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Studi In Silico Senyawa Bioaktif Daun Sendok (Plantago Major) Sebagai Antidibetes

Indonesian Journal of Mathematics and Natural Sciences · Vol. 49 No. 1 (2026) · hlm. 29–41

DOI
10.15294/jm.v49i1.22000
ISSN
2774-7832
Terbit
2026-10-05
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Diabetes Mellitus is a disease caused by decreased pancreatic function to produce insulin or insensitivity of insulin receptors. This research aims to analyse the bioactive compounds in spoon leaves as antidiabetics and the mechanism of action in silico. Bioactive compounds were collected using Dr. Duke's Phytochemical and Ethnobotanical Databases. Compound unification was done through PubChem. Way2Drug PASS Online was used to analyse biological activities related to antidiabetic. SEA and Swiss Target Prediction databases to determine the target protein. Molecular docking was performed using Pyrx application and visualized with Biovia Discovery Studio. A total of 8 spoon leaf bioactive compounds targets alpha glucosidase, alpha amylase, and GLP-1 proteins that regulate the occurrence of diabetes with a Pa>0.5 value. Based on the docking results luteolin, plantagoside, nepetin and scutellarin are alpha glucosidase inhibitors with binding affinity values of -7.5, -8.7, -8.2 and -8.3 kcal/mol. Catalpol and neochlorgenic acid are alpha amylase inhibitors with binding affinity of -7.1 and -7, 3 kcal/mol. Aucubin and fumaric acid are GLP-1 acceptors with binding affinity values of -7.3 and -4.6 kcal/mol. Visualization of docking that nepetin and neochlorgenic acid compounds, have similar interactions and amino acid residues with control drugs so that they can be used as antidiabetic drug candidates.

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  • State University of Semarang
  • Universitas Indraprasta PGRI
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Rekan penulisOrganisasiArtikel bersama
Ari YuniastutiState University of Semarang7
Retno Sri IswariState University of Semarang5
Wulan ChristijantiAfiliasi tidak diketahui3
Aditya MariantiAfiliasi tidak diketahui3
Siti Harnina BintariAfiliasi tidak diketahui3
Nugrahaningsih WHAfiliasi tidak diketahui2
Wiwi IsnaeniState University of Semarang2
Priyantini WidiyaningrumAfiliasi tidak diketahui2
Ani RusilowatiState University of Semarang2
Didik Huswo UtomoAfiliasi tidak diketahui2
Enni Suwarsi RahayuState University of Semarang2
Lili Astuti IsnaeniAfiliasi tidak diketahui2
Yanuarita TursinawatiAfiliasi tidak diketahui1
Prima Gita IslamiAfiliasi tidak diketahui1
Kartika WidiyaningrumAfiliasi tidak diketahui1
Prima Gita Islami IslamiAfiliasi tidak diketahui1
Eva Ulfiatus ShofiaAfiliasi tidak diketahui1
Anggun Try SetyaningsihAfiliasi tidak diketahui1
Bagus Hammam FalahAfiliasi tidak diketahui1
Nana Kariada MartutiAfiliasi tidak diketahui1
Retno PurwantiAfiliasi tidak diketahui1
- UmarudinAfiliasi tidak diketahui1
Rheza Alfy YuliantoAfiliasi tidak diketahui1
Yuliana AstrianaAfiliasi tidak diketahui1
Ning SetiatiAfiliasi tidak diketahui1
Muhammad Rofiq NezarAfiliasi tidak diketahui1
Margareta RahayuningsihAfiliasi tidak diketahui1
Denny Herbianto BahtiarAfiliasi tidak diketahui1
Fatchun NaimAfiliasi tidak diketahui1
Siti Rofiatus Sa’adahAfiliasi tidak diketahui1
Sri UtamiUniversitas Indraprasta PGRI1
Yenni Tyas Wulandari K. EAfiliasi tidak diketahui1
Masrukan MasrukanState University of Semarang1
Heru SetyantoAfiliasi tidak diketahui1
Triastuti SulistyaningsihAfiliasi tidak diketahui1
Tri Sri NoorAsihAfiliasi tidak diketahui1
Fitri Arum SasiAfiliasi tidak diketahui1
Khoerina SalwaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JM/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Studi In Silico Senyawa Bioaktif Daun Sendok (Plantago Major) Sebagai Antidibetes</dc:title>
	<dc:creator xml:lang="en">Susanti, R</dc:creator>
	<dc:creator xml:lang="en">Astuti , Dinar Diyah</dc:creator>
	<dc:subject xml:lang="en">Antidiabetic</dc:subject>
	<dc:subject xml:lang="en">in silico</dc:subject>
	<dc:subject xml:lang="en">Plantago major</dc:subject>
	<dc:subject xml:lang="en">bioactive compound </dc:subject>
	<dc:description xml:lang="en">Diabetes Mellitus is a disease caused by decreased pancreatic function to produce insulin or insensitivity of insulin receptors. This research aims to analyse the bioactive compounds in spoon leaves as antidiabetics and the mechanism of action in silico. Bioactive compounds were collected using Dr. Duke's Phytochemical and Ethnobotanical Databases. Compound unification was done through PubChem. Way2Drug PASS Online was used to analyse biological activities related to antidiabetic. SEA and Swiss Target Prediction databases to determine the target protein. Molecular docking was performed using Pyrx application and visualized with Biovia Discovery Studio. A total of 8 spoon leaf bioactive compounds targets alpha glucosidase, alpha amylase, and GLP-1 proteins that regulate the occurrence of diabetes with a Pa&amp;gt;0.5 value. Based on the docking results luteolin, plantagoside, nepetin and scutellarin are alpha glucosidase inhibitors with binding affinity values of -7.5, -8.7, -8.2 and -8.3 kcal/mol. Catalpol and neochlorgenic acid are alpha amylase inhibitors with binding affinity of -7.1 and -7, 3 kcal/mol. Aucubin and fumaric acid are GLP-1 acceptors with binding affinity values of -7.3 and -4.6 kcal/mol. Visualization of docking that nepetin and neochlorgenic acid compounds, have similar interactions and amino acid residues with control drugs so that they can be used as antidiabetic drug candidates.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2026-10-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JM/article/view/22000</dc:identifier>
	<dc:identifier>10.15294/jm.v49i1.22000</dc:identifier>
	<dc:source xml:lang="en">Indonesian Journal of Mathematics and Natural Sciences; Vol. 49 No. 1 (2026): Volume 49 Nomor 1 April 2026; 29-41</dc:source>
	<dc:source>2774-7832</dc:source>
	<dc:source>10.15294/jm.v49i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JM/article/view/22000/11663</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Indonesian Journal of Mathematics and Natural Sciences</dc:rights>
</oai_dc:dc>