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Characteristic of the neutrophil-to-lymphocyte ratio (NLR) in patients with chronic low back pain

Proceedings Academic Universitas Jambi · Vol. 1 No. 2 (2025) · pp. 994–1000

DOI
10.22437/proca.v1i2.50525
Published
2025-11-30
Publisher
LPPM Universitas Jambi
Language
en
License
creativecommons.org/licenses/by/4.0

Abstract

Background: Chronic low back pain (LBP) constitutes a worldwide public health issue that substantially impacts a considerable segment of the adult demographic. The Neutrophil-to-Lymphocyte Ratio (NLR) is recognized as a significant inflammatory biomarker for multiple health conditions, including musculoskeletal disorders like low back pain (LBP). Objective: The assessment of NLR in patients with LBP has aimed to identify a potential biomarker for elucidating the mechanisms underlying inflammation and chronic pain. Methods: This research is a cross-sectional analytical study. All samples in this study underwent a complete blood cell count examination. The neutrophil-to-lymphocyte ratio is calculated by dividing the neutrophil count by the lymphocyte count in routine blood test results. Statistical tests were conducted using SPSS software. Results: This study involved 31 participants. The analysis of the NLR indicated that 77.4% of participants were categorized as moderate, whereas 22.6% were classified as high. Furthermore, 18 individuals (58.06%) reported experiencing moderate pain (NPRS 4-6), while 13 individuals (41.94%) indicated severe pain (NPRS 7-10). Conclusion: This study found 77.4% of subjects had moderate NLR. Despite moderate to severe pain, their systemic inflammatory response had not fully established, as shown by a lack of NLR increase.

Keywords

Collaboration network of the authors

40 authors · 224 co-authorship links · showing the 40 most connected

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Co-authorOrganisationJoint articles
Huntari HarahapAffiliation unknown7
Wahyu Indah Dewi AuroraAffiliation unknown6
KamariyahAffiliation unknown4
Tia Wida EkaputriAffiliation unknown4
Hasna DewiAffiliation unknown4
Esa Indah AyudiaAffiliation unknown4
Denok Tri HardiningsihAffiliation unknown4
Raihanah SuzanAffiliation unknown4
Mirna Marhami IskandarAffiliation unknown3
Fitriyanti FitriyantiAffiliation unknown3
Lipinwati LipinwatiAffiliation unknown3
FairuzAffiliation unknown3
Niken Irfa NastitiAffiliation unknown3
Armaidi DarmawanAffiliation unknown3
Tengku Arief Buana PerkasaAffiliation unknown3
HafizahAffiliation unknown3
Putri Sari WulandariAffiliation unknown3
HumaryantoAffiliation unknown2
YuliawatiAffiliation unknown2
Andika SulistiawanAffiliation unknown2
Rina Nofri EnisAffiliation unknown2
MiftahurrahmahAffiliation unknown2
Tia Wida Ekaputri HzAffiliation unknown2
Rita HalimAffiliation unknown2
Budi AswinAffiliation unknown2
Hanina HaninaAffiliation unknown2
Elisma ElismaAffiliation unknown1
guspianto guspiantoAffiliation unknown1
Vinna Rahayu NingsihAffiliation unknown1
Andi AmirAffiliation unknown1
Fathnur Sani KasmadiAffiliation unknown1
FitrianingsihAffiliation unknown1
Andy AmirAffiliation unknown1
Vinna Rahayu NingsihAffiliation unknown1
GuspiantoAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/PROCA/oai, first harvested 6 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Characteristic of the neutrophil-to-lymphocyte ratio (NLR) in patients with chronic low back pain</dc:title>
	<dc:creator xml:lang="en">Istarini, Attiya</dc:creator>
	<dc:creator xml:lang="en">Lipinwati</dc:creator>
	<dc:creator xml:lang="en">Hanina</dc:creator>
	<dc:creator xml:lang="en">Justitia, Budi</dc:creator>
	<dc:creator xml:lang="en">Fitriyanti</dc:creator>
	<dc:subject xml:lang="en">Neutrophil-to-Lymphocyte Ratio (NLR); Chronic Low Back Pain (LBP); Inflammatory responses</dc:subject>
	<dc:description xml:lang="en">Background: Chronic low back pain (LBP) constitutes a worldwide public health issue that substantially impacts a considerable segment of the adult demographic. The Neutrophil-to-Lymphocyte Ratio (NLR) is recognized as a significant inflammatory biomarker for multiple health conditions, including musculoskeletal disorders like low back pain (LBP). Objective: The assessment of NLR in patients with LBP has aimed to identify a potential biomarker for elucidating the mechanisms underlying inflammation and chronic pain. Methods: This research is a cross-sectional analytical study. All samples in this study underwent a complete blood cell count examination. The neutrophil-to-lymphocyte ratio is calculated by dividing the neutrophil count by the lymphocyte count in routine blood test results. Statistical tests were conducted using SPSS software. Results: This study involved 31 participants. The analysis of the NLR indicated that 77.4% of participants were categorized as moderate, whereas 22.6% were classified as high. Furthermore, 18 individuals (58.06%) reported experiencing moderate pain (NPRS 4-6), while 13 individuals (41.94%) indicated severe pain (NPRS 7-10). Conclusion: This study found 77.4% of subjects had moderate NLR. Despite moderate to severe pain, their systemic inflammatory response had not fully established, as shown by a lack of NLR increase.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/PROCA/article/view/50525</dc:identifier>
	<dc:identifier>10.22437/proca.v1i2.50525</dc:identifier>
	<dc:source xml:lang="en">Proceedings Academic Universitas Jambi; Vol. 1 No. 2 (2025): The 6th Jambi Medicine and Health Science International Conference (JAMHESIC); 994-1000</dc:source>
	<dc:source>10.22437/proca.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/PROCA/article/view/50525/22723</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Attiya Istarini, Lipinwati, Hanina, Budi Justitia, Fitriyanti</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>