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Pangasius djambal gelatin increases osteoprotegerin, decreases RANK and RANKL after tooth extraction in vivo

Dental Journal (Majalah Kedokteran Gigi) · Vol. 56 No. 4 (2023) · hlm. 238–242

DOI
10.20473/j.djmkg.v56.i4.p238-242
ISSN
2442-9740, 1978-3728
Terbit
2023-09-01
Penerbit
Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Background: Osteoprotegerin (OPG) plays a role in preventing osteoclast formation and osteoclastic bone resorption by inhibiting the receptor activator nuclear factor-β and its ligand (RANK–RANKL) interaction that causes bone resorption. Pangasius djambal gelatin contains essential amino acids that may stimulate bone remodeling. Purpose: This study aimed to investigate the expressions of OPG, RANKL, and RANK following tooth extraction to ascertain whether OPG is associated with the RANKL and RANK ratios following gelatin induction. Methods: This study was a true experimental study with a simple, randomized post-test only control group design. Twenty-four albino rats (Rattus norvegicus) were divided into two groups (n = 4). The treatment group was treated with P. djambal gelatin following tooth extraction, while the control group was left untreated. Animal models undergoing tooth extraction were anesthetized intraperitoneally with ketamine (1,000 mg/10 ml up to 0.2 ml). The tooth was then extracted slowly so as not to break it. P. djambal gelatin was dripped (0.1 ml) into the socket after the extraction procedure. The association of OPG with RANKL and RANK immunohistochemistry expressions was evaluated after three, five, and seven days. Results: There was a significant increase in OPG expression on day 7 (P < 0.05) and a significant decrease in the expression of RANKL and RANK (P < 0.05) in the treatment group. Conclusion: The application of P. djambal gelatin could increase OPG expression, decrease RANKL and RANK expression in the socket following tooth extraction, and might be associated with the inhibition of bone resorption.

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  • State University of Semarang
  • Hasanuddin University
  • Diponegoro University
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Rekan penulisOrganisasiArtikel bersama
ULFATUN NIKMAHAfiliasi tidak diketahui1
Agung Dwi NugrohoAfiliasi tidak diketahui1
Wisnu SunartoAfiliasi tidak diketahui1
Sri NurhayatiAfiliasi tidak diketahui1
Firmansyah FirmansyahHasanuddin University1
Risma SeptianaDiponegoro University1
Ahmad Fashiha HastawanState University of Semarang1
Ritme Cahya AryaniAfiliasi tidak diketahui1
Veliana MarshaAfiliasi tidak diketahui1
Wulansari PrasetyaningtyasAfiliasi tidak diketahui1
Jefri Tri YuniartoAfiliasi tidak diketahui1
Eka Titi AndaryaniState University of Semarang1
Sri Prastiti Kusuma AnggraeniAfiliasi tidak diketahui1
Retno Sri IswariState University of Semarang1
Siti Harnina BintariAfiliasi tidak diketahui1
Isti HidayahAfiliasi tidak diketahui1
Nuriana Rachmani Dewi Nino AdhiAfiliasi tidak diketahui1
Azizah Dilla SafitriAfiliasi tidak diketahui1
Nadia Anggit TyaswariAfiliasi tidak diketahui1
Ro'ifah Ro'ifahAfiliasi tidak diketahui1
Sulton Dedi WijayaAfiliasi tidak diketahui1
Fatkhurrohman FatkhurrohmanAfiliasi tidak diketahui1
Fatiatun FatiatunAfiliasi tidak diketahui1
Reka SeprinaAfiliasi tidak diketahui1
Ali TrigiyatnoAfiliasi tidak diketahui1
Imam KanafiAfiliasi tidak diketahui1
Afiful - IkhwanAfiliasi tidak diketahui1
Fina Kholij ZukhrufinAfiliasi tidak diketahui1
Moh. SubhanAfiliasi tidak diketahui1
Irman IrawanAfiliasi tidak diketahui1
Seftylia DiachantyAfiliasi tidak diketahui1
Ita ZuraidaAfiliasi tidak diketahui1
Adlina ArdhanawinataAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/MKG/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Pangasius djambal gelatin increases osteoprotegerin, decreases RANK and RANKL after tooth extraction in vivo</dc:title>
	<dc:creator>Mardiyantoro, Fredy</dc:creator>
	<dc:creator>Prasetyaningrum, Nenny</dc:creator>
	<dc:creator>Hidayat, Lukman H.</dc:creator>
	<dc:creator>Khasanah, Uswatun</dc:creator>
	<dc:creator>Roring, Virginia C.</dc:creator>
	<dc:creator>Muizun, Ahida</dc:creator>
	<dc:creator>Kardikadewi, Varellia A. W.</dc:creator>
	<dc:subject xml:lang="en-US">medicine</dc:subject>
	<dc:subject xml:lang="en-US">osteoprotegerin</dc:subject>
	<dc:subject xml:lang="en-US">receptor activator nuclear factor-β</dc:subject>
	<dc:subject xml:lang="en-US">receptor activator nuclear factor-β ligand</dc:subject>
	<dc:subject xml:lang="en-US">tooth extraction</dc:subject>
	<dc:description xml:lang="en-US">Background: Osteoprotegerin (OPG) plays a role in preventing osteoclast formation and osteoclastic bone resorption by inhibiting the receptor activator nuclear factor-β and its ligand (RANK–RANKL) interaction that causes bone resorption. Pangasius djambal gelatin contains essential amino acids that may stimulate bone remodeling. Purpose: This study aimed to investigate the expressions of OPG, RANKL, and RANK following tooth extraction to ascertain whether OPG is associated with the RANKL and RANK ratios following gelatin induction. Methods: This study was a true experimental study with a simple, randomized post-test only control group design. Twenty-four albino rats (Rattus norvegicus) were divided into two groups (n = 4). The treatment group was treated with P. djambal gelatin following tooth extraction, while the control group was left untreated. Animal models undergoing tooth extraction were anesthetized intraperitoneally with ketamine (1,000 mg/10 ml up to 0.2 ml). The tooth was then extracted slowly so as not to break it. P. djambal gelatin was dripped (0.1 ml) into the socket after the extraction procedure. The association of OPG with RANKL and RANK immunohistochemistry expressions was evaluated after three, five, and seven days. Results: There was a significant increase in OPG expression on day 7 (P &amp;lt; 0.05) and a significant decrease in the expression of RANKL and RANK (P &amp;lt; 0.05) in the treatment group. Conclusion: The application of P. djambal gelatin could increase OPG expression, decrease RANKL and RANK expression in the socket following tooth extraction, and might be associated with the inhibition of bone resorption. </dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en</dc:publisher>
	<dc:date>2023-09-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>text/xml</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/MKG/article/view/41046</dc:identifier>
	<dc:identifier>10.20473/j.djmkg.v56.i4.p238-242</dc:identifier>
	<dc:source xml:lang="en-US">Dental Journal (Majalah Kedokteran Gigi); Vol. 56 No. 4 (2023): December; 238-242</dc:source>
	<dc:source>2442-9740</dc:source>
	<dc:source>1978-3728</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/41046/39733</dc:relation>
	<dc:relation>https://e-journal.unair.ac.id/MKG/article/view/41046/25914</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Dental Journal</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>