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A Cytotoxic Activity of Clitoria ternatea Flower Tea with the Cinnamon and Lemongrass Oil Vapor against T47D Breast Cancer Cells

Biosaintifika: Journal of Biology & Biology Education · Vol. 16 No. 3 (2024) · pp. 525–534

DOI
10.15294/biosaintifika.v16i3.8480
ISSN
2338-7610, 2085-191X
Published
2024-12-24
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Breast cancer is a deadly disease for women. It is crucial to take preventive measures, one of which involves using natural ingredients as chemopreventive agents. Clitoria ternatea flowers, cinnamon, and lemongrass oil have been proven to have cytotoxic activity in several studies. This research aims to analyze the effect of adding cinnamon and lemongrass oil vapor to C. ternatea flower tea on the cytotoxic activity of T47D breast cancer cells. Cytotoxic activity testing was carried out colorimetrically using the MTT (3- (4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) assay method. The results of the research showed that there was a decrease in the IC50 value of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor. The IC50 value of C. ternatea flower tea without additional ingredients was the most potent with 14159 μg/mL, compared to 15 g addition of cinnamon with 1164 μg/mL; meanwhile, for 15 seconds of evaporation time for lemongrass, it was at 331 μg/mL, respectively This research shows the potential of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor as a chemopreventive agent against breast cancer cells.

Keywords

Collaboration network of the authors

40 authors · 153 co-authorship links · 13 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • State University of Semarang
  • Universitas Sains Al-Qur'an
  • Universiti Sains Islam Malaysia
  • Walisongo State Islamic University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Nanik WijayatiState University of Semarang6
Lisdiana LisdianaAffiliation unknown4
Eko Budi SusatyoAffiliation unknown4
Kusoro SiadiAffiliation unknown4
Supartono SupartonoAffiliation unknown4
Endang SusilaningsihState University of Semarang4
Dyah Rini IndriyantiState University of Semarang4
Ari YuniastutiState University of Semarang3
LisdianaAffiliation unknown3
Woro SumarniState University of Semarang3
Sudarmin SudarminAffiliation unknown3
Sri MursitiAffiliation unknown3
Harjono HarjonoAffiliation unknown3
Indira RiastiwiAffiliation unknown2
R. SusantiAffiliation unknown2
Tjahyo SubrotoAffiliation unknown2
Ersanghono KusumoAffiliation unknown2
Bowo NurcahyoAffiliation unknown2
Murbangun NuswowatiState University of Semarang2
Sri HaryaniAffiliation unknown2
Priyantini WidiyaningrumAffiliation unknown2
Sri JuminiUniversitas Sains Al-Qur'an1
Sutikno MadnasriState University of Semarang1
Yatim Md NadrahUniversiti Sains Islam Malaysia1
H HamzahAffiliation unknown1
F FatiatunUniversitas Sains Al-Qur'an1
L. LastriState University of Semarang1
Apriliana DrastisiantiWalisongo State Islamic University1
E. KusumoState University of Semarang1
Trevor Graham OngomAffiliation unknown1
Etik Siswati NingrumAffiliation unknown1
Ratzinger LodoAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">A Cytotoxic Activity of Clitoria ternatea Flower Tea with the Cinnamon and Lemongrass Oil Vapor against T47D Breast Cancer Cells</dc:title>
	<dc:creator xml:lang="en">Cahyono, Edy</dc:creator>
	<dc:creator xml:lang="en">Handayani, Tri </dc:creator>
	<dc:creator xml:lang="en">WH, Nugrahaningsih </dc:creator>
	<dc:creator xml:lang="en">Azid, Saffanah Binti Mohd Ab </dc:creator>
	<dc:creator xml:lang="en">Alighiri, Dante </dc:creator>
	<dc:creator xml:lang="en">Zaky, Adrian Maulana </dc:creator>
	<dc:creator xml:lang="en">Aisyah, Sabila </dc:creator>
	<dc:creator xml:lang="en">Permatasari, Bella </dc:creator>
	<dc:subject xml:lang="en">C. ternatea; chemopreventive; cinnamon; flower tea; lemongrass oil; T47D cells</dc:subject>
	<dc:description xml:lang="en">Breast cancer is a deadly disease for women. It is crucial to take preventive measures, one of which involves using natural ingredients as chemopreventive agents. Clitoria ternatea flowers, cinnamon, and lemongrass oil have been proven to have cytotoxic activity in several studies. This research aims to analyze the effect of adding cinnamon and lemongrass oil vapor to C. ternatea flower tea on the cytotoxic activity of T47D breast cancer cells. Cytotoxic activity testing was carried out colorimetrically using the MTT (3- (4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) assay method. The results of the research showed that there was a decrease in the IC50 value of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor. The IC50 value of C. ternatea flower tea without additional ingredients was the most potent with 14159 μg/mL, compared to 15 g addition of cinnamon with 1164 μg/mL; meanwhile, for 15 seconds of evaporation time for lemongrass, it was at 331 μg/mL, respectively This research shows the potential of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor as a chemopreventive agent against breast cancer cells.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2024-12-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/8480</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v16i3.8480</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 16 No. 3 (2024): December 2024; 525-534</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v16i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/8480/2389</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>