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Effects of Young Areca Nut (Areca catechu L.) Administration on the Splenic Histopathological Features of Adult Sprague–Dawley Rats (Rattus norvegicus)

Scientific Of Environmental Health and Diseases · Vol. 1 No. 1 (2021) · pp. 35–43

DOI
10.22437/esehad.v1i1.10764
ISSN
2774-4337
Published
2021-06-17
Publisher
LPPM Universitas Jambi
Language
en

Abstract

ABSTRACT Background: Areca’s seed is an herbal beverage that are widely consumed as a betel nut. Areca’s seed contains arecoline. High doses of arecoline can damage many organ include spleen. There has been no further histopathological research of the effects with lower doses of betel nut on spleen.Methods: Ten rats Sprague Dawley strain white rats, aged 2-3 months, with 150-200 of grams were divided into 2 groups, namely the control group given aquades and the treatment group given areca nut dose of 50mg/kgBB for 28 days by feeding tube. Histopathologi’s indicators with hematoxilin eosin staining were analyzed by light microscope with 40X for diameter white pulp, 100X for congestion, and 400X for hematopoiesis extrmedullery and necrosis. The assessment for hematopoiesis extramedullery and necrosis used 5 high power-field, congestion used 3 high power field, and changes of diameter whites pulp used 10 high power-field. The data were analyzed by T- Independent statistical test.Results: Average congestion and hematopoiesis extramedullery of treatment group greater than control with p value 0,05).Conclusion: Areca’ seed doses 50 mg/KgWB that given for 28 days showed congestion and extra medullary hematopoiesis on rat’s spleen tissue.

Keywords

Collaboration network of the authors

40 authors · 246 co-authorship links · 7 across different organisations · showing the 40 most connected

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  • Gunma University
  • Universitas Jambi
  • Padjadjaran University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Anggelia PuspasariAffiliation unknown9
Amelia Dwi FitriAffiliation unknown8
Erny KusdiyahAffiliation unknown8
Nyimas Natasha Ayu ShafiraAffiliation unknown6
Rina Nofri EnisAffiliation unknown6
Susan TarawifaAffiliation unknown4
Citra MaharaniAffiliation unknown4
Wahyu Indah Dewi AuroraAffiliation unknown4
Ahmad SyauqyAffiliation unknown4
Randy PradityoAffiliation unknown3
Helda RahmasariAffiliation unknown3
Fairuz FairuzAffiliation unknown3
Lipinwati LipinwatiAffiliation unknown3
Asro Hayani HarahapAffiliation unknown3
Esa Indah AyudiaAffiliation unknown3
Raihanah SuzanAffiliation unknown3
Galih PurwoAffiliation unknown2
Tia Wida EkaputriAffiliation unknown2
Attiya IstariniAffiliation unknown2
HafizahAffiliation unknown2
Denok Tri HardiningsihAffiliation unknown2
ELFIANI ELFIANIAffiliation unknown2
Anati PurwakanthiAffiliation unknown2
Hanina HaninaAffiliation unknown2
Putri Sari WulandariAffiliation unknown2
Huntari HarahapAffiliation unknown2
Rita HalimAffiliation unknown2
MiftahurrahmahAffiliation unknown2
Mirna Marhami IskandarAffiliation unknown2
Patrick William GadingAffiliation unknown2
Armaidi DarmawanAffiliation unknown2
Irawan Anasta PutraAffiliation unknown2
Budi HandonoPadjadjaran University1
Leri S. FariedGunma University1
Ahmad FarriedGunma University1
Hiroyuki KuwantoGunma University1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/e-sehad/oai, first harvested 6 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Effects of Young Areca Nut (Areca catechu L.) Administration on the Splenic Histopathological Features of Adult Sprague–Dawley Rats (Rattus norvegicus)</dc:title>
	<dc:creator xml:lang="en">Adrian, Adek</dc:creator>
	<dc:creator xml:lang="en">Rahman, Ave Olivia</dc:creator>
	<dc:creator xml:lang="en">Herlambang, Herlambang</dc:creator>
	<dc:creator xml:lang="en">Dewi, Hasna</dc:creator>
	<dc:subject xml:lang="en">Areca catechu L</dc:subject>
	<dc:subject xml:lang="en">Betel nut</dc:subject>
	<dc:subject xml:lang="en">Toxicity</dc:subject>
	<dc:subject xml:lang="en">hematopoiesis extramedullery</dc:subject>
	<dc:description xml:lang="en">ABSTRACT
Background: Areca’s seed is an herbal beverage that are widely consumed as a betel nut. Areca’s seed contains arecoline. High doses of arecoline can damage many organ include spleen. There has been no further histopathological research of the effects with lower doses of betel nut on spleen.Methods: Ten rats Sprague Dawley strain white rats, aged 2-3 months, with 150-200 of grams were divided into 2 groups, namely the control group given aquades and the treatment group given areca nut dose of 50mg/kgBB for 28 days by feeding tube. Histopathologi’s indicators with hematoxilin eosin staining were analyzed by light microscope with 40X for diameter white pulp, 100X for congestion, and 400X for hematopoiesis extrmedullery and necrosis. The assessment for hematopoiesis extramedullery and necrosis used 5 high power-field, congestion used 3 high power field, and changes of diameter whites pulp used 10 high power-field. The data were analyzed by T- Independent statistical test.Results: Average congestion and hematopoiesis extramedullery of treatment group greater than control with p value &amp;lt;0,05. Average necrosis and changes of diameter white pulp of treatment group greater than control group, but there is no significant difference statistically (p value &amp;gt;0,05).Conclusion: Areca’ seed doses 50 mg/KgWB that given for 28 days showed congestion and extra medullary hematopoiesis on rat’s spleen tissue.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2021-06-17</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/e-sehad/article/view/10764</dc:identifier>
	<dc:identifier>10.22437/esehad.v1i1.10764</dc:identifier>
	<dc:source xml:lang="en">Scientific Of Environmental Health and Diseases; Vol. 1 No. 1 (2021): Scientific of Envitonmental Health And Diseases; 35-43</dc:source>
	<dc:source>2774-4337</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/e-sehad/article/view/10764/25304</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Electronic Journal  Scientific of Environmental Health And Disease</dc:rights>
</oai_dc:dc>