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Chemical Profiles and Biological Activities of Microalga Chlorella sp. from Southeast Sulawesi

ILMU KELAUTAN: Indonesian Journal of Marine Sciences · Vol. 29 No. 2 (2024) · hlm. 233–240

DOI
10.14710/ik.ijms.29.2.233-240
ISSN
2406-7598, 0853-7291
Terbit
2024-06-20
Penerbit
Marine Science Department Diponegoro University
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Microalgae Chlorella sp. grows in the seas of South-East Sulawesi, Indonesia. However, information on the chemical and pharmaceutical aspects of this species from this region is still limited. Therefore, this research aims to explore the chemical contents and biological activities of Chlorella sp. The sample was collected from the Kali Biru and Nambo waters, Kendari. The microalgae were isolated by the agar plating technique and extracted by ethanol. Chemical content was analyzed by phytochemical screening, Liquid Chromatography-tandem Mass Spectroscopy (LC-MS/MS), Total Phenolics Content (TPC) and Total Flavonoids Contents (TFC). Biological activities evaluation includes antioxidant, toxicity, cytotoxicity and antimicrobial. Antioxidant potency was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals and ABTS (2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid). Toxicity and cytotoxicity properties were analyzed by BSLT (Brine Shrimp Lethality Test) and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays against Breast cancer (MCF-7) cell lines. Antimicrobial potency was tested towards E. coli, S. aureus and C. albicans. The result showed that ethanol extract of Chlorella sp. (EEC) contained phenolics, flavonoids, alkaloids and terpenoids/steroids which were supported by LC-MS/MS data, TPC and TFC with value 150.33 and 33.18 mgGAE.g-1 extract. Seven of ten identified major compounds caused this extract to have antioxidant and anticancer including xanthin, 1,1-Diethyl-3-oxo-2- triazanolate, Azelaic acid, ruspolinone, 6-keto prostaglandin F1a and glycol stearate. In general, the biological activity of EEC is less active than the positive controls for each assay. However, the EEC is more potential to be developed as antioxidant such as sunscreen and anticancer especially breast cancer with IC50 value 151-200 ppm and 100-500 ppm, respectively.

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  • Universitas Halu Oleo
  • Politeknik Bina Husada Kendari
  • National Research and Innovation Agency
  • National University of Malaysia
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Rekan penulisOrganisasiArtikel bersama
Suwarjoyowirayatno SuwarjoyowirayatnoUniversitas Halu Oleo18
Sahidin SahidinUniversitas Halu Oleo13
Ratna Diyah PalupiUniversitas Halu Oleo8
. RahmadaniAfiliasi tidak diketahui8
Muhammad Hajrul MalakaUniversitas Halu Oleo8
SRI REJEKIUniversitas Halu Oleo7
Nur AsyikUniversitas Halu Oleo7
Kobajashi Togo IsamuUniversitas Halu Oleo6
Dewi Nurhayati YusufUniversitas Halu Oleo6
Angriani FusvitaPoliteknik Bina Husada Kendari6
Nur Saadah DaudPoliteknik Bina Husada Kendari6
Andi KhaeruniUniversitas Halu Oleo5
Muhammad Ilyas YUniversitas Halu Oleo5
Tresjia Corina RakianUniversitas Halu Oleo4
Akhmad MansyurUniversitas Halu Oleo4
La Ode AfaUniversitas Halu Oleo3
La Ode SafuanUniversitas Halu Oleo3
Sitti LeomoUniversitas Halu Oleo3
La Ode HuliUniversitas Halu Oleo3
Muhidin MuhidinUniversitas Halu Oleo3
W WahyuniUniversitas Halu Oleo3
Roslindah Daeng SiangUniversitas Halu Oleo2
Nurdiana A.Afiliasi tidak diketahui2
Sri WangadiUniversitas Halu Oleo2
Andi BahrunUniversitas Halu Oleo2
La MudiUniversitas Halu Oleo2
Asriullah JabbarUniversitas Halu Oleo2
Rachmawati HasidUniversitas Halu Oleo2
Mohamad Nuh IbrahimUniversitas Halu Oleo2
Nini Mila RahniUniversitas Halu Oleo2
Marsuki IswandiUniversitas Halu Oleo2

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Sumber metadata: OAI-PMH (metadata jurnal) http://ejournal.undip.ac.id/index.php/ijms/oai, pertama di-harvest 8 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Chemical Profiles and Biological Activities of Microalga Chlorella sp. from Southeast Sulawesi</dc:title>
	<dc:creator>Haslianti, Haslianti</dc:creator>
	<dc:creator>Asnani, Asnani</dc:creator>
	<dc:creator>Fristiohady, Adryan</dc:creator>
	<dc:creator>Sadarun, Baru</dc:creator>
	<dc:creator>Sutariati, Gusti Ayu Kade</dc:creator>
	<dc:creator>Sundowo, Andini</dc:creator>
	<dc:creator>Yodha, Agung Wibawa Mahatva</dc:creator>
	<dc:creator>Baharum, Syarul Nataqain</dc:creator>
	<dc:creator>Idin, Sahidin</dc:creator>
	<dc:subject xml:lang="en-US">Chlorella sp.; Ethanol extract; Chemicals; Biological Activities; Southeast Sulawesi</dc:subject>
	<dc:description xml:lang="en-US">Microalgae Chlorella sp. grows in the seas of South-East Sulawesi, Indonesia. However, information on the chemical and pharmaceutical aspects of this species from this region is still limited. Therefore, this research aims to explore the chemical contents and biological activities of Chlorella sp. The sample was collected from the Kali Biru and Nambo waters, Kendari. The microalgae were isolated by the agar plating technique and extracted by ethanol. Chemical content was analyzed by phytochemical screening, Liquid Chromatography-tandem Mass Spectroscopy (LC-MS/MS), Total Phenolics Content (TPC) and Total Flavonoids Contents (TFC). Biological activities evaluation includes antioxidant, toxicity, cytotoxicity and antimicrobial. Antioxidant potency was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals and ABTS (2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid). Toxicity and cytotoxicity properties were analyzed by BSLT (Brine Shrimp Lethality Test) and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays against Breast cancer (MCF-7) cell lines. Antimicrobial potency was tested towards E. coli, S. aureus and C. albicans. The result showed that ethanol extract of Chlorella sp. (EEC) contained phenolics, flavonoids, alkaloids and terpenoids/steroids which were supported by LC-MS/MS data, TPC and TFC with value 150.33 and 33.18 mgGAE.g-1 extract. Seven of ten identified major compounds caused this extract to have antioxidant and anticancer including xanthin, 1,1-Diethyl-3-oxo-2- triazanolate, Azelaic acid, ruspolinone, 6-keto prostaglandin F1a and glycol stearate. In general, the biological activity of EEC is less active than the positive controls for each assay. However, the EEC is more potential to be developed as antioxidant such as sunscreen and anticancer especially breast cancer with IC50 value 151-200 ppm and 100-500 ppm, respectively.  </dc:description>
	<dc:publisher xml:lang="en-US">Marine Science Department Diponegoro University</dc:publisher>
	<dc:date>2024-06-20</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal.undip.ac.id/index.php/ijms/article/view/60828</dc:identifier>
	<dc:identifier>10.14710/ik.ijms.29.2.233-240</dc:identifier>
	<dc:source xml:lang="en-US">ILMU KELAUTAN: Indonesian Journal of Marine Sciences; Vol 29, No 2 (2024): Ilmu Kelautan; 233-240</dc:source>
	<dc:source>2406-7598</dc:source>
	<dc:source>0853-7291</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal.undip.ac.id/index.php/ijms/article/view/60828/pdf</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 ILMU KELAUTAN: Indonesian Journal of Marine Sciences</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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