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Pathological Investigation of Lumpy Skin Disease in Cattle from Sleman, Indonesia

Jurnal Medik Veteriner · Vol. 8 No. 2 (2025) · hlm. 414–423

DOI
10.20473/jmv.vol8.iss2.2025.414-423
ISSN
2581-012X, 2615-7497
Terbit
2025-10-01
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

In early 2023, there was an outbreak of lumpy skin disease (LSD) in cattle in Indonesia, with particularly high prevalence in Sleman, Special Region of Yogyakarta, Indonesia. Since then, cases of this disease have been increasing, causing significant economic losses to cattle and buffalo farmers. This study aimed to investigate the pathological changes caused by LSD virus infection in various organs of Sleman cattle. We investigated 15 animals from 10 farms. Skin samples were taken by biopsy. ELISA testing was performed on serum samples. We also performed necropsies on two LSD infected cow carcasses to observe the macroscopic and microscopic effects of the virus. During the necropsies, samples were obtained from skin nodules, skeletal muscle, and internal organs (lung, liver, kidney, lymphatic nodes, spleen, and digestive organs). These were subjected to histopathological examination using hematoxylin and eosin staining. Among the live animals, fever, lethargy, hypersalivation, and lacrimation were the most common clinical signs. Our qualitative descriptive analysis of the pathological changes, clinical signs, and ELISA results showed that LSD infection in cattle causes mild to severe damage to various organs. Our macroscopic examinations found that affected animals had skin nodules of varying sizes over the entire body. We observed mild to severe inflammation and hemorrhage in the internal organs, including the skeletal muscles, spleen, liver, heart, rumen, reticulum, abomasum, and small intestine. Based on this investigation, we conclude that, in addition to its effects on the skin, LSD causes pathological changes in various internal organs.

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  • Universitas Gadjah Mada
  • Jenderal Soedirman University
  • Ministry of Agriculture
  • Sebelas Maret University
  • State University of Semarang
  • Universitas Pattimura
  • Ehime University
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Rekan penulisOrganisasiArtikel bersama
Michael Haryadi WibowoUniversitas Gadjah Mada6
Widya AsmaraUniversitas Gadjah Mada3
Rendie PrasetyoJenderal Soedirman University2
Aqib Ossa Eldurr IftitahAfiliasi tidak diketahui1
Yulias Ninik WindriyatiAfiliasi tidak diketahui1
Adolf Z.D SiahayAfiliasi tidak diketahui1
Simson WerimonAfiliasi tidak diketahui1
Masrukan MasrukanState University of Semarang1
Wahyu HardyantoAfiliasi tidak diketahui1
Liza AngeliyaUniversitas Gadjah Mada1
Ferdinand Prayogo Cahyo SantosoUniversitas Gadjah Mada1
Rini WidayantiUniversitas Gadjah Mada1
Heru SusetyaUniversitas Gadjah Mada1
Khrisdiana PutriUniversitas Gadjah Mada1
Charles Rangga TabbuUniversitas Gadjah Mada1
Haryadi M. WibowoUniversitas Gadjah Mada1
Sidna ArtantoUniversitas Gadjah Mada1
Krisdiana PutriUniversitas Gadjah Mada1
Surya AmanuUniversitas Gadjah Mada1
Mustofa MustofaUniversitas Gadjah Mada1
Eti Nurwening SholikhahUniversitas Gadjah Mada1
Jumina JuminaUniversitas Gadjah Mada1
Ruslin HadanuUniversitas Pattimura1
Koichi AkiyamaEhime University1
Eko Agus SrihantoMinistry of Agriculture1
Dewi Noor HidayatiMinistry of Agriculture1
Prita Sari DewiJenderal Soedirman University1
Sri LestariJenderal Soedirman University1
Anindya Puspaning TyasJenderal Soedirman University1
Dea Yuniar IndikasuriJenderal Soedirman University1
Paul A. DavisonUniversity of Sheffield1
Djati Waluyo DjoarSebelas Maret University1
Panut SahariSebelas Maret University1
Bart Julien DewanckerThe University of Kitakyushu1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JMV/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Pathological Investigation of Lumpy Skin Disease in Cattle from Sleman, Indonesia</dc:title>
	<dc:creator>Kristianingrum, Yuli Purwandari </dc:creator>
	<dc:creator>Winarsih, Sugi</dc:creator>
	<dc:creator>Sutrisno, Bambang</dc:creator>
	<dc:creator>Widyarini, Sitarina</dc:creator>
	<dc:creator>Sugiyono, Sugiyono</dc:creator>
	<dc:creator>Untari, Tri</dc:creator>
	<dc:subject xml:lang="en-US">dermatitis</dc:subject>
	<dc:subject xml:lang="en-US">hemorrhage</dc:subject>
	<dc:subject xml:lang="en-US">lumpy skin disease</dc:subject>
	<dc:subject xml:lang="en-US">skin nodules</dc:subject>
	<dc:description xml:lang="en-US">In early 2023, there was an outbreak of lumpy skin disease (LSD) in cattle in Indonesia, with particularly high prevalence in Sleman, Special Region of Yogyakarta, Indonesia. Since then, cases of this disease have been increasing, causing significant economic losses to cattle and buffalo farmers. This study aimed to investigate the pathological changes caused by LSD virus infection in various organs of Sleman cattle. We investigated 15 animals from 10 farms. Skin samples were taken by biopsy. ELISA testing was performed on serum samples. We also performed necropsies on two LSD infected cow carcasses to observe the macroscopic and microscopic effects of the virus. During the necropsies, samples were obtained from skin nodules, skeletal muscle, and internal organs (lung, liver, kidney, lymphatic nodes, spleen, and digestive organs). These were subjected to histopathological examination using hematoxylin and eosin staining. Among the live animals, fever, lethargy, hypersalivation, and lacrimation were the most common clinical signs. Our qualitative descriptive analysis of the pathological changes, clinical signs, and ELISA results showed that LSD infection in cattle causes mild to severe damage to various organs. Our macroscopic examinations found that affected animals had skin nodules of varying sizes over the entire body. We observed mild to severe inflammation and hemorrhage in the internal organs, including the skeletal muscles, spleen, liver, heart, rumen, reticulum, abomasum, and small intestine. Based on this investigation, we conclude that, in addition to its effects on the skin, LSD causes pathological changes in various internal organs.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2025-10-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>text/xml</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JMV/article/view/73559</dc:identifier>
	<dc:identifier>10.20473/jmv.vol8.iss2.2025.414-423</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Medik Veteriner; Vol. 8 No. 2 (2025): October; 414-423</dc:source>
	<dc:source>2581-012X</dc:source>
	<dc:source>2615-7497</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/73559/34082</dc:relation>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/73559/35268</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Yuli Purwandari  Kristianingrum, Sugi Winarsih, Bambang Sutrisno, Sitarina Widyarini, Sugiyono Sugiyono, Tri Untari</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>