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Journal

HUBUNGAN KUANTITATIF STRUKTUR AKTIVITAS ANTIOKSIDAN SENYAWA TURUNAN APIGENIN

Indonesian Journal of Chemical Science · Vol. 4 No. 3 (2015)

DOI
10.15294/ijcs.v4i3.8285
ISSN
2502-6844, 2252-6951
Published
2015-11-01
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Penelitian ini menggunakan kajian secara komputasi mengenai HKSA senyawa turunan Apigenin menggunakan deskriptor sterik, hidrofobik dan elektronik. Nilai deskriptor diperoleh berdasarkan perhitungan kimia komputasi menggunakan program Gaussian-09 dan MarvinBeans-15.1.26. Data deskriptor sterik, hidrofobik dan teoritik dibandingkan dengan data Log 1/IC50 yang diperoleh dari literatur data eksperimental. Data hasil perhitungan diolah menggunakan program IBM SPSS 21 menggunakan metode analisis regresi multilinear. Diperoleh persamaan HKSA: Log 1/IC50 = (-19,114) Konstanta + (-103,550) HOMO + (1,036) IPs + (-2,595) Log P + (0,443) Momen Dipole + (0,384) Indeks Harary + (3,689) Indeks Balaban +( -6,244) Indeks Randic + ( 0,160) MSA. n = 11; R = 0,999; R2 = 0,998; SE = 0,0725; PRESS = 0,010513 Berdasarkan persamaan HKSA, didapatkan prediksi senyawa yang berpotensi sebagai antioksidan, yaitu senyawa 3’,3 dimetoksi Apigenin dengan nilai Log 1/IC50prediksi sebesar 3.57691.

Collaboration network of the authors

40 authors · 164 co-authorship links · 4 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • State University of Semarang
  • Universiti Teknologi MARA
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Endang SusilaningsihState University of Semarang7
Agung Tri PrasetyaState University of Semarang6
Sri HaryaniAffiliation unknown4
Sudarmin SudarminAffiliation unknown3
Harjono HarjonoAffiliation unknown3
Kasmadi Imam SupardiState University of Semarang3
Sri Susilogati SumartiState University of Semarang3
Nanik WijayatiState University of Semarang2
Sri NurhayatiAffiliation unknown2
Nuni WidiartiAffiliation unknown2
Harjito HarjitoAffiliation unknown2
Cepi KurniawanState University of Semarang1
M. DhiyaulkhaqState University of Semarang1
D. NasekhahAffiliation unknown1
M. H. IsmailUniversiti Teknologi MARA1
Novi Ratna DewiState University of Semarang1
Mahfud SyahroniAffiliation unknown1
Siti Herlina DewiState University of Semarang1
Eko Budi SusatyaAffiliation unknown1
Norma EralitaAffiliation unknown1
Rr. S.E PujiastutiAffiliation unknown1
Yosephine Debbie DamayantiAffiliation unknown1
Willy Tirza EdenAffiliation unknown1
M. Kholid Baror AbadiAffiliation unknown1
Zalfa Dwirakhma SaharaniAffiliation unknown1
Istijabah MufsirohAffiliation unknown1
Siti KhotijahAffiliation unknown1
Soeprodjo M.SiAffiliation unknown1
utari yulianingsihAffiliation unknown1
Woro SumarniState University of Semarang1
Stella Dila AsmaraAffiliation unknown1
Yuli AtriyantiAffiliation unknown1
Uma Fadzilia ArifinAffiliation unknown1
Murbangun NuswowatiState University of Semarang1
Resa Ani LestariAffiliation unknown1
Hikmatun Nurul KhotimAffiliation unknown1
Anna Nashrullah NashrullahAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/ijcs/oai, first harvested 5 Nov 2026, last seen 8 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">HUBUNGAN  KUANTITATIF  STRUKTUR  AKTIVITAS ANTIOKSIDAN SENYAWA  TURUNAN APIGENIN</dc:title>
	<dc:creator>Perwira, Grandys</dc:creator>
	<dc:creator>Kasmui, Kasmui</dc:creator>
	<dc:creator>Hadisaputro, Subiyanto</dc:creator>
	<dc:description xml:lang="en-US">Penelitian ini menggunakan kajian secara komputasi mengenai HKSA senyawa turunan Apigenin menggunakan deskriptor sterik, hidrofobik dan elektronik. Nilai deskriptor diperoleh berdasarkan perhitungan kimia komputasi menggunakan program Gaussian-09 dan MarvinBeans-15.1.26. Data deskriptor sterik, hidrofobik dan teoritik dibandingkan dengan data Log 1/IC50 yang diperoleh dari literatur data eksperimental. Data hasil perhitungan diolah  menggunakan  program IBM SPSS 21 menggunakan metode analisis regresi multilinear. Diperoleh persamaan HKSA: Log 1/IC50 = (-19,114) Konstanta + (-103,550) HOMO + (1,036) IPs + (-2,595) Log P + (0,443) Momen Dipole + (0,384) Indeks Harary + (3,689) Indeks Balaban +( -6,244) Indeks Randic + ( 0,160) MSA. n = 11 ; R = 0,999 ; R2 = 0,998 ; SE = 0,0725 ; PRESS = 0,010513 Berdasarkan persamaan HKSA, didapatkan prediksi senyawa yang berpotensi sebagai antioksidan, yaitu senyawa 3’,3 dimetoksi Apigenin dengan nilai Log 1/IC50prediksi sebesar 3.57691.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2015-11-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/ijcs/article/view/8285</dc:identifier>
	<dc:identifier>10.15294/ijcs.v4i3.8285</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Chemical Science; Vol 4 No 3 (2015)</dc:source>
	<dc:source>2502-6844</dc:source>
	<dc:source>2252-6951</dc:source>
	<dc:source>10.15294/ijcs.v4i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/ijcs/article/view/8285/5602</dc:relation>
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