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Antioxidant activity potential of 96% ethanol extract from jackfruit (Artocarpus integer) peel based on IC50 value

Proceedings Academic Universitas Jambi · Vol. 1 No. 2 (2025) · pp. 722–727

DOI
10.22437/proca.v1i2.50328
Published
2025-11-30
Publisher
LPPM Universitas Jambi
Language
en
License
creativecommons.org/licenses/by/4.0

Abstract

Background: Jackfruit (Artocarpus integer) peel is an agricultural waste with potential as a source of bioactive compounds. Objective: This study aims to evaluate the potential antioxidant activity of cempedak fruit peel extract using a 96% ethanol solvent. The extract, tested as fraction F3P, is believed to contain phenolic and flavonoid compounds that act as free radical scavengers. Extraction was performed using the maceration method. Methods: Antioxidant activity was tested in vitro using the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging method at various concentrations, ranging from 20 ppm to 100 ppm. Based on the percentage inhibition data obtained, the IC50 (Inhibitory Concentration 50%) value was calculated through logarithmic/linear regression analysis. Results: The calculation results show that the 96% ethanol extract of cempedak fruit peel (fraction F3P) has an IC50 value of 8.872 ppm. This IC50 value, which is below 50 ppm, indicates that the extract has very strong antioxidant activity. The active compounds within it can reduce 50% of DPPH free radicals at very low concentrations. Conclusion: This study concludes that the 96% ethanol extract of cempedak fruit peel is a highly potent and valuable source of natural antioxidants. Utilizing jackfruit peel waste can be a solution for developing functional food products or health supplements.

Keywords

Collaboration network of the authors

40 authors · 279 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Universitas Jambi
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Zahra Frizki AstyAffiliation unknown11
Annissa DelfiraAffiliation unknown9
Mara Imam Taufiq SiregarAffiliation unknown9
Mirna Marhami IskandarAffiliation unknown9
Tengku Arief Buana PerkasaAffiliation unknown5
Patrick Wiliam GadingAffiliation unknown5
HaninaAffiliation unknown5
Rita HalimAffiliation unknown5
Budi JustitiaAffiliation unknown5
Fairuz FairuzAffiliation unknown4
Lipinwati LipinwatiAffiliation unknown4
Zilzikridini WijayantiAffiliation unknown4
Huntari HarahapAffiliation unknown4
Rina Nofri EnisAffiliation unknown4
Attiya IstariniAffiliation unknown4
Armaidi DarmawanAffiliation unknown4
Erny KusdiyahAffiliation unknown4
Raihanah SuzanAffiliation unknown4
Afifah AmatullahAffiliation unknown3
Tia Wida EkaputriAffiliation unknown3
Hanina HaninaAffiliation unknown3
Putri Sari WulandariAffiliation unknown3
Wahyu Indah Dewi AuroraAffiliation unknown3
Nuriyah NuriyahAffiliation unknown2
Anggelia PuspasariAffiliation unknown2
Citra MaharaniAffiliation unknown2
FairuzAffiliation unknown2
FitriyantiAffiliation unknown2
Muhammad SyukriUniversitas Halu Oleo2
Herlambang HerlambangUniversitas Jambi2
Ave Olivia RahmanAffiliation unknown2
Agung Kurnia YahyaAffiliation unknown1
Apsari Puspita AiniAffiliation unknown1
Anang Baharuddin SahaqAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/PROCA/oai, first harvested 6 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Antioxidant activity potential of 96% ethanol extract from jackfruit (Artocarpus integer) peel based on IC50 value</dc:title>
	<dc:creator xml:lang="en">Ayudia, Esa Indah</dc:creator>
	<dc:creator xml:lang="en">Miftahurrahmah</dc:creator>
	<dc:creator xml:lang="en">Lipinwati</dc:creator>
	<dc:creator xml:lang="en">Dewi, Hasna</dc:creator>
	<dc:creator xml:lang="en">Hafizah</dc:creator>
	<dc:creator xml:lang="en">Denok Tri Hardiningsih</dc:creator>
	<dc:subject xml:lang="en">Jackfruit Peel; 96% Ethanol; DPPH, Antioxidant; IC50; Artocarpus integer</dc:subject>
	<dc:description xml:lang="en">Background: Jackfruit (Artocarpus integer) peel is an agricultural waste with potential as a source of bioactive compounds. Objective: This study aims to evaluate the potential antioxidant activity of cempedak fruit peel extract using a 96% ethanol solvent. The extract, tested as fraction F3P, is believed to contain phenolic and flavonoid compounds that act as free radical scavengers. Extraction was performed using the maceration method. Methods: Antioxidant activity was tested in vitro using the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging method at various concentrations, ranging from 20 ppm to 100 ppm. Based on the percentage inhibition data obtained, the IC50 (Inhibitory Concentration 50%) value was calculated through logarithmic/linear regression analysis. Results: The calculation results show that the 96% ethanol extract of cempedak fruit peel (fraction F3P) has an IC50 value of 8.872 ppm. This IC50 value, which is below 50 ppm, indicates that the extract has very strong antioxidant activity. The active compounds within it can reduce 50% of DPPH free radicals at very low concentrations. Conclusion: This study concludes that the 96% ethanol extract of cempedak fruit peel is a highly potent and valuable source of natural antioxidants. Utilizing jackfruit peel waste can be a solution for developing functional food products or health supplements.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/PROCA/article/view/50328</dc:identifier>
	<dc:identifier>10.22437/proca.v1i2.50328</dc:identifier>
	<dc:source xml:lang="en">Proceedings Academic Universitas Jambi; Vol. 1 No. 2 (2025): The 6th Jambi Medicine and Health Science International Conference (JAMHESIC); 722-727</dc:source>
	<dc:source>10.22437/proca.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/PROCA/article/view/50328/22662</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Esa Indah Ayudia, Miftahurrahmah, Lipinwati, Hasna Dewi, Hafizah, Denok Tri Hardiningsih</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>