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Sunscreen Activity Test on Iler Leaf Ethanol Extract Cream (Coleus Scutellarioides (L) Benth) In Vivo

Journal of Science and Technology Research for Pharmacy · Vol. 3 No. 2 (2025) · hlm. 28–37

DOI
10.15294/jstrp.v3i2.9665
ISSN
2776-0685
Terbit
2025-07-10
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Indonesia is one of the countries known as a tropical climate country with a high intensity of sun exposure. The sun's UV rays have health benefits. However, UV rays also have negative effects on skin health. Therefore, additional protection against solar UV rays is needed, namely by using sunscreen preparations derived from Iler Leaves (Coleus scutellarioides (L) Benth) which contain flavonoid and phenolic compounds. The purpose of this study was to determine the most optimal ethanol extract cream formula of iler leaf (Coleus scutellarioides (L) Benth) after preparation evaluation and determine the sunscreen activity of iler leaf ethanol extract cream (Coleus scutellarioides (L) Benth) in vivo. This research is a real pure experiment or also called True Experimental Research and uses The post test Only Control Group Design method. The results obtained from the evaluation of the ethanol extract of iler leaf cream preparation formula are with a cream formula consisting of 1.5% iler leaf extract, 18% stearic acid, 2% TEA, 2% cetyl alcohol, 8% glycerin, 0.2% metal paraben, 0.02% propyl paraben and aquadest. And after in vivo testing on white rats, it was found that the ethanol extract cream preparation of iler leaves had sunscreen activity as evidenced by the erythema effect that appeared after exposure under sunlight. So it can be concluded that the most optimum cream formula is a formula containing 18% stearic acid and 2% TEA. And the iler leaf ethanol extract cream has sunscreen activity after in vivo testing.

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  • State University of Semarang
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AmeliyanaAfiliasi tidak diketahui1
Prisma Detty NuryanaAfiliasi tidak diketahui1
Nurul Fajar AgustinaAfiliasi tidak diketahui1
Erika WuryaningsihAfiliasi tidak diketahui1
Muhammad Shidqi Naufal AthallaAfiliasi tidak diketahui1
Ernessa Indah Rotua SIRAITAfiliasi tidak diketahui1
Rahma Annisa IzzaniaAfiliasi tidak diketahui1
Sigit PriatmokoState University of Semarang1
Senda Kartika RakainsaAfiliasi tidak diketahui1
Dhatu Sekar LarasatiAfiliasi tidak diketahui1
Neli Syahida Ni’maAfiliasi tidak diketahui1
Sitarina WidyariniAfiliasi tidak diketahui1
Nanang FakhrudinAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JSTRP/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Sunscreen Activity Test on Iler Leaf Ethanol Extract Cream (Coleus Scutellarioides (L) Benth) In Vivo</dc:title>
	<dc:creator xml:lang="en">Zalzabila Adelya Putri, Zalza</dc:creator>
	<dc:creator xml:lang="en">Widhihastuti, Endah </dc:creator>
	<dc:subject xml:lang="en">Sunscreen</dc:subject>
	<dc:subject xml:lang="en"> in vivo</dc:subject>
	<dc:subject xml:lang="en">Iler leaf</dc:subject>
	<dc:subject xml:lang="en">Coleus scutellarioides (L) Benth</dc:subject>
	<dc:description xml:lang="en">Indonesia is one of the countries known as a tropical climate country with a high intensity of sun exposure. The sun's UV rays have health benefits. However, UV rays also have negative effects on skin health. Therefore, additional protection against solar UV rays is needed, namely by using sunscreen preparations derived from Iler Leaves (Coleus scutellarioides (L) Benth) which contain flavonoid and phenolic compounds. The purpose of this study was to determine the most optimal ethanol extract cream formula of iler leaf (Coleus scutellarioides (L) Benth) after preparation evaluation and determine the sunscreen activity of iler leaf ethanol extract cream (Coleus scutellarioides (L) Benth) in vivo. This research is a real pure experiment or also called True Experimental Research and uses The post test Only Control Group Design method. The results obtained from the evaluation of the ethanol extract of iler leaf cream preparation formula are with a cream formula consisting of 1.5% iler leaf extract, 18% stearic acid, 2% TEA, 2% cetyl alcohol, 8% glycerin, 0.2% metal paraben, 0.02% propyl paraben and aquadest. And after in vivo testing on white rats, it was found that the ethanol extract cream preparation of iler leaves had sunscreen activity as evidenced by the erythema effect that appeared after exposure under sunlight. So it can be concluded that the most optimum cream formula is a formula containing 18% stearic acid and 2% TEA. And the iler leaf ethanol extract cream has sunscreen activity after in vivo testing.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-07-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JSTRP/article/view/9665</dc:identifier>
	<dc:identifier>10.15294/jstrp.v3i2.9665</dc:identifier>
	<dc:source xml:lang="en">Journal of Science and Technology Research for Pharmacy; Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy; 28-37</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JSTRP/article/view/9665/4335</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>