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Effectiveness of Soursop Leaf Extract (Annona muricata l.) on IL-6 Levels in Mammary Sprague dawley Female Rats Induced by Staphylococcus aureus

Unnes Journal of Public Health · Vol. 9 No. 1 (2020) · pp. 56–63

DOI
10.15294/ujph.v9i1.30904
ISSN
2548-7604, 2252-6781
Published
2020-01-31
Publisher
Universitas Negeri Semarang (UNNES) in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))
Language
eng

Abstract

Staphylococcus aureus is a Gram-positive bacterium that causes inflammation such as mastitis in the breast. Breast mastitis can occur in nursing mothers and requires first aid or initial treatment. Herbal ingredients can be utilized because they are easily obtained and can be prepared by the community themselves. The study aimed to analyze the effectiveness of soursop leaf extract on IL-6 levels in mammae of female rats Sprague dawley induced by S. aureus. The study was divided into four groups consisting of five rats that were induced by S. aureus 2 x 107 CFU/ml. Group I was given 0.5% Na.CMC, Group II gave 45 mg/kgBW cefadroxil antibiotics, group III administered 100 mg / kgBW soursop leaf extract, and group IV administered soursop leaf extract combined with cefadroxil. Each group was given treatment twice a day for 5 days. IL-6 levels were measured on days 3 and 6. The results of this study showed IL-6 levels in group III were 7.50 ± 1.74 pg/ml on the 3rd day, and 4.51 ± 1.47 pg/ml on the 6th day. The results showed there were differences in IL-6 levels in group III (p = 0.037). Soursop leaf extract can be used as a therapy for mastitis caused by S. aureus.

Collaboration network of the authors

17 authors · 45 co-authorship links

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  • Institut Agama Islam Negeri Kendari
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Yusnita RifaiAffiliation unknown2
Asnah MarzukiAffiliation unknown2
Syaharuddin KasimAffiliation unknown2
Endhah YulyartiAffiliation unknown1
Ana AdriyaniAffiliation unknown1
Yulia Yusrini DjabirAffiliation unknown1
Elly WahyudinAffiliation unknown1
Latifah RahmanAffiliation unknown1
Suryanita SuryanitaAffiliation unknown1
Aliyah AliyahAffiliation unknown1
Herlina RanteAffiliation unknown1
Damaiyanti DamaiyantiAffiliation unknown1
Nurjannah NurjannahInstitut Agama Islam Negeri Kendari1
Nana Juniarti Natsir DjideAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/ujph/oai, first harvested 6 Nov 2026, last seen 6 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Effectiveness of Soursop Leaf Extract (Annona muricata l.) on IL-6 Levels in Mammary Sprague dawley Female Rats Induced by Staphylococcus aureus</dc:title>
	<dc:creator>Purnamasari, Feby</dc:creator>
	<dc:creator>Yulianty, Risfah</dc:creator>
	<dc:creator>Latief, Syamsa</dc:creator>
	<dc:description xml:lang="en-US">Staphylococcus aureus is a Gram-positive bacterium that causes inflammation such as mastitis in the breast. Breast mastitis can occur in nursing mothers and requires first aid or initial treatment. Herbal ingredients can be utilized because they are easily obtained and can be prepared by the community themselves. The study aimed to analyze the effectiveness of soursop leaf extract on IL-6 levels in mammae of female rats Sprague dawley induced by S. aureus. The study was divided into four groups consisting of five rats that were induced by S. aureus 2 x 107 CFU/ml. Group I was given 0.5% Na.CMC, Group II gave 45 mg/kgBW cefadroxil antibiotics, group III administered 100 mg / kgBW soursop leaf extract, and group IV administered soursop leaf extract combined with cefadroxil. Each group was given treatment twice a day for 5 days. IL-6 levels were measured on days 3 and 6. The results of this study showed IL-6 levels in group III were 7.50 ± 1.74 pg/ml on the 3rd day, and 4.51 ± 1.47 pg/ml on the 6th day. The results showed there were differences in IL-6 levels in group III (p = 0.037). Soursop leaf extract can be used as a therapy for mastitis caused by S. aureus.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang (UNNES) in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))</dc:publisher>
	<dc:date>2020-01-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/ujph/article/view/30904</dc:identifier>
	<dc:identifier>10.15294/ujph.v9i1.30904</dc:identifier>
	<dc:source xml:lang="en-US">Unnes Journal of Public Health; Vol 9 No 1 (2020): Unnes Journal of Public Health; 56-63</dc:source>
	<dc:source>2548-7604</dc:source>
	<dc:source>2252-6781</dc:source>
	<dc:source>10.15294/ujph.v9i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/ujph/article/view/30904/15441</dc:relation>
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