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The Genetic Variation of Ace Gene Rs4343 Has Lack Association With Pre-Eclampsia: Case-Control Study In Jambi Malay Population

Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan · Vol. 13 No. 1 (2025) · pp. 60–66

DOI
10.22437/jmj.v13i1.41334
ISSN
2580-6874, 2339-269X
Published
2025-05-24
Publisher
FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI
Language
en

Abstract

Background: The PE is leading cause of maternal and neonatal mortality and morbidity worldwide. The etiology of PE remains not yet clearly identified, genetics contributed 20-40% of PE. The variation of the rs4343 gene was significant as a risk factor for PE and the severity of PE with effect sizes varying between studies. To the best of our knowledge, the association of rs4343 in the ACE gene for PE risk has not been reported to the population of Indonesia, especially the Jambi Malays. Aims: This study aims to reveal the association of Genetic Variation of ACE gene rs4343 with preeclampsia. Methods: This recent study was case-control, 78 pregnant women matching based on age and pregnancy number participated in this study. The preeclampsia diagnosis is based on the criteria of the American College of Obstetricians and Gynecologists. The genotyping method was tetra ARMS-PCR. Bivariate statistical analysis was performed. Results: The proportion of the AA genotype and AG genotype was slightly different between the two groups, but all GG genotypes suffered preeclampsia. The recessive model reported the GG/AG genotype has a higher risk of PE than the AA genotype (p-value 0.784; OR 1.16, 95% CI (0.40-3.41)). The allele model reported that the G allele (p-value 0.338; OR 1.59, 95% CI (0.62-4.14)) had a higher risk than the A allele. However, all those differences do not reach statistically significant. Conclusion: Genetic Variation of ACE gene rs4343 Has Lack Association with Pre-eclampsia.

Keywords

Collaboration network of the authors

40 authors · 251 co-authorship links · showing the 40 most connected

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  • Universitas Jambi
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Nyimas Natasha Ayu ShafiraAffiliation unknown53
Amelia Dwi FitriAffiliation unknown40
Erny KusdiyahAffiliation unknown30
Rita HalimAffiliation unknown20
Wahyu Indah Dewi AuroraAffiliation unknown18
Tia Wida EkaputriAffiliation unknown12
Tia Wida Ekaputri HzAffiliation unknown10
Ahmad SyauqyAffiliation unknown9
Afifah AmatullahAffiliation unknown8
ELFIANI ELFIANIAffiliation unknown8
Huntari HarahapAffiliation unknown7
Nadir Putra Indra TariganAffiliation unknown5
Andi SubandiAffiliation unknown5
HerlambangAffiliation unknown5
Asro Hayani HarahapAffiliation unknown4
Denok Tri HardiningsihAffiliation unknown4
Annissa DelfiraAffiliation unknown4
Randy PradityoAffiliation unknown3
Helda RahmasariAffiliation unknown3
Fathnur Sani KasmadiAffiliation unknown3
Hasna DewiAffiliation unknown3
Armaidi DarmawanAffiliation unknown3
Patrick William GadingAffiliation unknown3
Galih PurwoAffiliation unknown2
HafizahAffiliation unknown2
Zilzikridini WijayantiAffiliation unknown2
FairuzAffiliation unknown2
HumaryantoAffiliation unknown2
Mara Imam Taufiq SiregarAffiliation unknown2
Attiya IstariniAffiliation unknown2
Zahra Frizki AstyAffiliation unknown2
HaninaAffiliation unknown2
Ismi Nurwaqiah IbnuAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/kedokteran/oai, first harvested 6 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The Genetic Variation of Ace Gene Rs4343 Has Lack Association With Pre-Eclampsia: Case-Control Study In Jambi Malay Population</dc:title>
	<dc:creator xml:lang="en">Puspasari, Anggelia</dc:creator>
	<dc:creator xml:lang="en">Herlambang, Herlambang</dc:creator>
	<dc:creator xml:lang="en">Maharani, Citra</dc:creator>
	<dc:creator xml:lang="en">Perkasa, Tengku Arief Buana</dc:creator>
	<dc:creator xml:lang="en">Enis, Rina Nofri</dc:creator>
	<dc:creator xml:lang="en">Tarawifa, Susan </dc:creator>
	<dc:creator xml:lang="en">Syukur, Astian Nathaniel</dc:creator>
	<dc:subject xml:lang="en">Preeclampsia</dc:subject>
	<dc:subject xml:lang="en">ACE</dc:subject>
	<dc:subject xml:lang="en">Malay</dc:subject>
	<dc:subject xml:lang="en">rs4343</dc:subject>
	<dc:subject xml:lang="en">Indonesia</dc:subject>
	<dc:description xml:lang="en">Background: The PE is leading cause of maternal and neonatal mortality and morbidity worldwide. The etiology of PE remains not yet clearly identified, genetics contributed 20-40% of PE. The variation of the rs4343 gene was significant as a risk factor for PE and the severity of PE with effect sizes varying between studies. To the best of our knowledge, the association of rs4343 in the ACE gene for PE risk has not been reported to the population of Indonesia, especially the Jambi Malays. Aims: This study aims to reveal the association of Genetic Variation of ACE gene rs4343 with preeclampsia.
Methods: This recent study was case-control, 78 pregnant women matching based on age and pregnancy number participated in this study. The preeclampsia diagnosis is based on the criteria of the American College of Obstetricians and Gynecologists. The genotyping method was tetra ARMS-PCR. Bivariate statistical analysis was performed.
Results: The proportion of the AA genotype and AG genotype was slightly different between the two groups, but all GG genotypes suffered preeclampsia. The recessive model reported the GG/AG genotype has a higher risk of PE than the AA genotype (p-value 0.784; OR 1.16, 95% CI (0.40-3.41)). The allele model reported that the G allele (p-value 0.338; OR 1.59, 95% CI (0.62-4.14)) had a higher risk than the A allele. However, all those differences do not reach statistically significant.
Conclusion: Genetic Variation of ACE gene rs4343 Has Lack Association with Pre-eclampsia.</dc:description>
	<dc:publisher xml:lang="en">FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI</dc:publisher>
	<dc:date>2025-05-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/kedokteran/article/view/41334</dc:identifier>
	<dc:identifier>10.22437/jmj.v13i1.41334</dc:identifier>
	<dc:source xml:lang="en">Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan; Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan; 60-66</dc:source>
	<dc:source>2580-6874</dc:source>
	<dc:source>2339-269X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/kedokteran/article/view/41334/20987</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan</dc:rights>
</oai_dc:dc>