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Functional Food Development: Cassia fistula Stem Bark Ethanol Extract as a Potential Antioxidant and Anticancer Agent

Indonesian Food Science and Technology Journal · Vol. 9 No. 2 (2026) · hlm. 295–314

DOI
10.22437/ifstj.v9i2.53230
ISSN
2615-367X
Terbit
2026-07-31
Penerbit
Department of Technology of Agricultural product (THP) Jambi University
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

This study investigates the pharmacological potential of Cassia fistula (Tilai), a plant traditionally used by Indonesian tribes as both medicine and food. The ethnobotanical significance of this species has inspired scientific exploration of its bioactive compounds. The ethanol extract of Cassia fistula stem bark demonstrated strong antioxidant activity, with an IC50 of 7.512 μg/mL, comparable to Vitamin C's IC50 of 4.716 μg/mL, indicating effective free radical scavenging. Additionally, the extract exhibited notable cytotoxicity against MCF-7 breast cancer cells, with an IC50 of 51.26 μg/mL. UHPLC-HRMS analysis revealed nine bioactive compounds, mainly flavonoids, phenolics, and quinones, which may contribute to its biological activities. These findings support the hypothesis that Cassia fistula stem bark contains potent antioxidant and anticancer constituents, highlighting its potential as a natural source for developing therapeutic agents. This research provides valuable insights into the phytochemical profile of Cassia fistula and its cytotoxic effects, encouraging further studies to explore its mechanisms and applications in cancer treatment.

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  • Universitas Jambi
  • Padjadjaran University
  • National Research and Innovation Agency
  • Universitas Airlangga
  • University of Indonesia
  • IPB University
  • Sumatera Institute of Technology
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Rekan penulisOrganisasiArtikel bersama
Yusnaidar YusnaidarUniversitas Jambi9
Aghnia HazrinaPadjadjaran University5
Patihul HusniPadjadjaran University3
Madyawati LatiefUniversitas Jambi3
Eza Permata SariUniversitas Jambi2
Abu BakarUniversitas Airlangga2
Andita Fitri Mutiara RizkiNational Research and Innovation Agency2
Wihda Aisarul AzmiNational Research and Innovation Agency2
Melva LouisaUniversity of Indonesia2
I Made ArtikaIPB University2
Josephine Elizabeth SiregarNational Research and Innovation Agency2
Minarni MinarniUniversitas Jambi2
Margaret Dwi Wiwik ErnawatiUniversitas Jambi2
Asrial AsrialUniversitas Jambi2
Epinur EpinurUniversitas Jambi2
Syamsurizal SyamsurizalUniversitas Jambi1
I Putu MahendraSumatera Institute of Technology1
Diah Riski GustiUniversitas Jambi1
Intan LestariUniversitas Jambi1
Indra Lasmana TariganUniversitas Jambi1
M. DamrisUniversitas Jambi1
Ade AdriadiUniversitas Jambi1
Riki SaputraAfiliasi tidak diketahui1
Andy BrataAfiliasi tidak diketahui1
Eugenia GriseltaAfiliasi tidak diketahui1
Lismiati LismiatiAfiliasi tidak diketahui1
Erin AzkiantiAfiliasi tidak diketahui1
Uce LestariAfiliasi tidak diketahui1
Faizar FaridUniversitas Jambi1
Agus SyarifUniversitas Jambi1
Istiqomah MalindaUniversitas Jambi1
Nova SusantiUniversitas Jambi1
Mardian PeslinofUniversitas Jambi1
Restina BemisUniversitas Jambi1
Heriyanti HeriyantiUniversitas Jambi1

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/ifstj/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Functional Food Development: Cassia fistula Stem Bark Ethanol Extract as a Potential Antioxidant and Anticancer Agent</dc:title>
	<dc:creator xml:lang="en">Muhaimin, Muhaimin</dc:creator>
	<dc:creator xml:lang="en">Chaerunisaa, Anis Yohana</dc:creator>
	<dc:creator xml:lang="en">Lestari, Uce</dc:creator>
	<dc:creator xml:lang="en">Hirzan, Rifanza</dc:creator>
	<dc:creator xml:lang="en">Syahri, Wilda</dc:creator>
	<dc:subject xml:lang="en">Tilai (Cassia fistula)</dc:subject>
	<dc:subject xml:lang="en">breast cancer</dc:subject>
	<dc:subject xml:lang="en">phytochemicals</dc:subject>
	<dc:subject xml:lang="en">MCF-7 cells</dc:subject>
	<dc:description xml:lang="en">This study investigates the pharmacological potential of Cassia fistula (Tilai), a plant traditionally used by Indonesian tribes as both medicine and food. The ethnobotanical significance of this species has inspired scientific exploration of its bioactive compounds. The ethanol extract of Cassia fistula stem bark demonstrated strong antioxidant activity, with an IC50 of 7.512 μg/mL, comparable to Vitamin C's IC50 of 4.716 μg/mL, indicating effective free radical scavenging. Additionally, the extract exhibited notable cytotoxicity against MCF-7 breast cancer cells, with an IC50 of 51.26 μg/mL. UHPLC-HRMS analysis revealed nine bioactive compounds, mainly flavonoids, phenolics, and quinones, which may contribute to its biological activities. These findings support the hypothesis that Cassia fistula stem bark contains potent antioxidant and anticancer constituents, highlighting its potential as a natural source for developing therapeutic agents. This research provides valuable insights into the phytochemical profile of Cassia fistula and its cytotoxic effects, encouraging further studies to explore its mechanisms and applications in cancer treatment.</dc:description>
	<dc:publisher xml:lang="en">Department of Technology of Agricultural product (THP) Jambi University</dc:publisher>
	<dc:date>2026-07-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/ifstj/article/view/53230</dc:identifier>
	<dc:identifier>10.22437/ifstj.v9i2.53230</dc:identifier>
	<dc:source xml:lang="en">Indonesian Food Science and Technology Journal; Vol. 9 No. 2 (2026): Volume 9 Number 2, July 2026 |IFSTJ| ; 295-314</dc:source>
	<dc:source>2615-367X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/ifstj/article/view/53230/25268</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Indonesian Food Science and Technology Journal</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>