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The Cytotoxic Activity of Marine Sponge-Derived Fungus Aspergillus nomius NC06 Against HT29 Colon Cancer Cells: Cytotoxic Activity of A. nomius NC06 Against HT29 Cancer Cells

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 14 No. 1 (2024) · hlm. 39–44

DOI
10.11594/jtls.14.01.05
ISSN
2527-4376, 2087-5517
Terbit
2024-01-25
Penerbit
Journal of Tropical Life Science
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

The study of natural products from marine-derived fungi has been interesting tense to researchers as drug discovery sources. Marine fungus from West Sumatera, Indonesia repeatedly showed their potential for cytotoxic and antimicrobial activities. This study aims to determine the cytotoxic activity against HT29 colon cancer cells of each fraction of ethyl acetate extracts from Aspergillus nomius NC06 derived from marine sponge Neopetrosia chaliniformis. A. nomius was cultivated with rice as a growth medium and extracted with ethyl acetate solvent and evaporated in vacuo to obtain ethyl acetate extract. Furthermore, the compounds of ethyl acetate extract were separated with the VLC (Vacuum Liquide Chromatography) method. Five fractions were obtained, which further investigated their cytotoxic activity against HT29 colon cancer cells by using an MTT assay. The result showed that fractions I and III were categorized as potential fractions due to their IC50 value of 13.12 ± 0.39 μg/mL and 2.59 ± 0.19 μg/mL, respectively. It was also supported by ANOVA to measure the effect of each concentration (0.1; 1; 10; 100 μg/mL) of each fraction on the viability percentage of HT29 cells with p < 0.005.

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  • Padjadjaran University
  • Hasanuddin University
  • Sekolah Tinggi Agama Islam Syubbanul Wathon Magelang
  • Universitas Halu Oleo
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Rekan penulisOrganisasiArtikel bersama
Inggita KusumastutyAfiliasi tidak diketahui8
Muhammad JufriAfiliasi tidak diketahui2
Ilyas ThahirAfiliasi tidak diketahui2
Fajar Ari NugrohoAfiliasi tidak diketahui2
M UtamaAfiliasi tidak diketahui2
Herwinarni HerwinarniAfiliasi tidak diketahui2
S RuslimAfiliasi tidak diketahui2
Sudarsono SudarsonoAfiliasi tidak diketahui2
Bambang SubaliAfiliasi tidak diketahui2
Muhamad SholikhunSekolah Tinggi Agama Islam Syubbanul Wathon Magelang1
Zulfatus SorayaAfiliasi tidak diketahui1
Milna WafirahSekolah Tinggi Agama Islam Syubbanul Wathon Magelang1
Budi AyuningsihPadjadjaran University1
Iman HernamanPadjadjaran University1
Tidi DhalikaPadjadjaran University1
Destu Putra RosmawanAfiliasi tidak diketahui1
Dedi RahmatPadjadjaran University1
Ansharullah AnsharullahUniversitas Halu Oleo1
Abdu Rahman BacoAfiliasi tidak diketahui1
Meki PranataAfiliasi tidak diketahui1
Rizqia Pramudita NugrahaAfiliasi tidak diketahui1
Nasrah SirajangHasanuddin University1
Salsabila Rahmadhani SHasanuddin University1
Ariesta Wibisono AndityaAfiliasi tidak diketahui1
Tandiyo RahayuAfiliasi tidak diketahui1
Fakhruddin FakhruddinAfiliasi tidak diketahui1
Wuryanto WuryantoAfiliasi tidak diketahui1
Supriyono SupriyonoAfiliasi tidak diketahui1
Diah PuspaAfiliasi tidak diketahui1
Surya GumilarAfiliasi tidak diketahui1
Eli TrisnowatiAfiliasi tidak diketahui1
Yusiran YusiranAfiliasi tidak diketahui1
Naili Rohmah IftitahAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The Cytotoxic Activity of Marine Sponge-Derived Fungus Aspergillus nomius NC06 Against HT29 Colon Cancer Cells: Cytotoxic Activity of A. nomius NC06 Against HT29 Cancer Cells</dc:title>
	<dc:creator xml:lang="en">Artasasta, Muh. Ade</dc:creator>
	<dc:creator xml:lang="en">Djamaan, Akmal</dc:creator>
	<dc:creator xml:lang="en">Yanwirasti, Yanwirasti</dc:creator>
	<dc:creator xml:lang="en">Taher, Muhammad</dc:creator>
	<dc:creator xml:lang="en">Djamaludin, Heder</dc:creator>
	<dc:creator xml:lang="en">Siswanto, Siswanto</dc:creator>
	<dc:creator xml:lang="en">Handayani, Dian</dc:creator>
	<dc:subject xml:lang="en">Aspergillus nomius</dc:subject>
	<dc:subject xml:lang="en">Cytotoxic activity</dc:subject>
	<dc:subject xml:lang="en"> HT29 colon cancer cell</dc:subject>
	<dc:description xml:lang="en">The study of natural products from marine-derived fungi has been interesting tense to researchers as drug discovery sources. Marine fungus from West Sumatera, Indonesia repeatedly showed their potential for cytotoxic and antimicrobial activities.  This study aims to determine the cytotoxic activity against HT29 colon cancer cells of each fraction of ethyl acetate extracts from Aspergillus nomius NC06 derived from marine sponge Neopetrosia chaliniformis. A. nomius was cultivated with rice as a growth medium and extracted with ethyl acetate solvent and evaporated in vacuo to obtain ethyl acetate extract. Furthermore, the compounds of ethyl acetate extract were separated with the VLC (Vacuum Liquide Chromatography) method. Five fractions were obtained, which further investigated their cytotoxic activity against HT29 colon cancer cells by using an MTT assay. The result showed that fractions I and III were categorized as potential fractions due to their IC50 value of 13.12 ± 0.39 μg/mL and 2.59 ± 0.19 μg/mL, respectively. It was also supported by ANOVA to measure the effect of each concentration (0.1; 1; 10; 100 μg/mL) of each fraction on the viability percentage of HT29 cells with p &amp;lt; 0.005.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2024-01-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/2823</dc:identifier>
	<dc:identifier>10.11594/jtls.14.01.05</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 14 No. 1 (2024); 39 – 44</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/2823/709</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Journal of Tropical Life Science</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>