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Antioxidant Activity and Pancreatic Lipase Inhibition of Curcuma aeruginosa Roxb Rhizome Fractions

Jurnal Biodjati · Vol. 9 No. 2 (2024) · hlm. 228–243

DOI
10.15575/biodjati.v9i2.33900
ISSN
2541-4208, 2548-1606
Terbit
2024-11-30
Penerbit
UIN Sunan Gunung Djati Bandung
Bahasa
eng

Abstrak

Antiobesity with a lipase inhibitor mechanism will block the hydrolysis of triglycerides into fatty acids and glycerol, while antioxidant compounds are very useful in conditions of obesity to prevent excess damage from degenerative diseases. Curcuma aeruginosa Roxb extract has been proven to have the effect of inhibiting pancreatic lipase so further effects will be seen at the fraction level. The purpose of this research is to investigate the phytochemical components,antioxidant activity and pancreatic lipase inhibition of Curcuma aeruginosa Roxb fractions. Ethanolic extract of the Curcuma aeruginosa Roxb rhizome was separated using the solid-liquid chromatography with 3 different solvents (n-hexane, ethyl acetate, ethanol) to give n-hexane (HF), ethyl acetate (EAF), and ethanol (EF), and the insoluble (IF) fractions. Each fraction detected phenolics, flavonoids, alkaloids, tannins, saponins, triterpenoids/steroids. EF has the highest total flavonoid and phenolic content. Antioxidant activity of all fractions were measured using DPPH reduction, ABTS, and FRAP methods. The best antioxidant activity of all fractions using the DPPH method was EF with IC50 21.93 ± 3.39µg/mL, ABTS method was HF with IC50 24.56±1,03 µg/mL and FRAP method was IF with IC50 20.79±1,03 µg/mL. Totals of phenolics and flavonoids in EF strongly support the antioxidant activity of the DPPH method. The highest inhibition of pancreatic lipase was found in EAF at 35.16±0.24 % (100 µg/ml). There was significant difference between EAF and xenical (orlistat) (p

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  • Institut Teknologi Sepuluh Nopember
  • State University of Semarang
  • University of Indonesia
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Rudi HartonoAfiliasi tidak diketahui3
Zulfa SakhiyyaAfiliasi tidak diketahui2
Dwi Anggani Linggar BharatiAfiliasi tidak diketahui2
Salsa SafiraAfiliasi tidak diketahui1
Wahyu Puji LestariAfiliasi tidak diketahui1
Christina AstutiningsihAfiliasi tidak diketahui1
Wan Ismahanisa IsmailAfiliasi tidak diketahui1
Mohammad Imam SufiyantoAfiliasi tidak diketahui1
Faidliyah Nilna MinahAfiliasi tidak diketahui1
Sri FirmiatyAfiliasi tidak diketahui1
Fahrur RoziInstitut Teknologi Sepuluh Nopember1
Ali MasyharAfiliasi tidak diketahui1
Heru SaputraAfiliasi tidak diketahui1
Dolendra PaudelAfiliasi tidak diketahui1
SRI WAHYUNIAfiliasi tidak diketahui1
Hana Azmi Zakiyyah MustaqimahAfiliasi tidak diketahui1
Issy YuliasriAfiliasi tidak diketahui1
Gracendy Aluz Clarita BudionoAfiliasi tidak diketahui1
Syarifa ManullangAfiliasi tidak diketahui1
Nunung SusilowatiAfiliasi tidak diketahui1
Dwi Anggani Linggar BharatiAfiliasi tidak diketahui1
Wigati MartinaAfiliasi tidak diketahui1
Oktianti Dwi AryaniAfiliasi tidak diketahui1
Titik WijayantiAfiliasi tidak diketahui1
Silvia Nanda Putri EritoAfiliasi tidak diketahui1
Ainur Rosyidah Azmie PutryAfiliasi tidak diketahui1
Hendi PratamaAfiliasi tidak diketahui1
Ema Sri RahayuAfiliasi tidak diketahui1
Ananda Poetri LuthfiansyahAfiliasi tidak diketahui1
Akidatul YusmalindaAfiliasi tidak diketahui1
Siti MaftukahAfiliasi tidak diketahui1
Hari WibawantoState University of Semarang1
Muhammad KhumaediAfiliasi tidak diketahui1
Widya -Afiliasi tidak diketahui1
Agus WidodoUniversity of Indonesia1
Cahyo YuwonoAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.uinsgd.ac.id/index.php/biodjati/oai, pertama di-harvest 7 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Antioxidant Activity and Pancreatic Lipase Inhibition of Curcuma aeruginosa Roxb Rhizome Fractions</dc:title>
	<dc:creator>Suharsanti, Ririn</dc:creator>
	<dc:creator>Wahyuono, Subagus</dc:creator>
	<dc:creator>Yuniarti, Nunung</dc:creator>
	<dc:creator>Astuti, Puji</dc:creator>
	<dc:subject xml:lang="en-US">antioxidant</dc:subject>
	<dc:subject xml:lang="en-US">curcuma aeruginosa</dc:subject>
	<dc:subject xml:lang="en-US">fraction</dc:subject>
	<dc:subject xml:lang="en-US">pancreatic lipase inhibition</dc:subject>
	<dc:description xml:lang="en-US">Antiobesity with a lipase inhibitor mechanism will block the hydrolysis of triglycerides into fatty acids and glycerol, while antioxidant compounds are very useful in conditions of obesity to prevent excess damage from degenerative diseases. Curcuma aeruginosa Roxb extract has been proven to have the effect of inhibiting pancreatic lipase so further effects will be seen at the fraction level. The purpose of this research is to investigate the phytochemical components ,antioxidant activity and pancreatic lipase inhibition of Curcuma aeruginosa Roxb fractions. Ethanolic extract of the Curcuma aeruginosa Roxb rhizome was separated using the solid-liquid chromatography with 3 different solvents (n-hexane, ethyl acetate, ethanol) to give n-hexane (HF), ethyl acetate (EAF),  and ethanol (EF), and the insoluble (IF) fractions. Each fraction detected phenolics, flavonoids, alkaloids, tannins, saponins, triterpenoids/steroids. EF has the highest total flavonoid and phenolic content. Antioxidant activity of all fractions were measured using DPPH reduction, ABTS, and FRAP methods. The best antioxidant activity of all fractions using the DPPH method was EF with IC50 21.93 ± 3.39µg/mL, ABTS method was HF with IC50 24.56±1,03 µg/mL and FRAP method was IF with IC50 20.79±1,03 µg/mL. Totals of phenolics and flavonoids in EF strongly support the antioxidant activity of the DPPH method. The highest inhibition of pancreatic lipase was found in EAF at 35.16±0.24 % (100 µg/ml). There was significant difference between EAF and xenical (orlistat) (p</dc:description>
	<dc:publisher xml:lang="en-US">UIN Sunan Gunung Djati Bandung</dc:publisher>
	<dc:date>2024-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/33900</dc:identifier>
	<dc:identifier>10.15575/biodjati.v9i2.33900</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Biodjati; Vol. 9 No. 2 (2024): November; 228-243</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biodjati; Vol 9 No 2 (2024): November; 228-243</dc:source>
	<dc:source>2541-4208</dc:source>
	<dc:source>2548-1606</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinsgd.ac.id/index.php/biodjati/article/view/33900/11920</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Jurnal Biodjati</dc:rights>
</oai_dc:dc>