PENENTUAN KADAR HAMBAT MINIMUM EKSTRAK ETANOL RIMPANG Etlingera alba (Blume) A. D. Poulsen TERHADAP BAKTERI PENYEBAB DIARE Cronobacter muytjensii DAN PENGEMBANGANNYA DALAM SEDIAAN GRANUL

Fristiohady, Adryan; Andriani, Rina; Ramadhani, Rizky Barkah; wahyuni, Wahyuni; Muzuni, Muzuni; Bafadal, Mentarry; Sani, Asrul; Aspadiah, Vica; Sari, Puspita; Sahidin, Sahidin

doi:10.33772/jstp.v5i5.15099

Jurnal

PENENTUAN KADAR HAMBAT MINIMUM EKSTRAK ETANOL RIMPANG Etlingera alba (Blume) A. D. Poulsen TERHADAP BAKTERI PENYEBAB DIARE Cronobacter muytjensii DAN PENGEMBANGANNYA DALAM SEDIAAN GRANUL

Jurnal Sains dan Teknologi Pangan · Vol. 5 No. 5 (2020)

DOI: 10.33772/jstp.v5i5.15099
ISSN: 2527-6271
Published: 2020-11-16
Publisher: JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO
Language: eng

Abstract

ABSTRACT This study aimed to determine the potential inhibition of ethanol extract of Etlingera alba rhizome against the Cronobacter muytjensiis bacteria and its development in a granule dosage form. Measurement of Minimum Inhibitory Concentration (MIC) using the Broth Microdilution method while granule formulation used the wet granulation method. The results of this study indicate a concentration of 32μg/mL in C. muytjensii as an inhibition of bacterial growth by looking at the absorbance value that was close to 0 and confirmed by spectrophotometric results to see the turbidity of each concentration. This study used 12 extract concentrations, namely 2, 4, 8, 16, 32, 64, 128, 256, 512, 102, and 4096 μg/mL. The granule formulation used 5% gelatin as a binder, Explotab® 4%, 1% magnesium stearate, aerosil PH 101 4%, and lactose ad. 100%. Tablets of ethanol extract of E. alba rhizome qualified for evaluation of weight uniformity and size uniformity evaluation tests.Keywords:Etlingera alba, MIC, granulABSTRAKPenelitian ini bertujuan untuk mengetahui potensi penghambatan ekstrak etanol rimpang Etlingera alba terhadap bakteriCronobacter muytjensiiserta pengembangannya dalam bentuk sediaan granul. Pengukuran Minimum Inhibitory Concentration (MIC) dengan metode Broth Microdilutiondan formulasi granul menggunakan metode granulasi basah.Hasil penelitian ini menunjukkan konsentrasi 32μg/mL pada C. muytjensii sebagai penghambatan pertumbuhan bakteri dengan melihat nilai absorbansi yang mendekati 0 dan dikonfirmasi dengan hasil spektrofotometri untuk melihat turbiditas masing-masing konsentrasi.Penelitian ini menggunakan 12 konsentrasi ekstrak yaitu 2, 4, 8, 16, 32, 64, 128, 256, 512, 102 dan 4096 μg/mL. Formulasi granul menggunakan bahan gelatin 5% sebagai pengikat, Explotab® 4%, magnesium stearat 1%, aerosil PH 101 4% dan laktosa ad. 100%. Tablet ekstrak etanol rimpangE. alba telah memenuhi uji evaluasi berupa keseragaman bobot dan uji evaluasi keseragaman ukuranKata kunci: Etlingera alba, MIC, granul

Collaboration network of the authors

40 authors · 130 co-authorship links · 1 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

Universitas Halu Oleo
Jordan University of Science and Technology
Affiliation unknown

Different organisations
Same organisation
Affiliation unknown
Thicker line = more joint articles · bigger circle = more articles

Show as table

Co-author	Organisation	Joint articles
Fadhliyah Malik	Affiliation unknown	9
Muhammad Hajrul Malaka	Affiliation unknown	6
Rini Hamsidi	Affiliation unknown	4
Mustamin Anggo	Universitas Halu Oleo	3
Ruslin Ruslin	Universitas Halu Oleo	3
Henny Kasmawati	Universitas Halu Oleo	3
Analuddin Analuddin	Universitas Halu Oleo	2
Suriana Suriana	Affiliation unknown	2
Jahidin Jahidin	Affiliation unknown	2
Hafiludin Samparadja	Affiliation unknown	2
Nur Arfa Yanti	Affiliation unknown	2
Dirvamena Boer	Universitas Halu Oleo	2
Sunandar Ihsan	Universitas Halu Oleo	2
Nur Illiyyin Akib	Affiliation unknown	2
Suryani Suryani	Universitas Halu Oleo	2
SRI WAHYUNI	Affiliation unknown	2
Ramadhan Tosepu	Universitas Halu Oleo	1
Rini Rini	Universitas Halu Oleo	1
Ahmad Mustafa	Jordan University of Science and Technology	1
Ma’ruf Kasim	Universitas Halu Oleo	1
Abdul Muis Balubi	Affiliation unknown	1
Wardha Jalil	Affiliation unknown	1
Yusnaini Yusnaini	Universitas Halu Oleo	1
Muh Yamin Effendie	Affiliation unknown	1
Haristan Haristan	Affiliation unknown	1
Sri Ambardini	Universitas Halu Oleo	1
Darwis Suleman	Universitas Halu Oleo	1
Alias Alias	Affiliation unknown	1
Harleli Harleli	Universitas Halu Oleo	1
Sartiah Yusran	Affiliation unknown	1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/jstp/oai, first harvested 31 Okt 2026, last seen 31 Okt 2026.

Original metadata (oai_dc)

<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">PENENTUAN KADAR HAMBAT MINIMUM EKSTRAK ETANOL RIMPANG Etlingera alba (Blume) A. D. Poulsen TERHADAP BAKTERI PENYEBAB DIARE Cronobacter muytjensii DAN PENGEMBANGANNYA DALAM SEDIAAN GRANUL</dc:title>
	<dc:creator>Fristiohady, Adryan</dc:creator>
	<dc:creator>Andriani, Rina</dc:creator>
	<dc:creator>Ramadhani, Rizky Barkah</dc:creator>
	<dc:creator>wahyuni, Wahyuni</dc:creator>
	<dc:creator>Muzuni, Muzuni</dc:creator>
	<dc:creator>Bafadal, Mentarry</dc:creator>
	<dc:creator>Sani, Asrul</dc:creator>
	<dc:creator>Aspadiah, Vica</dc:creator>
	<dc:creator>Sari, Puspita</dc:creator>
	<dc:creator>Sahidin, Sahidin</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACT This study aimed to determine the potential inhibition of ethanol extract of Etlingera alba rhizome against the Cronobacter muytjensiis bacteria and its development in a granule dosage form. Measurement of Minimum Inhibitory Concentration (MIC) using the Broth Microdilution method while granule formulation used the wet granulation method. The results of this study indicate a concentration of 32μg/mL in C. muytjensii as an inhibition of bacterial growth by looking at the absorbance value that was close to 0 and confirmed by spectrophotometric results to see the turbidity of each concentration. This study used 12 extract concentrations, namely 2, 4, 8, 16, 32, 64, 128, 256, 512, 102, and 4096 μg/mL. The granule formulation used 5% gelatin as a binder, Explotab® 4%, 1% magnesium stearate, aerosil PH 101 4%, and lactose ad. 100%. Tablets of ethanol extract of E. alba rhizome qualified for evaluation of weight uniformity and size uniformity evaluation tests.Keywords:Etlingera alba, MIC, granulABSTRAKPenelitian ini bertujuan untuk mengetahui potensi penghambatan ekstrak etanol rimpang Etlingera alba terhadap bakteriCronobacter muytjensiiserta pengembangannya dalam bentuk sediaan granul. Pengukuran Minimum Inhibitory Concentration (MIC) dengan metode Broth Microdilutiondan formulasi granul menggunakan metode granulasi basah.Hasil penelitian ini menunjukkan konsentrasi 32μg/mL pada C. muytjensii sebagai penghambatan pertumbuhan bakteri dengan melihat nilai absorbansi yang mendekati 0 dan dikonfirmasi dengan hasil spektrofotometri untuk melihat turbiditas masing-masing konsentrasi.Penelitian ini menggunakan 12 konsentrasi ekstrak yaitu 2, 4, 8, 16, 32, 64, 128, 256, 512, 102 dan 4096 μg/mL. Formulasi granul menggunakan bahan gelatin 5% sebagai pengikat, Explotab® 4%, magnesium stearat 1%, aerosil PH 101 4% dan laktosa ad. 100%. Tablet ekstrak etanol rimpangE. alba telah memenuhi uji evaluasi berupa keseragaman bobot dan uji evaluasi keseragaman ukuranKata kunci: Etlingera alba, MIC, granul</dc:description>
	<dc:publisher xml:lang="en-US">JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2020-11-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/jstp/article/view/15099</dc:identifier>
	<dc:identifier>10.33772/jstp.v5i5.15099</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Sains dan Teknologi Pangan; Vol 5, No 5 (2020): Jurnal Sains dan Teknologi Pangan</dc:source>
	<dc:source>2527-6271</dc:source>
	<dc:source>10.33772/jstp.v5i5</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/jstp/article/view/15099/10292</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Jurnal Sains dan Teknologi Pangan</dc:rights>
</oai_dc:dc>