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Analysis of Serum Glutamate Pyruvate Transaminase (SGPT) and Serum Glutamate Oxaloacetate Transaminase (SGOT) Levels in the Blood of Rat Offspring (Rattus norvegicus) Treated with Soybean (Glycine max L.) Extract and Zinc

Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan · Vol. 14 No. 1 (2026) · pp. 31–37

DOI
10.22437/jmj.v14i1.41788
ISSN
2580-6874, 2339-269X
Published
2026-05-14
Publisher
FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI
Language
en

Abstract

Background: The liver is the largest metabolic organ and plays an important role in the body. Nutritional fulfilment is one factor in maintaining liver health. Liver function can be evaluated by measuring the levels of SGPT and SGOT enzymes in the blood. Soybean juice and zinc can support liver health by keeping SGPT and SGOT enzyme levels normal. Methods: This study was conducted between October and December 2024 at the Zoology Laboratory of the University of Lampung. This study used a Completely Randomized Design (CRD) included four treatment groups. Each treatment included five mice: control (K), treatment 1 (P1)- induced Soybean juice 0,6 mL/kg body weight (P2) induced Soybean 0,3 mL/kg body weight and Zinc 0,3 mL/kg body weight, and (P3) induced Soybean 0,6 mL/kg body weight and Zinc 0,6 mL/kg body weight for 14 days. Normal and homogeneous data were analyzed using analysis of variance (ANOVA) to determine whether the treatment's effect was significant. Differences were considered statistically significant at p < 0.05. Duncan's multiple interval post hoc test (=5%) was used to identify the most effective treatment. Result: Based on the results of the one-way ANOVA test with a 95% confidence interval, the average SGPT and SGOT levels in the K, P1, P2, and P3 treatments differ significantly. The average SGPT levels above show that the P2 and P3 groups experienced a significant decrease compared to the K and P1 treatments. Conclusion: Analysis of variance (ANOVA) showed that administering soya juice and zinc at an optimum dose of 1.2 mL/kg body weight can affect and maintain normal SGPT and SGOT levels.

Keywords

Collaboration network of the authors

13 authors · 51 co-authorship links · 1 across different organisations

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  • Lampung University
  • Universitas Muslim Indonesia
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
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Co-authorOrganisationJoint articles
Sulastri SulastriUniversitas Muslim Indonesia1
Muhammad Al-HafidzAffiliation unknown1
Yuniastini YuniastiniLampung University1
Purwati PurwatiAffiliation unknown1
Antun RahmadiAffiliation unknown1
Wien WiratmokoAffiliation unknown1
Iradah Lia PrasetioAffiliation unknown1
Fannia Khairani MzAffiliation unknown1
Mohammad Hafid HakAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/kedokteran/oai, first harvested 6 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Analysis of Serum Glutamate Pyruvate Transaminase (SGPT) and Serum Glutamate Oxaloacetate Transaminase (SGOT) Levels in the Blood of Rat Offspring (Rattus norvegicus) Treated with Soybean (Glycine max L.) Extract and Zinc</dc:title>
	<dc:creator xml:lang="en">Hafidz, Muhammad Al Hafidz</dc:creator>
	<dc:creator xml:lang="en">Busman, Hendri</dc:creator>
	<dc:creator xml:lang="en">Kanedi, M. Kanedi</dc:creator>
	<dc:creator xml:lang="en">Widiastuti, Endang Linirin</dc:creator>
	<dc:subject xml:lang="en">Liver</dc:subject>
	<dc:subject xml:lang="en">SGPT</dc:subject>
	<dc:subject xml:lang="en">SGOT</dc:subject>
	<dc:subject xml:lang="en">Soyabean</dc:subject>
	<dc:subject xml:lang="en">Zinc</dc:subject>
	<dc:description xml:lang="en">Background: The liver is the largest metabolic organ and plays an important role in the body. Nutritional fulfilment is one factor in maintaining liver health. Liver function can be evaluated by measuring the levels of SGPT and SGOT enzymes in the blood. Soybean juice and zinc can support liver health by keeping SGPT and SGOT enzyme levels normal.
Methods: This study was conducted between October and December 2024 at the Zoology Laboratory of the University of Lampung. This study used a Completely Randomized Design (CRD) included four treatment groups. Each treatment included five mice: control (K), treatment 1 (P1)- induced Soybean juice 0,6 mL/kg body weight (P2) induced Soybean 0,3 mL/kg body weight and Zinc 0,3 mL/kg body weight, and (P3) induced Soybean 0,6 mL/kg body weight and Zinc 0,6 mL/kg body weight for 14 days. Normal and homogeneous data were analyzed using analysis of variance (ANOVA) to determine whether the treatment's effect was significant. Differences were considered statistically significant at p &amp;lt; 0.05. Duncan's multiple interval post hoc test (=5%) was used to identify the most effective treatment.
Result: Based on the results of the one-way ANOVA test with a 95% confidence interval, the average SGPT and SGOT levels in the K, P1, P2, and P3 treatments differ significantly. The average SGPT levels above show that the P2 and P3 groups experienced a significant decrease compared to the K and P1 treatments.
Conclusion: Analysis of variance (ANOVA) showed that administering soya juice and zinc at an optimum dose of 1.2 mL/kg body weight can affect and maintain normal SGPT and SGOT levels.</dc:description>
	<dc:publisher xml:lang="en">FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI</dc:publisher>
	<dc:date>2026-05-14</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/kedokteran/article/view/41788</dc:identifier>
	<dc:identifier>10.22437/jmj.v14i1.41788</dc:identifier>
	<dc:source xml:lang="en">Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan; Vol. 14 No. 1 (2026): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan; 31-37</dc:source>
	<dc:source>2580-6874</dc:source>
	<dc:source>2339-269X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/kedokteran/article/view/41788/24311</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan</dc:rights>
</oai_dc:dc>