc:creator>
	<dc:creator>Widyarini, Sitarina</dc:creator>
	<dc:creator>Fakhrudin, Nanang</dc:creator>
	<dc:description xml:lang="en-US">Chronic inflammation of the joints can cause rheumatoid arthritis (RA). Breadfruit (Artocarpus altilis) is known to have anti-inflammatory activity. Previous studies showed that ethanol and ethyl acetate extracts of breadfruit leaves have anti-inflammatory activity in an acute anti-inflammatory model. This study aimed to determine the sub chronic anti-inflammatory activity of the ethanol and ethyl acetate extracts in CFA-induced mice. Balp/c mice (15) were divided into 5 groups: normal group, solvent-treated group, diclofenac sodium-treated group (dose 3 mg/kgBW), ethyl acetate extract-treated group (500 mg/kgBW dose), and ethanol extract-treated group (500 mg/kgBW dose). The extracts were given orally every day for 28 days. The body weight and edema volume were measured on the day of 1, 7, 14, 21, and 28 after CFA induction. This study showed that the ethanol and ethyl acetate extracts were able to inhibit inflammatory process by reducing the edema in mice. Ethyl acetate extract exhibited a stronger anti-inflammatory activity compared to the ethanol extract. Although the body weight of the mice treated with the ethanol extract was higher than that of the ethyl acetate extract, both extracts did not cause a significant change in body weight compared to the normal group. The results of this study indicated that the ethanol and ethyl acetate extracts of breadfruit leaves both demonstrated a sub chronic anti-inflammatory activity in mice.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2021-05-17</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/ijcs/article/view/46870</dc:identifier>
	<dc:identifier>10.15294/ijcs.v10i1.46870</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Chemical Science; Vol 10 No 1 (2021); 35-40</dc:source>
	<dc:source>2502-6844</dc:source>
	<dc:source>2252-6951</dc:source>
	<dc:source>10.15294/ijcs.v10i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/ijcs/article/view/46870/19885</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Indonesian Journal of Chemical Science</dc:rights>
</oai_dc:dc>