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ELEVATED UNCONJUGATED BILIRUBIN IN SCHIZOPHRENIC PATIENTS

Nusantara Medical Science Journal · Vol. ume No. 1 (2018) · hlm. 20–26

DOI
10.20956/nmsj.v3i1.5780
ISSN
2597-7288, 2460-9757
Terbit
2018-06-01
Penerbit
Faculty of Medicine, Hasanuddin University.
Bahasa
en

Abstrak

Strategies for schizophrenic treatment still have been developed in order to increase their effectively, based on latest findings in the etio-pathology. Coincidence of hyperbilirubinemia, especially related to Gilbert’s Syndrome (GS), and schizophrenia/other psychiatric disorders, was reported in several studies although the pattern of this alteration is still controversial. Bilirubin could induce microglia to release pro-inflammatory cytokine that cause neuroinflammation, one of hypothetic etio-pathogenesis has been the most extensively studied recently. However, no data have been presented about this phenomenon in Indonesia. Therefore, this study aims to investigate plasma bilirubin concentration in psychotic spectrum.This study is cross sectional design that we examined both the total bilirubin and direct bilirubin of every psychotic patient admitted for the first time to Rumah Sakit Khusus Daerah (RSKD) Provinsi Sulawesi Selatan over a period of July—December 2012, by using health people as control. Diagnostic determination was set based on International Classification of Diseases (ICD) 10. Patients suffering from any disease such as anemia (decreased hemoglobin), liver diseases (elevated liver enzymes), or substance abuse were excluded. From 73 samples, we found that plasma UCB level was significantly elevated, higher in psychotic patients, especially schizophrenic group, than in the control. Total bilirubin rate was slightly increased in schizophrenic group compare to the others and two samples in this group showed hyperbilirubinemia. Further investigations are needed to ensure that whether the elevated UCB was related to GS and whether this condition has inflammatory effect.

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Rekan penulisOrganisasiArtikel bersama
Lita Paramitha AprianiAfiliasi tidak diketahui1
Rachmawati A. MuhiddinAfiliasi tidak diketahui1
Kusrini KadarAfiliasi tidak diketahui1
Meyke Tiku PasangAfiliasi tidak diketahui1
Chyntia Novita KalaloAfiliasi tidak diketahui1
Elly Lilianty SjattarAfiliasi tidak diketahui1
Firmansyah FirmansyahUniversitas Pancasakti Makassar1
Andi Detti YuniantiAfiliasi tidak diketahui1
Asmita AhmadAfiliasi tidak diketahui1
Kidung Putra PangestuAfiliasi tidak diketahui1
Ashar Ramadan SyahAfiliasi tidak diketahui1
Nur Indah PurnamasariAfiliasi tidak diketahui1
Muhammad SabirAfiliasi tidak diketahui1
SRI WAHYUNIAfiliasi tidak diketahui1
Burhanuddin BaharAfiliasi tidak diketahui1
Firdaus HamidAfiliasi tidak diketahui1
Mochammad HattaAfiliasi tidak diketahui1
Ahyar AhmadAfiliasi tidak diketahui1
Ade Rifka JunitaAfiliasi tidak diketahui1
Ressy DwiyantiAfiliasi tidak diketahui1
Muhammad Reza PrimagunaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">ELEVATED UNCONJUGATED BILIRUBIN  IN SCHIZOPHRENIC PATIENTS</dc:title>
	<dc:creator xml:lang="en">Aziz, Ilhamuddin</dc:creator>
	<dc:creator xml:lang="en">Widaningsih, Yuyun</dc:creator>
	<dc:creator xml:lang="en">Natzir, Rosdiana</dc:creator>
	<dc:creator xml:lang="en">Tanra, A. Jayalangkara</dc:creator>
	<dc:subject xml:lang="en">Unconjugated bilirubin</dc:subject>
	<dc:subject xml:lang="en">Gilbert’s syndrome</dc:subject>
	<dc:subject xml:lang="en">psychoses</dc:subject>
	<dc:subject xml:lang="en">schizophrenia</dc:subject>
	<dc:description xml:lang="en">Strategies for schizophrenic treatment still have been developed in order to increase their effectively, based on latest findings in the etio-pathology. Coincidence of hyperbilirubinemia, especially related to Gilbert’s Syndrome (GS), and schizophrenia/other psychiatric disorders, was reported in several studies although the pattern of this alteration is still controversial.  Bilirubin could induce microglia to release pro-inflammatory cytokine that cause neuroinflammation, one of hypothetic etio-pathogenesis has been the most extensively studied recently. However, no data have been presented about this phenomenon in Indonesia. Therefore, this study aims to investigate plasma bilirubin concentration in psychotic spectrum.This study is cross sectional design that we examined both the total bilirubin and direct bilirubin of every psychotic patient admitted for the first time to Rumah Sakit Khusus Daerah (RSKD) Provinsi Sulawesi Selatan over a period of July—December 2012, by using health people as control. Diagnostic determination was set based on International Classification of Diseases (ICD) 10. Patients suffering from any disease such as anemia (decreased hemoglobin), liver diseases (elevated liver enzymes), or substance abuse were excluded.            From 73 samples, we found that plasma UCB level was significantly elevated, higher in psychotic patients, especially schizophrenic group, than in the control. Total bilirubin rate was slightly increased in schizophrenic group compare to the others and two samples in this group showed hyperbilirubinemia. Further investigations are needed to ensure that whether the elevated UCB was related to GS and whether this condition has inflammatory effect.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2018-06-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/5780</dc:identifier>
	<dc:identifier>10.20956/nmsj.v3i1.5780</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 3 No. 1  Januari - Juni 2018; 20-26</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.v3i1</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/5780/3261</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2018 Nusantara Medical Science Journal</dc:rights>
</oai_dc:dc>