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Uji Efek Antipiretik Ekstrak Etanol Buah Wualae (Etlingera elatior (Jack) R.M. Smith) Terhadap Mencit Jantan (Mus musculus L.) Galur Balb/C

Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan · Vol. 4 No. 1 (2018)

DOI
10.33772/pharmauho.v4i1.4622
ISSN
2715-4181
Published
2018-04-11
Publisher
Fakultas Farmasi Universitas Halu Oleo
Language
eng

Abstract

Wualae (Etlingera elatior (Jack) R.M. Smith) empirically been used by people to treat diseases and as food. This research was carried to determine the antipyretic activity of ethanol extracts of Wualae (Etlingera elatior (Jack) R.M. Smith) fruit on male mice (Mus musculus L) Balb/c along with ratio the effects of ethanol extracts of fruit Wualae with paracetamol as a antipyretic. Ethanol extracts of fruit Wualae obtained by maceration method using ethanol 96%. Male mice divided into 6 groups i.e: negative control (Na.CMC), positive control, and the treatment group (ethanol extracts of fruit Wualae 100 mg/KgBW, 200 mg/KgBW, 300 mg/KgBW, dan 400 mg/KgBW). Antipyretic activity tested by using DPT vaccine (Diphtheria Tetanus Pertussis) 0.1 cc intraperitoneally as an inducer and paracetamol 500 mg as a positive control. Temperature measurement determined for 3 hours with a 30 minutes interval. Data analysis was performed by Kruskal Wallis statistical analysis and continued with Mann-Whitney test. The results showed that the effects of ethanol extracts of wualae fruit at dose of 400 mg/KgBW has antipyretic effects with a total decrease of temperature was 1,237oC.Keywords: antipyretic, fever, Etlingera elatior, wualae, mice

Collaboration network of the authors

35 authors · 126 co-authorship links

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Sahidin SahidinAffiliation unknown7
Vica AspadiahAffiliation unknown4
Asrul SaniAffiliation unknown3
Rini HamsidiAffiliation unknown2
Fahria Nadiryati SadimantaraUniversitas Halu Oleo2
Gusti Ray SadimantaraAffiliation unknown2
Jumriani JumrianiAffiliation unknown2
Rahmat MuliadiAffiliation unknown2
Muhammad Israwan AzisAffiliation unknown2
Ruslin RuslinUniversitas Halu Oleo2
Dian MunasariAffiliation unknown2
Muzuni MuzuniAffiliation unknown2
Adryan FristiohadyAffiliation unknown2
Rina AndrianiAffiliation unknown2
Rizky Barkah RamadhaniAffiliation unknown2
Puspita SariAffiliation unknown2
Harleli HarleliUniversitas Halu Oleo1
Sartiah YusranAffiliation unknown1
Nur Illiyyin AkibAffiliation unknown1
Suryani SuryaniUniversitas Halu Oleo1
RAHMANPIU RAHMANPIUAffiliation unknown1
Dian AriastikaAffiliation unknown1
Henny KasmawatiUniversitas Halu Oleo1
Nur RahmayaniAffiliation unknown1
Asniah AsniahUniversitas Halu Oleo1
MUHAMMAD TAUFIKAffiliation unknown1
Parawansah ParawansahAffiliation unknown1
Zakiyatul MahmudahAffiliation unknown1
Muhammad Syukri SadimantaraUniversitas Halu Oleo1
SRI WAHYUNIAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/pharmauho/oai, first harvested 30 Okt 2026, last seen 30 Okt 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Uji Efek Antipiretik Ekstrak Etanol Buah Wualae (Etlingera elatior (Jack) R.M. Smith) Terhadap Mencit Jantan (Mus musculus L.) Galur Balb/C</dc:title>
	<dc:creator>Malik, Fadhliyah</dc:creator>
	<dc:creator>Ningsi, Andryani</dc:creator>
	<dc:creator>Bafadal, Mentarry</dc:creator>
	<dc:creator>Saktiani, Dwi Nur</dc:creator>
	<dc:creator>Wahyuni, Wahyuni</dc:creator>
	<dc:description xml:lang="en-US">Wualae (Etlingera elatior (Jack) R.M. Smith) empirically been used by people to treat diseases and as food. This research was carried to determine the antipyretic activity of ethanol extracts of Wualae (Etlingera elatior (Jack) R.M. Smith) fruit on male mice (Mus musculus L) Balb/c along with ratio the effects of ethanol extracts of fruit Wualae with paracetamol as a antipyretic. Ethanol extracts of fruit Wualae obtained by maceration method using ethanol 96%. Male mice divided into 6 groups i.e: negative control (Na.CMC), positive control, and the treatment group (ethanol extracts of fruit Wualae 100 mg/KgBW, 200 mg/KgBW, 300 mg/KgBW, dan 400 mg/KgBW). Antipyretic activity tested by using DPT vaccine (Diphtheria Tetanus Pertussis) 0.1 cc intraperitoneally as an inducer and paracetamol 500 mg as a positive control. Temperature measurement determined for 3 hours with a 30 minutes interval. Data analysis was performed by Kruskal Wallis statistical analysis and continued with Mann-Whitney test. The results showed that the effects of ethanol extracts of wualae fruit at dose of 400 mg/KgBW has antipyretic effects with a total decrease of temperature was 1,237oC.Keywords: antipyretic, fever, Etlingera elatior, wualae, mice</dc:description>
	<dc:publisher xml:lang="en-US">Fakultas Farmasi Universitas Halu Oleo</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2018-04-11</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/pharmauho/article/view/4622</dc:identifier>
	<dc:identifier>10.33772/pharmauho.v4i1.4622</dc:identifier>
	<dc:source xml:lang="en-US">Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan; Vol 4, No 1 (2018): Pharmauho</dc:source>
	<dc:source>2715-4181</dc:source>
	<dc:source>10.33772/pharmauho.v4i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/pharmauho/article/view/4622/3496</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Pharmauho</dc:rights>
</oai_dc:dc>