Melola Discovery

← Melola Discovery

Open access Journal

Evaluation of the antidiabetic activity of ethyl acetate partition of ekor naga leaves (Rhaphidophora pinnata (L.f) Schott) on male white mice induced by alloxan

Proceedings Academic Universitas Jambi · Vol. 1 No. 2 (2025) · pp. 929–934

DOI
10.22437/proca.v1i2.50511
Published
2025-11-30
Publisher
LPPM Universitas Jambi
Language
en
License
creativecommons.org/licenses/by/4.0

Abstract

Background: Diabetes mellitus is a condition where blood glucose levels increase due to a decrease in the amount or sensitivity of insulin produced by the body. Previous research has shown that the ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f.) Schott) has potential as an antidiabetic agent. The extract also contains several secondary metabolic compounds such as flavonoids and phenolics, which are suspected to have antidiabetic potential. Objective: This research aims to investigate the activity of ethyl acetate partitioning of Ekor Naga leaves extract (Rhaphidophora pinnata (L.f.) Schott) in reducing blood sugar levels in diabetic mice. Methods: This research employed a Completely Randomized Design (CRD) method with six treatments: a normal control, a glibenclamide positive control, a Na-CMC negative control, and treatment groups with doses of 125, 250, and 500 mg/kg body weight (BW) of the ethyl acetate partition of ekor naga leaves extract. The observed parameter was the average decrease in blood sugar levels over a 21-day period.Results: The results were analyzed using the one-way ANOVA test, followed by Duncan's multiple range test. The research showed that the ethyl acetate partition of Ekor Naga leaves can reduce blood sugar levels in mice over 21 days. The results have shown significant improvement in blood sugar levels between treatment groups. The best dose in reducing blood glucose levels was 500 mg/KgBW with a percentage decrease of 58.98%.Conclusion: Ethyl acetate partition of ekor naga leaves has potential as an antidiabetic agent.

Keywords

Collaboration network of the authors

40 authors · 224 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
FitrianingsihAffiliation unknown10
SyamsurizalAffiliation unknown8
Rina Nofri EnisAffiliation unknown7
Anggelia PuspasariAffiliation unknown6
Citra MaharaniAffiliation unknown6
Elisma .Affiliation unknown6
Puspa Dwi PratiwiAffiliation unknown5
Wahyu Indah Dewi AuroraAffiliation unknown4
Uce LestariAffiliation unknown4
Susan TarawifaAffiliation unknown4
Diah Tri UtamiAffiliation unknown4
FairuzAffiliation unknown4
HumaryantoAffiliation unknown4
Nyimas Natasha Ayu ShafiraAffiliation unknown4
Marizki PondawinataAffiliation unknown4
Afifah AmatullahAffiliation unknown3
Erny KusdiyahAffiliation unknown3
Denok Tri HardiningsihAffiliation unknown3
HafizahAffiliation unknown3
Attiya IstariniAffiliation unknown3
Mara Imam Taufiq SiregarAffiliation unknown3
Rita HalimAffiliation unknown3
Beni Hendro PrabowoAffiliation unknown3
FitriyantiAffiliation unknown3
Annissa DelfiraAffiliation unknown2
Nadir Putra Indra TariganAffiliation unknown2
Zilzikridini WijayantiAffiliation unknown2
KamariyahAffiliation unknown2
Armaidi DarmawanAffiliation unknown2
Amelia Dwi FitriAffiliation unknown2
Esa Indah AyudiaAffiliation unknown2
Muhammad SyukriUniversitas Halu Oleo2
Vina NeldiAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/PROCA/oai, first harvested 6 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Evaluation of the antidiabetic activity of ethyl acetate partition of ekor naga leaves (Rhaphidophora pinnata (L.f) Schott) on male white mice induced by alloxan</dc:title>
	<dc:creator xml:lang="en">Kasmadi, Fathnur Sani</dc:creator>
	<dc:creator xml:lang="en">Maimum</dc:creator>
	<dc:creator xml:lang="en">Yuliawati</dc:creator>
	<dc:creator xml:lang="en">Maharini, Indri</dc:creator>
	<dc:creator xml:lang="en">Sari, Vinka Lupita</dc:creator>
	<dc:creator xml:lang="en">Hz, Tia Wida Ekaputri</dc:creator>
	<dc:creator xml:lang="en">Perkasa, Tengku Arief Buana</dc:creator>
	<dc:subject xml:lang="en">Ekor naga leaves; antidiabetic; blood sugar; partition; alloxan</dc:subject>
	<dc:description xml:lang="en">Background: Diabetes mellitus is a condition where blood glucose levels increase due to a decrease in the amount or sensitivity of insulin produced by the body. Previous research has shown that the ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f.) Schott) has potential as an antidiabetic agent. The extract also contains several secondary metabolic compounds such as flavonoids and phenolics, which are suspected to have antidiabetic potential. Objective: This research aims to investigate the activity of ethyl acetate partitioning of Ekor Naga leaves extract (Rhaphidophora pinnata (L.f.) Schott) in reducing blood sugar levels in diabetic mice. Methods: This research employed a Completely Randomized Design (CRD) method with six treatments: a normal control, a glibenclamide positive control, a Na-CMC negative control, and treatment groups with doses of 125, 250, and 500 mg/kg body weight (BW) of the ethyl acetate partition of ekor naga leaves extract. The observed parameter was the average decrease in blood sugar levels over a 21-day period.Results: The results were analyzed using the one-way ANOVA test, followed by Duncan's multiple range test. The research showed that the ethyl acetate partition of Ekor Naga leaves can reduce blood sugar levels in mice over 21 days. The results have shown significant improvement in blood sugar levels between treatment groups. The best dose in reducing blood glucose levels was 500 mg/KgBW with a percentage decrease of 58.98%.Conclusion: Ethyl acetate partition of ekor naga leaves has potential as an antidiabetic agent.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/PROCA/article/view/50511</dc:identifier>
	<dc:identifier>10.22437/proca.v1i2.50511</dc:identifier>
	<dc:source xml:lang="en">Proceedings Academic Universitas Jambi; Vol. 1 No. 2 (2025): The 6th Jambi Medicine and Health Science International Conference (JAMHESIC); 929-934</dc:source>
	<dc:source>10.22437/proca.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/PROCA/article/view/50511/22710</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Fathnur Sani Kasmadi, Maimum, Yuliawati, Indri Maharini, Vinka Lupita Sari, Tia Wida Ekaputri Hz, Tengku Arief Buana Perkasa</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>